Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia
The physiological importance of and therapeutic interest in dehydroepiandrosterone (DHEA) has been predominantly in relation to its action as an inhibitor of the promotion and progression of several kinds of tumours, including those of breast, prostate, lung, colon, liver and skin tissues. The aim o...
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2002
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00220795_v174_n3_p447_Suarez http://hdl.handle.net/20.500.12110/paper_00220795_v174_n3_p447_Suarez |
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paper:paper_00220795_v174_n3_p447_Suarez2023-06-08T14:45:26Z Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia diethylstilbestrol estrogen growth hormone leptin prasterone prolactin somatomedin C animal experiment article blood sampling breast tumor cancer inhibition colon tumor controlled study drug implant female growth hormone blood level hormone action hyperplasia hyperprolactinemia hypophysis disease liver tumor lung tumor nonhuman priority journal prolactin blood level prostate tumor radioimmunoassay rat rat strain skin tumor weight reduction Animals Dehydroepiandrosterone Diethylstilbestrol Female Growth Hormone Hyperplasia Insulin-Like Growth Factor I Leptin Models, Animal Organ Size Pituitary Gland Prolactin Rats Rats, Sprague-Dawley The physiological importance of and therapeutic interest in dehydroepiandrosterone (DHEA) has been predominantly in relation to its action as an inhibitor of the promotion and progression of several kinds of tumours, including those of breast, prostate, lung, colon, liver and skin tissues. The aim of the present study was to determine the role of DHEA in diethylstilboestrol (DES)-induced pituitary hyperplasia. Female Sprague-Dawley rats were divided into four treatment groups: DES (implanted s.c. with a 20 mg DES pellet), DHEA (two 50 mg DHEA pellets), DHEA/DES (both DHEA and DES pellets), and controls (not implanted). Every week, all rats were weighed and cycled, and jugular blood samples were obtained. After 7 weeks, rats were killed. Hypophyses were removed and weighed, and serum prolactin, GH, IGF-I and leptin levels were assayed by RIA. DHEA cotreatment reduced pituitary enlargement by 39% in DES-treated rats. It also reduced the hyperprolactinaemia (280.4 ± 43.6 ng/ml for DHEA/DES vs 823.5 ± 127.1 ng/ml for DES) and partially reversed the loss of body weight induced by DES. DHEA treatment did not modify the effects of DES on serum GH, IGF-I and leptin levels. But DHEA per se also increased pituitary weight and induced hyperprolactinaemia, although to a lesser degree than DES. We conclude that DHEA administration has beneficial effects on oestrogen-induced pituitary hyperplasia and hyperprolactinaemia, but the fact that DHEA per se also induces diverse hormonal effects and a slight pituitary enlargement limits its use as a possible therapeutic drug. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00220795_v174_n3_p447_Suarez http://hdl.handle.net/20.500.12110/paper_00220795_v174_n3_p447_Suarez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
diethylstilbestrol estrogen growth hormone leptin prasterone prolactin somatomedin C animal experiment article blood sampling breast tumor cancer inhibition colon tumor controlled study drug implant female growth hormone blood level hormone action hyperplasia hyperprolactinemia hypophysis disease liver tumor lung tumor nonhuman priority journal prolactin blood level prostate tumor radioimmunoassay rat rat strain skin tumor weight reduction Animals Dehydroepiandrosterone Diethylstilbestrol Female Growth Hormone Hyperplasia Insulin-Like Growth Factor I Leptin Models, Animal Organ Size Pituitary Gland Prolactin Rats Rats, Sprague-Dawley |
| spellingShingle |
diethylstilbestrol estrogen growth hormone leptin prasterone prolactin somatomedin C animal experiment article blood sampling breast tumor cancer inhibition colon tumor controlled study drug implant female growth hormone blood level hormone action hyperplasia hyperprolactinemia hypophysis disease liver tumor lung tumor nonhuman priority journal prolactin blood level prostate tumor radioimmunoassay rat rat strain skin tumor weight reduction Animals Dehydroepiandrosterone Diethylstilbestrol Female Growth Hormone Hyperplasia Insulin-Like Growth Factor I Leptin Models, Animal Organ Size Pituitary Gland Prolactin Rats Rats, Sprague-Dawley Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia |
| topic_facet |
diethylstilbestrol estrogen growth hormone leptin prasterone prolactin somatomedin C animal experiment article blood sampling breast tumor cancer inhibition colon tumor controlled study drug implant female growth hormone blood level hormone action hyperplasia hyperprolactinemia hypophysis disease liver tumor lung tumor nonhuman priority journal prolactin blood level prostate tumor radioimmunoassay rat rat strain skin tumor weight reduction Animals Dehydroepiandrosterone Diethylstilbestrol Female Growth Hormone Hyperplasia Insulin-Like Growth Factor I Leptin Models, Animal Organ Size Pituitary Gland Prolactin Rats Rats, Sprague-Dawley |
| description |
The physiological importance of and therapeutic interest in dehydroepiandrosterone (DHEA) has been predominantly in relation to its action as an inhibitor of the promotion and progression of several kinds of tumours, including those of breast, prostate, lung, colon, liver and skin tissues. The aim of the present study was to determine the role of DHEA in diethylstilboestrol (DES)-induced pituitary hyperplasia. Female Sprague-Dawley rats were divided into four treatment groups: DES (implanted s.c. with a 20 mg DES pellet), DHEA (two 50 mg DHEA pellets), DHEA/DES (both DHEA and DES pellets), and controls (not implanted). Every week, all rats were weighed and cycled, and jugular blood samples were obtained. After 7 weeks, rats were killed. Hypophyses were removed and weighed, and serum prolactin, GH, IGF-I and leptin levels were assayed by RIA. DHEA cotreatment reduced pituitary enlargement by 39% in DES-treated rats. It also reduced the hyperprolactinaemia (280.4 ± 43.6 ng/ml for DHEA/DES vs 823.5 ± 127.1 ng/ml for DES) and partially reversed the loss of body weight induced by DES. DHEA treatment did not modify the effects of DES on serum GH, IGF-I and leptin levels. But DHEA per se also increased pituitary weight and induced hyperprolactinaemia, although to a lesser degree than DES. We conclude that DHEA administration has beneficial effects on oestrogen-induced pituitary hyperplasia and hyperprolactinaemia, but the fact that DHEA per se also induces diverse hormonal effects and a slight pituitary enlargement limits its use as a possible therapeutic drug. |
| title |
Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia |
| title_short |
Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia |
| title_full |
Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia |
| title_fullStr |
Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia |
| title_full_unstemmed |
Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia |
| title_sort |
dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia |
| publishDate |
2002 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00220795_v174_n3_p447_Suarez http://hdl.handle.net/20.500.12110/paper_00220795_v174_n3_p447_Suarez |
| _version_ |
1768545632387072000 |