Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane
1. 1. Heptachlor and lindane are widespread chlorinated insecticides. But porphyrinogen carboxy-lyase seems to be a key enzyme in the porphyria produced by chlorinated compounds in mammals. It was then considered interesting to perform the present investigation, the purpose of which was to study: (a...
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1980
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v12_n5-6_p1033_Taira http://hdl.handle.net/20.500.12110/paper_0020711X_v12_n5-6_p1033_Taira |
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paper:paper_0020711X_v12_n5-6_p1033_Taira2023-06-08T14:41:01Z Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane Taira, María Cristina heptachlor lindane porphyrin Carboxy Lyases carboxylyase heptachlor lindane porphyrin porphyrinogen porphyrinogen carboxy lyase porphyrinogen carboxy-lyase proadifen animal experiment chicken embryo etiology hepatic porphyria human cell liver pollution porphyrinogen carboxylase preliminary communication animal article chick embryo drug effect enzymology metabolism Animal Carboxy-Lyases Chick Embryo Heptachlor Lindane Liver Porphyrinogens Porphyrins Proadifen Support, Non-U.S. Gov't 1. 1. Heptachlor and lindane are widespread chlorinated insecticides. But porphyrinogen carboxy-lyase seems to be a key enzyme in the porphyria produced by chlorinated compounds in mammals. It was then considered interesting to perform the present investigation, the purpose of which was to study: (a) the porphyrinogenic ability of heptachlor and lindane when they were administered in vivo to whole chick embryo and (b) the in vivo effect of heptachlor and lindane on porphyrinogen carboxy-lyase activity. 2. 2. The results obtained showed that both compounds produce a significant accumulation of hepatic porphyrins, that produced by lindane being greater than that produced by heptachlor. 3. 3. The effect of heptachlor and lindane administration on porphyrinogen carboxy-lyase was studied in embryos from New Hampshire and Leghorn strains and in New Hampshire 1-day old chicks. The influence of phenobarbital and SKF-525 A pretreatment on the response of porphyrinogen carboxy-lyase to these drugs was also studied in New Hampshire chick embryos. The results indicate that the drugs do not produce decreased enzyme activity in the New Hampshire embryos, while a decrease of enzyme activity in the White Leghorn embryos and in the New Hampshire new-born chicks was observed. Results from pretreatment assays suggest that the decrease of porphyrinogen carboxy-lyase activity seems to be associated with the formation of a drug metabolite. 4. 4. It is concluded that heptachlor and lindane are porphyrinogenic drugs and that the response of decarboxylating enzyme to them seems to be dependent on: (a) the strain, (b) the development of the animal and (c) the drug metabolization system; some of the lindane and heptachlor metabolites being responsible for hepatic porphyrinogen carboxy-lyase decrease. © 1980. Fil:Taira, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1980 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v12_n5-6_p1033_Taira http://hdl.handle.net/20.500.12110/paper_0020711X_v12_n5-6_p1033_Taira |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
heptachlor lindane porphyrin Carboxy Lyases carboxylyase heptachlor lindane porphyrin porphyrinogen porphyrinogen carboxy lyase porphyrinogen carboxy-lyase proadifen animal experiment chicken embryo etiology hepatic porphyria human cell liver pollution porphyrinogen carboxylase preliminary communication animal article chick embryo drug effect enzymology metabolism Animal Carboxy-Lyases Chick Embryo Heptachlor Lindane Liver Porphyrinogens Porphyrins Proadifen Support, Non-U.S. Gov't |
| spellingShingle |
heptachlor lindane porphyrin Carboxy Lyases carboxylyase heptachlor lindane porphyrin porphyrinogen porphyrinogen carboxy lyase porphyrinogen carboxy-lyase proadifen animal experiment chicken embryo etiology hepatic porphyria human cell liver pollution porphyrinogen carboxylase preliminary communication animal article chick embryo drug effect enzymology metabolism Animal Carboxy-Lyases Chick Embryo Heptachlor Lindane Liver Porphyrinogens Porphyrins Proadifen Support, Non-U.S. Gov't Taira, María Cristina Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane |
| topic_facet |
heptachlor lindane porphyrin Carboxy Lyases carboxylyase heptachlor lindane porphyrin porphyrinogen porphyrinogen carboxy lyase porphyrinogen carboxy-lyase proadifen animal experiment chicken embryo etiology hepatic porphyria human cell liver pollution porphyrinogen carboxylase preliminary communication animal article chick embryo drug effect enzymology metabolism Animal Carboxy-Lyases Chick Embryo Heptachlor Lindane Liver Porphyrinogens Porphyrins Proadifen Support, Non-U.S. Gov't |
| description |
1. 1. Heptachlor and lindane are widespread chlorinated insecticides. But porphyrinogen carboxy-lyase seems to be a key enzyme in the porphyria produced by chlorinated compounds in mammals. It was then considered interesting to perform the present investigation, the purpose of which was to study: (a) the porphyrinogenic ability of heptachlor and lindane when they were administered in vivo to whole chick embryo and (b) the in vivo effect of heptachlor and lindane on porphyrinogen carboxy-lyase activity. 2. 2. The results obtained showed that both compounds produce a significant accumulation of hepatic porphyrins, that produced by lindane being greater than that produced by heptachlor. 3. 3. The effect of heptachlor and lindane administration on porphyrinogen carboxy-lyase was studied in embryos from New Hampshire and Leghorn strains and in New Hampshire 1-day old chicks. The influence of phenobarbital and SKF-525 A pretreatment on the response of porphyrinogen carboxy-lyase to these drugs was also studied in New Hampshire chick embryos. The results indicate that the drugs do not produce decreased enzyme activity in the New Hampshire embryos, while a decrease of enzyme activity in the White Leghorn embryos and in the New Hampshire new-born chicks was observed. Results from pretreatment assays suggest that the decrease of porphyrinogen carboxy-lyase activity seems to be associated with the formation of a drug metabolite. 4. 4. It is concluded that heptachlor and lindane are porphyrinogenic drugs and that the response of decarboxylating enzyme to them seems to be dependent on: (a) the strain, (b) the development of the animal and (c) the drug metabolization system; some of the lindane and heptachlor metabolites being responsible for hepatic porphyrinogen carboxy-lyase decrease. © 1980. |
| author |
Taira, María Cristina |
| author_facet |
Taira, María Cristina |
| author_sort |
Taira, María Cristina |
| title |
Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane |
| title_short |
Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane |
| title_full |
Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane |
| title_fullStr |
Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane |
| title_full_unstemmed |
Porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane |
| title_sort |
porphyrinogen carboxy-lyase from chick embryo liver-in vivo effect of heptachlor and lindane |
| publishDate |
1980 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v12_n5-6_p1033_Taira http://hdl.handle.net/20.500.12110/paper_0020711X_v12_n5-6_p1033_Taira |
| work_keys_str_mv |
AT tairamariacristina porphyrinogencarboxylyasefromchickembryoliverinvivoeffectofheptachlorandlindane |
| _version_ |
1768542970706919424 |