Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events
Transforming growth factor β1 (TGFβ1) had no mitogenic effect in Swiss 3T3 cells, but could increase prostaglandin F2α (PGF2α)-induced DNA synthesis. Insulin, but not prostaglandin E1 (PGE1), further enhanced PGF2α action at low TGFβ1 concentrations. TGFβ1 also acted concertedly with the protein kin...
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1994
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v356_n1_p21_deAlzaga http://hdl.handle.net/20.500.12110/paper_00145793_v356_n1_p21_deAlzaga |
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paper:paper_00145793_v356_n1_p21_deAlzaga2023-06-08T14:37:38Z Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events DNA synthesis Insulin Protein kinase C TGFβ1 glycerol 2 acetate 1 oleate insulin prostaglandin e1 prostaglandin f2 alpha protein kinase c transforming growth factor beta1 animal cell article controlled study dna synthesis mitogenesis mouse nonhuman priority journal signal transduction 3T3 Cells Alprostadil Animal Cell Division Dinoprost DNA Insulin Mice Mitogens Signal Transduction Support, Non-U.S. Gov't Transforming Growth Factor beta Transforming growth factor β1 (TGFβ1) had no mitogenic effect in Swiss 3T3 cells, but could increase prostaglandin F2α (PGF2α)-induced DNA synthesis. Insulin, but not prostaglandin E1 (PGE1), further enhanced PGF2α action at low TGFβ1 concentrations. TGFβ1 also acted concertedly with the protein kinase C (PKC) activator 1-oleoyl-2-acetylglycerol to induce mitogenesis. Thus, it appears that TGFβ1 and insulin act via separate signals, while TGFβ1 and PGE1 might share a common pathway not involving TGFβ1-mediated prostaglandin synthesis. These results suggest that TGFβ1 might elicit various signalling mechanisms to enhance PGF2α-triggered events. © 1994. 1994 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v356_n1_p21_deAlzaga http://hdl.handle.net/20.500.12110/paper_00145793_v356_n1_p21_deAlzaga |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
DNA synthesis Insulin Protein kinase C TGFβ1 glycerol 2 acetate 1 oleate insulin prostaglandin e1 prostaglandin f2 alpha protein kinase c transforming growth factor beta1 animal cell article controlled study dna synthesis mitogenesis mouse nonhuman priority journal signal transduction 3T3 Cells Alprostadil Animal Cell Division Dinoprost DNA Insulin Mice Mitogens Signal Transduction Support, Non-U.S. Gov't Transforming Growth Factor beta |
| spellingShingle |
DNA synthesis Insulin Protein kinase C TGFβ1 glycerol 2 acetate 1 oleate insulin prostaglandin e1 prostaglandin f2 alpha protein kinase c transforming growth factor beta1 animal cell article controlled study dna synthesis mitogenesis mouse nonhuman priority journal signal transduction 3T3 Cells Alprostadil Animal Cell Division Dinoprost DNA Insulin Mice Mitogens Signal Transduction Support, Non-U.S. Gov't Transforming Growth Factor beta Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events |
| topic_facet |
DNA synthesis Insulin Protein kinase C TGFβ1 glycerol 2 acetate 1 oleate insulin prostaglandin e1 prostaglandin f2 alpha protein kinase c transforming growth factor beta1 animal cell article controlled study dna synthesis mitogenesis mouse nonhuman priority journal signal transduction 3T3 Cells Alprostadil Animal Cell Division Dinoprost DNA Insulin Mice Mitogens Signal Transduction Support, Non-U.S. Gov't Transforming Growth Factor beta |
| description |
Transforming growth factor β1 (TGFβ1) had no mitogenic effect in Swiss 3T3 cells, but could increase prostaglandin F2α (PGF2α)-induced DNA synthesis. Insulin, but not prostaglandin E1 (PGE1), further enhanced PGF2α action at low TGFβ1 concentrations. TGFβ1 also acted concertedly with the protein kinase C (PKC) activator 1-oleoyl-2-acetylglycerol to induce mitogenesis. Thus, it appears that TGFβ1 and insulin act via separate signals, while TGFβ1 and PGE1 might share a common pathway not involving TGFβ1-mediated prostaglandin synthesis. These results suggest that TGFβ1 might elicit various signalling mechanisms to enhance PGF2α-triggered events. © 1994. |
| title |
Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events |
| title_short |
Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events |
| title_full |
Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events |
| title_fullStr |
Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events |
| title_full_unstemmed |
Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events |
| title_sort |
transforming growth factor β1, insulin and prostaglandin e1 enhance prostaglandin f2α mitogenic action in swiss 3t3 cells via separate events |
| publishDate |
1994 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v356_n1_p21_deAlzaga http://hdl.handle.net/20.500.12110/paper_00145793_v356_n1_p21_deAlzaga |
| _version_ |
1768542869401894912 |