An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice

Treatment of neonatal mice with an antiviral factor, (AVF), obtained from the leaves of Melia azederach L. protected them against lethal encephalitis caused by Tacaribe virus inoculation. The degree of protection obtained varied from 66% to 100% depending on the virus dose. Similarly, administration...

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Autores principales:	Andrei, Graciela Mónica, Lampuri, Jorge Salvador, Coto, Celia Esther
Publicado:	1986
Materias:	Antiviral activity arenavirus Melia azedarach L Tacaribe virus viral encephalitis antivirus agent central nervous system experimental infection higher plant mouse nonhuman priority journal tacaribe arenavirus therapy virus encephalitis Animal Animals, Newborn Antiviral Agents Arenaviruses, New World Encephalitis Female Hemorrhagic Fever, American Lactation Mice Plant Extracts Pregnancy Support, Non-U.S. Gov't Virus Replication
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v42_n7_p843_Andrei http://hdl.handle.net/20.500.12110/paper_00144754_v42_n7_p843_Andrei
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00144754_v42_n7_p843_Andrei
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spelling	paper:paper_00144754_v42_n7_p843_Andrei2023-06-08T14:37:12Z An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice Andrei, Graciela Mónica Lampuri, Jorge Salvador Coto, Celia Esther Antiviral activity arenavirus Melia azedarach L Tacaribe virus viral encephalitis antivirus agent central nervous system experimental infection higher plant mouse nonhuman priority journal tacaribe arenavirus therapy virus encephalitis Animal Animals, Newborn Antiviral Agents Arenaviruses, New World Encephalitis Female Hemorrhagic Fever, American Lactation Mice Plant Extracts Pregnancy Support, Non-U.S. Gov't Virus Replication Treatment of neonatal mice with an antiviral factor, (AVF), obtained from the leaves of Melia azederach L. protected them against lethal encephalitis caused by Tacaribe virus inoculation. The degree of protection obtained varied from 66% to 100% depending on the virus dose. Similarly, administration of AVF to nursing mothers protected their offspring from developing virus encephalitis. AVF does not directly inactivate Tacaribe virus; it inhibits an early step (s) in the replication process in cell cultures. © 1986 Birkhäuser Verlag Basel. Fil:Andrei, G.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lampuri, J.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Coto, C.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1986 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v42_n7_p843_Andrei http://hdl.handle.net/20.500.12110/paper_00144754_v42_n7_p843_Andrei
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antiviral activity arenavirus Melia azedarach L Tacaribe virus viral encephalitis antivirus agent central nervous system experimental infection higher plant mouse nonhuman priority journal tacaribe arenavirus therapy virus encephalitis Animal Animals, Newborn Antiviral Agents Arenaviruses, New World Encephalitis Female Hemorrhagic Fever, American Lactation Mice Plant Extracts Pregnancy Support, Non-U.S. Gov't Virus Replication
spellingShingle	Antiviral activity arenavirus Melia azedarach L Tacaribe virus viral encephalitis antivirus agent central nervous system experimental infection higher plant mouse nonhuman priority journal tacaribe arenavirus therapy virus encephalitis Animal Animals, Newborn Antiviral Agents Arenaviruses, New World Encephalitis Female Hemorrhagic Fever, American Lactation Mice Plant Extracts Pregnancy Support, Non-U.S. Gov't Virus Replication Andrei, Graciela Mónica Lampuri, Jorge Salvador Coto, Celia Esther An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice
topic_facet	Antiviral activity arenavirus Melia azedarach L Tacaribe virus viral encephalitis antivirus agent central nervous system experimental infection higher plant mouse nonhuman priority journal tacaribe arenavirus therapy virus encephalitis Animal Animals, Newborn Antiviral Agents Arenaviruses, New World Encephalitis Female Hemorrhagic Fever, American Lactation Mice Plant Extracts Pregnancy Support, Non-U.S. Gov't Virus Replication
description	Treatment of neonatal mice with an antiviral factor, (AVF), obtained from the leaves of Melia azederach L. protected them against lethal encephalitis caused by Tacaribe virus inoculation. The degree of protection obtained varied from 66% to 100% depending on the virus dose. Similarly, administration of AVF to nursing mothers protected their offspring from developing virus encephalitis. AVF does not directly inactivate Tacaribe virus; it inhibits an early step (s) in the replication process in cell cultures. © 1986 Birkhäuser Verlag Basel.
author	Andrei, Graciela Mónica Lampuri, Jorge Salvador Coto, Celia Esther
author_facet	Andrei, Graciela Mónica Lampuri, Jorge Salvador Coto, Celia Esther
author_sort	Andrei, Graciela Mónica
title	An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice
title_short	An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice
title_full	An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice
title_fullStr	An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice
title_full_unstemmed	An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice
title_sort	antiviral factor from melia azedarach l. prevents tacaribe virus encephalitis in mice
publishDate	1986
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v42_n7_p843_Andrei http://hdl.handle.net/20.500.12110/paper_00144754_v42_n7_p843_Andrei
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An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice

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