The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter

The cAMP response element (CRE) and the CCAAT box of the fibronectin gene promoter are separated by only twenty base pairs. A specific factor that binds the CRE interacts cooperatively with the protein which binds to the adjacent CCAAT box, stimulating transcription [1992, J. Biol. Chem. 267, 12767-...

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Autores principales:	Srebrow, Anabella, Muro, Andrés Fernando, Kornblihtt, Alberto Rodolfo
Publicado:	1993
Materias:	ATF-2 CAAT box CRE Fibronectin gene promoter binding protein endogenous compound fibronectin article cyclic amp responsive element gene expression nonhuman priority journal promoter region rat transcription initiation Animal Base Sequence Blood Proteins DNA-Binding Protein, Cyclic AMP-Responsive Fibronectins Male Molecular Sequence Data Nuclear Proteins Promoter Regions (Genetics) Rats Rats, Sprague-Dawley Support, Non-U.S. Gov't Transcription Factors Transcription, Genetic
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v327_n1_p25_Srebrow http://hdl.handle.net/20.500.12110/paper_00145793_v327_n1_p25_Srebrow
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00145793_v327_n1_p25_Srebrow
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spelling	paper:paper_00145793_v327_n1_p25_Srebrow2023-06-08T14:37:37Z The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter Srebrow, Anabella Muro, Andrés Fernando Kornblihtt, Alberto Rodolfo ATF-2 CAAT box CRE Fibronectin gene promoter binding protein endogenous compound fibronectin article cyclic amp responsive element gene expression nonhuman priority journal promoter region rat transcription initiation Animal Base Sequence Blood Proteins DNA-Binding Protein, Cyclic AMP-Responsive Fibronectins Male Molecular Sequence Data Nuclear Proteins Promoter Regions (Genetics) Rats Rats, Sprague-Dawley Support, Non-U.S. Gov't Transcription Factors Transcription, Genetic The cAMP response element (CRE) and the CCAAT box of the fibronectin gene promoter are separated by only twenty base pairs. A specific factor that binds the CRE interacts cooperatively with the protein which binds to the adjacent CCAAT box, stimulating transcription [1992, J. Biol. Chem. 267, 12767-12774]. Here we show that the CRE factor is an heterodimer between a 43 kDa and the '73 kDa' CRE-binding proteins and we identify the latter as ATF-2 (also named CRE-BPI), a protein implicated in recruiting transcriptional activators to promoters, able to form heterodimers with Jun and for which a sequence-deduced MW of 55 kDa had been previously reported. © 1993. Fil:Srebrow, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Muro, A.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1993 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v327_n1_p25_Srebrow http://hdl.handle.net/20.500.12110/paper_00145793_v327_n1_p25_Srebrow
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	ATF-2 CAAT box CRE Fibronectin gene promoter binding protein endogenous compound fibronectin article cyclic amp responsive element gene expression nonhuman priority journal promoter region rat transcription initiation Animal Base Sequence Blood Proteins DNA-Binding Protein, Cyclic AMP-Responsive Fibronectins Male Molecular Sequence Data Nuclear Proteins Promoter Regions (Genetics) Rats Rats, Sprague-Dawley Support, Non-U.S. Gov't Transcription Factors Transcription, Genetic
spellingShingle	ATF-2 CAAT box CRE Fibronectin gene promoter binding protein endogenous compound fibronectin article cyclic amp responsive element gene expression nonhuman priority journal promoter region rat transcription initiation Animal Base Sequence Blood Proteins DNA-Binding Protein, Cyclic AMP-Responsive Fibronectins Male Molecular Sequence Data Nuclear Proteins Promoter Regions (Genetics) Rats Rats, Sprague-Dawley Support, Non-U.S. Gov't Transcription Factors Transcription, Genetic Srebrow, Anabella Muro, Andrés Fernando Kornblihtt, Alberto Rodolfo The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter
topic_facet	ATF-2 CAAT box CRE Fibronectin gene promoter binding protein endogenous compound fibronectin article cyclic amp responsive element gene expression nonhuman priority journal promoter region rat transcription initiation Animal Base Sequence Blood Proteins DNA-Binding Protein, Cyclic AMP-Responsive Fibronectins Male Molecular Sequence Data Nuclear Proteins Promoter Regions (Genetics) Rats Rats, Sprague-Dawley Support, Non-U.S. Gov't Transcription Factors Transcription, Genetic
description	The cAMP response element (CRE) and the CCAAT box of the fibronectin gene promoter are separated by only twenty base pairs. A specific factor that binds the CRE interacts cooperatively with the protein which binds to the adjacent CCAAT box, stimulating transcription [1992, J. Biol. Chem. 267, 12767-12774]. Here we show that the CRE factor is an heterodimer between a 43 kDa and the '73 kDa' CRE-binding proteins and we identify the latter as ATF-2 (also named CRE-BPI), a protein implicated in recruiting transcriptional activators to promoters, able to form heterodimers with Jun and for which a sequence-deduced MW of 55 kDa had been previously reported. © 1993.
author	Srebrow, Anabella Muro, Andrés Fernando Kornblihtt, Alberto Rodolfo
author_facet	Srebrow, Anabella Muro, Andrés Fernando Kornblihtt, Alberto Rodolfo
author_sort	Srebrow, Anabella
title	The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter
title_short	The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter
title_full	The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter
title_fullStr	The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter
title_full_unstemmed	The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter
title_sort	cre-binding factor atf-2 facilitates the occupation of the ccaat box in the fibronectin gene promoter
publishDate	1993
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v327_n1_p25_Srebrow http://hdl.handle.net/20.500.12110/paper_00145793_v327_n1_p25_Srebrow
work_keys_str_mv	AT srebrowanabella thecrebindingfactoratf2facilitatestheoccupationoftheccaatboxinthefibronectingenepromoter AT muroandresfernando thecrebindingfactoratf2facilitatestheoccupationoftheccaatboxinthefibronectingenepromoter AT kornblihttalbertorodolfo thecrebindingfactoratf2facilitatestheoccupationoftheccaatboxinthefibronectingenepromoter AT srebrowanabella crebindingfactoratf2facilitatestheoccupationoftheccaatboxinthefibronectingenepromoter AT muroandresfernando crebindingfactoratf2facilitatestheoccupationoftheccaatboxinthefibronectingenepromoter AT kornblihttalbertorodolfo crebindingfactoratf2facilitatestheoccupationoftheccaatboxinthefibronectingenepromoter
_version_	1768545217348108288

The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter

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