Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells

The GnRH agonist leuprolide acetate (LA) inhibited DNA synthesis in epidermal growth factor-stimulated human granulosa luteinized cell cultures. This effect was blocked by the prior addition of a GnRH antagonist antide (ANT), and this compound per se was able to produce a stimulatory effect of DNA s...

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Autores principales:	Vitale, Alejandra Mariel, Abramovich, Dalhia Nurit, Peluffo, Marina Cinthia, Tesone, Marta
Publicado:	2006
Materias:	iturelix leuprorelin apoptosis article cell proliferation DNA synthesis drug antagonism drug effect granulosa cell human human cell priority journal Apoptosis Cell Proliferation Female Gonadotropin-Releasing Hormone Granulosa Cells Humans Leuprolide Oligopeptides
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v85_n4_p1064_Vitale http://hdl.handle.net/20.500.12110/paper_00150282_v85_n4_p1064_Vitale
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00150282_v85_n4_p1064_Vitale
record_format	dspace
spelling	paper:paper_00150282_v85_n4_p1064_Vitale2023-06-08T14:37:56Z Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells Vitale, Alejandra Mariel Abramovich, Dalhia Nurit Peluffo, Marina Cinthia Tesone, Marta iturelix leuprorelin apoptosis article cell proliferation DNA synthesis drug antagonism drug effect granulosa cell human human cell priority journal Apoptosis Cell Proliferation Female Gonadotropin-Releasing Hormone Granulosa Cells Humans Leuprolide Oligopeptides The GnRH agonist leuprolide acetate (LA) inhibited DNA synthesis in epidermal growth factor-stimulated human granulosa luteinized cell cultures. This effect was blocked by the prior addition of a GnRH antagonist antide (ANT), and this compound per se was able to produce a stimulatory effect of DNA synthesis on basal conditions. Leuprolide acetate produced an increase in the percentage of apoptotic cells, and when these two factors were co-incubated, ANT blocked the apoptotic effect produced by LA. ©2006 by American Society for Reproductive Medicine. Fil:Vitale, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Abramovich, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Peluffo, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tesone, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v85_n4_p1064_Vitale http://hdl.handle.net/20.500.12110/paper_00150282_v85_n4_p1064_Vitale
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	iturelix leuprorelin apoptosis article cell proliferation DNA synthesis drug antagonism drug effect granulosa cell human human cell priority journal Apoptosis Cell Proliferation Female Gonadotropin-Releasing Hormone Granulosa Cells Humans Leuprolide Oligopeptides
spellingShingle	iturelix leuprorelin apoptosis article cell proliferation DNA synthesis drug antagonism drug effect granulosa cell human human cell priority journal Apoptosis Cell Proliferation Female Gonadotropin-Releasing Hormone Granulosa Cells Humans Leuprolide Oligopeptides Vitale, Alejandra Mariel Abramovich, Dalhia Nurit Peluffo, Marina Cinthia Tesone, Marta Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
topic_facet	iturelix leuprorelin apoptosis article cell proliferation DNA synthesis drug antagonism drug effect granulosa cell human human cell priority journal Apoptosis Cell Proliferation Female Gonadotropin-Releasing Hormone Granulosa Cells Humans Leuprolide Oligopeptides
description	The GnRH agonist leuprolide acetate (LA) inhibited DNA synthesis in epidermal growth factor-stimulated human granulosa luteinized cell cultures. This effect was blocked by the prior addition of a GnRH antagonist antide (ANT), and this compound per se was able to produce a stimulatory effect of DNA synthesis on basal conditions. Leuprolide acetate produced an increase in the percentage of apoptotic cells, and when these two factors were co-incubated, ANT blocked the apoptotic effect produced by LA. ©2006 by American Society for Reproductive Medicine.
author	Vitale, Alejandra Mariel Abramovich, Dalhia Nurit Peluffo, Marina Cinthia Tesone, Marta
author_facet	Vitale, Alejandra Mariel Abramovich, Dalhia Nurit Peluffo, Marina Cinthia Tesone, Marta
author_sort	Vitale, Alejandra Mariel
title	Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
title_short	Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
title_full	Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
title_fullStr	Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
title_full_unstemmed	Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
title_sort	effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells
publishDate	2006
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v85_n4_p1064_Vitale http://hdl.handle.net/20.500.12110/paper_00150282_v85_n4_p1064_Vitale
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Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells

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