A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures

Physiological amounts of estradiol (1 nM) significantly increased serotonin, conversion to melatonin and 5-methoxytryptophol by rat pineal glands in organ culture whereas larger, pharmacological, doses (i.e. 1000 nM) impaired it significantly. The stimulatory but not the inhibitory effect of estradi...

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Publicado:	1981
Materias:	5 methoxytryptophol estradiol melatonin puromycin radioisotope serotonin animal experiment drug metabolism endocrine system in vitro study organ culture pineal body rat Animal Dose-Response Relationship, Drug Estradiol Organ Culture Pineal Gland Puromycin Rats Serotonin Support, Non-U.S. Gov't
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v37_n2_p203_Cardinali http://hdl.handle.net/20.500.12110/paper_00144754_v37_n2_p203_Cardinali
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00144754_v37_n2_p203_Cardinali
record_format	dspace
spelling	paper:paper_00144754_v37_n2_p203_Cardinali2023-06-08T14:37:07Z A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures 5 methoxytryptophol estradiol melatonin puromycin radioisotope serotonin animal experiment drug metabolism endocrine system in vitro study organ culture pineal body rat Animal Dose-Response Relationship, Drug Estradiol Organ Culture Pineal Gland Puromycin Rats Serotonin Support, Non-U.S. Gov't Physiological amounts of estradiol (1 nM) significantly increased serotonin, conversion to melatonin and 5-methoxytryptophol by rat pineal glands in organ culture whereas larger, pharmacological, doses (i.e. 1000 nM) impaired it significantly. The stimulatory but not the inhibitory effect of estradiol was blocked by the simultaneous addition of puromycin in the culture medium. © 1981 Birkhäuser Verlag. 1981 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v37_n2_p203_Cardinali http://hdl.handle.net/20.500.12110/paper_00144754_v37_n2_p203_Cardinali
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	5 methoxytryptophol estradiol melatonin puromycin radioisotope serotonin animal experiment drug metabolism endocrine system in vitro study organ culture pineal body rat Animal Dose-Response Relationship, Drug Estradiol Organ Culture Pineal Gland Puromycin Rats Serotonin Support, Non-U.S. Gov't
spellingShingle	5 methoxytryptophol estradiol melatonin puromycin radioisotope serotonin animal experiment drug metabolism endocrine system in vitro study organ culture pineal body rat Animal Dose-Response Relationship, Drug Estradiol Organ Culture Pineal Gland Puromycin Rats Serotonin Support, Non-U.S. Gov't A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
topic_facet	5 methoxytryptophol estradiol melatonin puromycin radioisotope serotonin animal experiment drug metabolism endocrine system in vitro study organ culture pineal body rat Animal Dose-Response Relationship, Drug Estradiol Organ Culture Pineal Gland Puromycin Rats Serotonin Support, Non-U.S. Gov't
description	Physiological amounts of estradiol (1 nM) significantly increased serotonin, conversion to melatonin and 5-methoxytryptophol by rat pineal glands in organ culture whereas larger, pharmacological, doses (i.e. 1000 nM) impaired it significantly. The stimulatory but not the inhibitory effect of estradiol was blocked by the simultaneous addition of puromycin in the culture medium. © 1981 Birkhäuser Verlag.
title	A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
title_short	A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
title_full	A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
title_fullStr	A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
title_full_unstemmed	A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
title_sort	biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures
publishDate	1981
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144754_v37_n2_p203_Cardinali http://hdl.handle.net/20.500.12110/paper_00144754_v37_n2_p203_Cardinali
_version_	1768543067858534400

A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures

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