Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins

1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decr...

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Autores principales:	Batlle, Alcira María del Carmen, Afonso, Susana Graciela, Stella de Rosellini, Ana María Cristina
Publicado:	1986
Materias:	porphyrin uroporphyrinogen decarboxylase blood and hemopoietic system enzyme inactivation erythrocyte human human cell photoactivation Carboxy-Lyases Erythrocytes Humans Kinetics Photolysis Porphyrins Thermodynamics Ultraviolet Rays Uroporphyrinogen Decarboxylase
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v18_n2_p143_DelCBatlle http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0020711X_v18_n2_p143_DelCBatlle
record_format	dspace
spelling	paper:paper_0020711X_v18_n2_p143_DelCBatlle2023-06-08T14:41:07Z Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins Batlle, Alcira María del Carmen Afonso, Susana Graciela Stella de Rosellini, Ana María Cristina porphyrin uroporphyrinogen decarboxylase blood and hemopoietic system enzyme inactivation erythrocyte human human cell photoactivation Carboxy-Lyases Erythrocytes Humans Kinetics Photolysis Porphyrins Thermodynamics Ultraviolet Rays Uroporphyrinogen Decarboxylase 1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986. Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1986 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v18_n2_p143_DelCBatlle http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	porphyrin uroporphyrinogen decarboxylase blood and hemopoietic system enzyme inactivation erythrocyte human human cell photoactivation Carboxy-Lyases Erythrocytes Humans Kinetics Photolysis Porphyrins Thermodynamics Ultraviolet Rays Uroporphyrinogen Decarboxylase
spellingShingle	porphyrin uroporphyrinogen decarboxylase blood and hemopoietic system enzyme inactivation erythrocyte human human cell photoactivation Carboxy-Lyases Erythrocytes Humans Kinetics Photolysis Porphyrins Thermodynamics Ultraviolet Rays Uroporphyrinogen Decarboxylase Batlle, Alcira María del Carmen Afonso, Susana Graciela Stella de Rosellini, Ana María Cristina Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
topic_facet	porphyrin uroporphyrinogen decarboxylase blood and hemopoietic system enzyme inactivation erythrocyte human human cell photoactivation Carboxy-Lyases Erythrocytes Humans Kinetics Photolysis Porphyrins Thermodynamics Ultraviolet Rays Uroporphyrinogen Decarboxylase
description	1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986.
author	Batlle, Alcira María del Carmen Afonso, Susana Graciela Stella de Rosellini, Ana María Cristina
author_facet	Batlle, Alcira María del Carmen Afonso, Susana Graciela Stella de Rosellini, Ana María Cristina
author_sort	Batlle, Alcira María del Carmen
title	Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_short	Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_full	Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_fullStr	Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_full_unstemmed	Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_sort	photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
publishDate	1986
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v18_n2_p143_DelCBatlle http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle
work_keys_str_mv	AT batllealciramariadelcarmen photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins AT afonsosusanagraciela photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins AT stelladerosellinianamariacristina photodynamicinactivationofredcelluroporphyrinogendecarboxylasebyporphyrins
_version_	1768541970180866048

Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins

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