Role of RSUME in inflammation and cancer
RSUME (for RWD-domain-containing sumoylation enhancer), RWDD3 gene, was identified from a pituitary tumor cell with increased tumorigenic and angiogenic potential, and has higher expression in cerebellum, pituitary, heart, kidney, liver, pancreas, adrenal gland and prostate. RSUME is induced by cell...
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paper:paper_00145793_v589_n22_p3330_AnticoArciuch2023-06-08T14:37:44Z Role of RSUME in inflammation and cancer Antico Arciuch, Valeria Gabriela Hypoxia RWD-domain-containing sumoylation enhancer RWDD3 Sumoylation VHL carrier proteins and binding proteins glucocorticoid glucocorticoid receptor hypoxia inducible factor 1 hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha I kappa B immunoglobulin enhancer binding protein protein Ubc9 RWD domain containing sumoylation enhancer protein SUMO protein thioester unclassified drug vasculotropin A von Hippel Lindau protein RSUME protein, human transcription factor acetylation amino terminal sequence breast cancer cancer growth carboxy terminal sequence carcinogenesis conjugation gene gene expression gene function glioma hemangioblastoma hemangioblastoma of the central nervous system homeostasis human hypophysis tumor hypoxia immune response inflammation kidney carcinoma malignant neoplastic disease pheochromocytoma of the adrenal gland phosphorylation prenylation priority journal protein degradation protein domain protein expression protein function protein processing protein protein interaction protein stability protein structure renal clear cell carcinoma Review RWDD3 gene signal transduction sumoylation transcription initiation transcription regulation ubiquitination VHL gene animal cell hypoxia inflammation metabolism neoplasm pathology Animals Cell Hypoxia Humans Inflammation Neoplasms Transcription Factors RSUME (for RWD-domain-containing sumoylation enhancer), RWDD3 gene, was identified from a pituitary tumor cell with increased tumorigenic and angiogenic potential, and has higher expression in cerebellum, pituitary, heart, kidney, liver, pancreas, adrenal gland and prostate. RSUME is induced by cellular stress like hypoxia and heat shock, and is increased in pituitary tumors, in gliomas and in VHL tumors. Seven splicing forms have been described. Two of them correspond to non-coding RNAs and the other five possess an RWD domain in the N-terminus and differ in their C-terminal end. RSUME enhances SUMO conjugation by interacting with the SUMO conjugase Ubc9, increases Ubc9 thioester formation and therefore favors sumoylation of specific targets. RSUME increases IκB levels and stabilizes HIF-1α during hypoxia, leading to inhibition of NF-κB and increased HIF-1 transcriptional activity. RSUME inhibits pVHL function, thus suppressing HIF-1 and 2α ubiquitination and degradation. Disruption of the RWD domain structure of RSUME indicated that this domain is critical for RSUME action. The findings point to an important role of RSUME in the regulation and stability of specific targets, which are key regulatory mediators in cancer and inflammation. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Fil:Antico Arciuch, V.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v589_n22_p3330_AnticoArciuch http://hdl.handle.net/20.500.12110/paper_00145793_v589_n22_p3330_AnticoArciuch |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Hypoxia RWD-domain-containing sumoylation enhancer RWDD3 Sumoylation VHL carrier proteins and binding proteins glucocorticoid glucocorticoid receptor hypoxia inducible factor 1 hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha I kappa B immunoglobulin enhancer binding protein protein Ubc9 RWD domain containing sumoylation enhancer protein SUMO protein thioester unclassified drug vasculotropin A von Hippel Lindau protein RSUME protein, human transcription factor acetylation amino terminal sequence breast cancer cancer growth carboxy terminal sequence carcinogenesis conjugation gene gene expression gene function glioma hemangioblastoma hemangioblastoma of the central nervous system homeostasis human hypophysis tumor hypoxia immune response inflammation kidney carcinoma malignant neoplastic disease pheochromocytoma of the adrenal gland phosphorylation prenylation priority journal protein degradation protein domain protein expression protein function protein processing protein protein interaction protein stability protein structure renal clear cell carcinoma Review RWDD3 gene signal transduction sumoylation transcription initiation transcription regulation ubiquitination VHL gene animal cell hypoxia inflammation metabolism neoplasm pathology Animals Cell Hypoxia Humans Inflammation Neoplasms Transcription Factors |
spellingShingle |
Hypoxia RWD-domain-containing sumoylation enhancer RWDD3 Sumoylation VHL carrier proteins and binding proteins glucocorticoid glucocorticoid receptor hypoxia inducible factor 1 hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha I kappa B immunoglobulin enhancer binding protein protein Ubc9 RWD domain containing sumoylation enhancer protein SUMO protein thioester unclassified drug vasculotropin A von Hippel Lindau protein RSUME protein, human transcription factor acetylation amino terminal sequence breast cancer cancer growth carboxy terminal sequence carcinogenesis conjugation gene gene expression gene function glioma hemangioblastoma hemangioblastoma of the central nervous system homeostasis human hypophysis tumor hypoxia immune response inflammation kidney carcinoma malignant neoplastic disease pheochromocytoma of the adrenal gland phosphorylation prenylation priority journal protein degradation protein domain protein expression protein function protein processing protein protein interaction protein stability protein structure renal clear cell carcinoma Review RWDD3 gene signal transduction sumoylation transcription initiation transcription regulation ubiquitination VHL gene animal cell hypoxia inflammation metabolism neoplasm pathology Animals Cell Hypoxia Humans Inflammation Neoplasms Transcription Factors Antico Arciuch, Valeria Gabriela Role of RSUME in inflammation and cancer |
topic_facet |
Hypoxia RWD-domain-containing sumoylation enhancer RWDD3 Sumoylation VHL carrier proteins and binding proteins glucocorticoid glucocorticoid receptor hypoxia inducible factor 1 hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha I kappa B immunoglobulin enhancer binding protein protein Ubc9 RWD domain containing sumoylation enhancer protein SUMO protein thioester unclassified drug vasculotropin A von Hippel Lindau protein RSUME protein, human transcription factor acetylation amino terminal sequence breast cancer cancer growth carboxy terminal sequence carcinogenesis conjugation gene gene expression gene function glioma hemangioblastoma hemangioblastoma of the central nervous system homeostasis human hypophysis tumor hypoxia immune response inflammation kidney carcinoma malignant neoplastic disease pheochromocytoma of the adrenal gland phosphorylation prenylation priority journal protein degradation protein domain protein expression protein function protein processing protein protein interaction protein stability protein structure renal clear cell carcinoma Review RWDD3 gene signal transduction sumoylation transcription initiation transcription regulation ubiquitination VHL gene animal cell hypoxia inflammation metabolism neoplasm pathology Animals Cell Hypoxia Humans Inflammation Neoplasms Transcription Factors |
description |
RSUME (for RWD-domain-containing sumoylation enhancer), RWDD3 gene, was identified from a pituitary tumor cell with increased tumorigenic and angiogenic potential, and has higher expression in cerebellum, pituitary, heart, kidney, liver, pancreas, adrenal gland and prostate. RSUME is induced by cellular stress like hypoxia and heat shock, and is increased in pituitary tumors, in gliomas and in VHL tumors. Seven splicing forms have been described. Two of them correspond to non-coding RNAs and the other five possess an RWD domain in the N-terminus and differ in their C-terminal end. RSUME enhances SUMO conjugation by interacting with the SUMO conjugase Ubc9, increases Ubc9 thioester formation and therefore favors sumoylation of specific targets. RSUME increases IκB levels and stabilizes HIF-1α during hypoxia, leading to inhibition of NF-κB and increased HIF-1 transcriptional activity. RSUME inhibits pVHL function, thus suppressing HIF-1 and 2α ubiquitination and degradation. Disruption of the RWD domain structure of RSUME indicated that this domain is critical for RSUME action. The findings point to an important role of RSUME in the regulation and stability of specific targets, which are key regulatory mediators in cancer and inflammation. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
author |
Antico Arciuch, Valeria Gabriela |
author_facet |
Antico Arciuch, Valeria Gabriela |
author_sort |
Antico Arciuch, Valeria Gabriela |
title |
Role of RSUME in inflammation and cancer |
title_short |
Role of RSUME in inflammation and cancer |
title_full |
Role of RSUME in inflammation and cancer |
title_fullStr |
Role of RSUME in inflammation and cancer |
title_full_unstemmed |
Role of RSUME in inflammation and cancer |
title_sort |
role of rsume in inflammation and cancer |
publishDate |
2015 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v589_n22_p3330_AnticoArciuch http://hdl.handle.net/20.500.12110/paper_00145793_v589_n22_p3330_AnticoArciuch |
work_keys_str_mv |
AT anticoarciuchvaleriagabriela roleofrsumeininflammationandcancer |
_version_ |
1768543017683124224 |