Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice

Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ liga...

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Autores principales:	Elia, Evelin Mariel, Pustovrh, Maria Carolina, Amalfi, Sabrina, Motta, Alicia Beatriz
Publicado:	2011
Materias:	Lipoxygenases metformin peroxisome proliferator activated receptor gamma polycystic ovary syndrome uterus arachidonate 12 lipoxygenase animal experiment animal model animal tissue article controlled study enzyme synthesis female gene expression hyperandrogenism mouse nonhuman prepuberty priority journal protein expression rat signal transduction
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v95_n8_p2534_Elia http://hdl.handle.net/20.500.12110/paper_00150282_v95_n8_p2534_Elia
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00150282_v95_n8_p2534_Elia
record_format	dspace
spelling	paper:paper_00150282_v95_n8_p2534_Elia2023-06-08T14:37:58Z Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice Elia, Evelin Mariel Pustovrh, Maria Carolina Amalfi, Sabrina Motta, Alicia Beatriz Lipoxygenases metformin peroxisome proliferator activated receptor gamma polycystic ovary syndrome uterus arachidonate 12 lipoxygenase metformin peroxisome proliferator activated receptor gamma animal experiment animal model animal tissue article controlled study enzyme synthesis female gene expression hyperandrogenism mouse nonhuman prepuberty priority journal protein expression rat signal transduction uterus Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect. © 2011 by American Society for Reproductive Medicine. Fil:Elia, E.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pustovrh, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Amalfi, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Motta, A.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v95_n8_p2534_Elia http://hdl.handle.net/20.500.12110/paper_00150282_v95_n8_p2534_Elia
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Lipoxygenases metformin peroxisome proliferator activated receptor gamma polycystic ovary syndrome uterus arachidonate 12 lipoxygenase metformin peroxisome proliferator activated receptor gamma animal experiment animal model animal tissue article controlled study enzyme synthesis female gene expression hyperandrogenism mouse nonhuman prepuberty priority journal protein expression rat signal transduction uterus
spellingShingle	Lipoxygenases metformin peroxisome proliferator activated receptor gamma polycystic ovary syndrome uterus arachidonate 12 lipoxygenase metformin peroxisome proliferator activated receptor gamma animal experiment animal model animal tissue article controlled study enzyme synthesis female gene expression hyperandrogenism mouse nonhuman prepuberty priority journal protein expression rat signal transduction uterus Elia, Evelin Mariel Pustovrh, Maria Carolina Amalfi, Sabrina Motta, Alicia Beatriz Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
topic_facet	Lipoxygenases metformin peroxisome proliferator activated receptor gamma polycystic ovary syndrome uterus arachidonate 12 lipoxygenase metformin peroxisome proliferator activated receptor gamma animal experiment animal model animal tissue article controlled study enzyme synthesis female gene expression hyperandrogenism mouse nonhuman prepuberty priority journal protein expression rat signal transduction uterus
description	Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect. © 2011 by American Society for Reproductive Medicine.
author	Elia, Evelin Mariel Pustovrh, Maria Carolina Amalfi, Sabrina Motta, Alicia Beatriz
author_facet	Elia, Evelin Mariel Pustovrh, Maria Carolina Amalfi, Sabrina Motta, Alicia Beatriz
author_sort	Elia, Evelin Mariel
title	Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
title_short	Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
title_full	Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
title_fullStr	Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
title_full_unstemmed	Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
title_sort	link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
publishDate	2011
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v95_n8_p2534_Elia http://hdl.handle.net/20.500.12110/paper_00150282_v95_n8_p2534_Elia
work_keys_str_mv	AT eliaevelinmariel linkbetweenmetforminandtheperoxisomeproliferatoractivatedreceptorgpathwayintheuterinetissueofhyperandrogenizedprepubertalmice AT pustovrhmariacarolina linkbetweenmetforminandtheperoxisomeproliferatoractivatedreceptorgpathwayintheuterinetissueofhyperandrogenizedprepubertalmice AT amalfisabrina linkbetweenmetforminandtheperoxisomeproliferatoractivatedreceptorgpathwayintheuterinetissueofhyperandrogenizedprepubertalmice AT mottaaliciabeatriz linkbetweenmetforminandtheperoxisomeproliferatoractivatedreceptorgpathwayintheuterinetissueofhyperandrogenizedprepubertalmice
_version_	1768542627663183872

Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice

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