The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections

Antibodies against the major cysteine proteinase (cruzipain) from Trypanosoma cruzi were detected in human sera obtained from patients with chronic Chagas' disease. Not only the intact 60-kDa enzyme but also its 25-kDa self-proteolysis fragment are antigenic in vivo. Although T. cruzi antigens...

Descripción completa

Guardado en:

Detalles Bibliográficos
Publicado:	1991
Materias:	antibody cysteine proteinase article chagas disease human tissue immunoblotting immunoreactivity nonhuman priority journal trypanosoma cruzi Animal Antibodies, Protozoan Antigens, Protozoan Blotting, Western Chagas Disease Cross Reactions Cysteine Endopeptidases Human Support, Non-U.S. Gov't Trypanosoma cruzi
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00199567_v59_n11_p4275_Martinez http://hdl.handle.net/20.500.12110/paper_00199567_v59_n11_p4275_Martinez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00199567_v59_n11_p4275_Martinez
record_format	dspace
spelling	paper:paper_00199567_v59_n11_p4275_Martinez2023-06-08T14:40:18Z The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections antibody cysteine proteinase article chagas disease human tissue immunoblotting immunoreactivity nonhuman priority journal trypanosoma cruzi Animal Antibodies, Protozoan Antigens, Protozoan Blotting, Western Chagas Disease Cross Reactions Cysteine Endopeptidases Human Support, Non-U.S. Gov't Trypanosoma cruzi Antibodies against the major cysteine proteinase (cruzipain) from Trypanosoma cruzi were detected in human sera obtained from patients with chronic Chagas' disease. Not only the intact 60-kDa enzyme but also its 25-kDa self-proteolysis fragment are antigenic in vivo. Although T. cruzi antigens 13 and 36 also reacted with the apparently monospecific antiproteinase serum, the antigenicity of cruzipain to human patients is genuine, since its reactivity was not modified by the adsorption of human sera with the recombinant proteins 13 and 36. 1991 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00199567_v59_n11_p4275_Martinez http://hdl.handle.net/20.500.12110/paper_00199567_v59_n11_p4275_Martinez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	antibody cysteine proteinase article chagas disease human tissue immunoblotting immunoreactivity nonhuman priority journal trypanosoma cruzi Animal Antibodies, Protozoan Antigens, Protozoan Blotting, Western Chagas Disease Cross Reactions Cysteine Endopeptidases Human Support, Non-U.S. Gov't Trypanosoma cruzi
spellingShingle	antibody cysteine proteinase article chagas disease human tissue immunoblotting immunoreactivity nonhuman priority journal trypanosoma cruzi Animal Antibodies, Protozoan Antigens, Protozoan Blotting, Western Chagas Disease Cross Reactions Cysteine Endopeptidases Human Support, Non-U.S. Gov't Trypanosoma cruzi The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections
topic_facet	antibody cysteine proteinase article chagas disease human tissue immunoblotting immunoreactivity nonhuman priority journal trypanosoma cruzi Animal Antibodies, Protozoan Antigens, Protozoan Blotting, Western Chagas Disease Cross Reactions Cysteine Endopeptidases Human Support, Non-U.S. Gov't Trypanosoma cruzi
description	Antibodies against the major cysteine proteinase (cruzipain) from Trypanosoma cruzi were detected in human sera obtained from patients with chronic Chagas' disease. Not only the intact 60-kDa enzyme but also its 25-kDa self-proteolysis fragment are antigenic in vivo. Although T. cruzi antigens 13 and 36 also reacted with the apparently monospecific antiproteinase serum, the antigenicity of cruzipain to human patients is genuine, since its reactivity was not modified by the adsorption of human sera with the recombinant proteins 13 and 36.
title	The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections
title_short	The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections
title_full	The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections
title_fullStr	The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections
title_full_unstemmed	The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections
title_sort	major cysteine proteinase (cruzipain) from trypanosoma cruzi is antigenic in human infections
publishDate	1991
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00199567_v59_n11_p4275_Martinez http://hdl.handle.net/20.500.12110/paper_00199567_v59_n11_p4275_Martinez
_version_	1768544670631067648

The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections

Ejemplares similares