Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat
The effect of baclofen, β-(4-chlorophenyl)GABA, on prolactin secretion was investigated in rats under several experimental conditions. In adult male rats subjected either to immobilization, ether, swimming or cold stress there was a rapid increase of serum prolactin levels; acute pretreatment with b...
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1986
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v120_n1_p81_Deramo http://hdl.handle.net/20.500.12110/paper_00142999_v120_n1_p81_Deramo |
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paper:paper_00142999_v120_n1_p81_Deramo2023-06-08T14:36:49Z Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat Baclofen Prolactin Stress baclofen animal experiment central nervous system drug efficacy endocrine system hypophysis intraperitoneal drug administration nonhuman priority journal prolactin release rat stress Animal Baclofen Bicuculline Cold Female Male Ovariectomy Prolactin Rats Rats, Inbred Strains Receptors, GABA-A Restraint, Physical Stress Support, Non-U.S. Gov't Swimming The effect of baclofen, β-(4-chlorophenyl)GABA, on prolactin secretion was investigated in rats under several experimental conditions. In adult male rats subjected either to immobilization, ether, swimming or cold stress there was a rapid increase of serum prolactin levels; acute pretreatment with baclofen, 10 mg/kg i.p. inhibited the hormone response to all these stresses. The same blocking effect of the drug was observed in prepubertal male and female rats and in adult gonadectomized animals. In basal conditions, i.e. in undisturbed male rats, baclofen did not change the hormone titers significantly. Taken together our results indicate that baclofen blocks prolactin release when release of the hormone is dynamically stimulated by stress and this effect is relatively independent of the endocrine status of the rat. © 1986. 1986 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v120_n1_p81_Deramo http://hdl.handle.net/20.500.12110/paper_00142999_v120_n1_p81_Deramo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Baclofen Prolactin Stress baclofen animal experiment central nervous system drug efficacy endocrine system hypophysis intraperitoneal drug administration nonhuman priority journal prolactin release rat stress Animal Baclofen Bicuculline Cold Female Male Ovariectomy Prolactin Rats Rats, Inbred Strains Receptors, GABA-A Restraint, Physical Stress Support, Non-U.S. Gov't Swimming |
| spellingShingle |
Baclofen Prolactin Stress baclofen animal experiment central nervous system drug efficacy endocrine system hypophysis intraperitoneal drug administration nonhuman priority journal prolactin release rat stress Animal Baclofen Bicuculline Cold Female Male Ovariectomy Prolactin Rats Rats, Inbred Strains Receptors, GABA-A Restraint, Physical Stress Support, Non-U.S. Gov't Swimming Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat |
| topic_facet |
Baclofen Prolactin Stress baclofen animal experiment central nervous system drug efficacy endocrine system hypophysis intraperitoneal drug administration nonhuman priority journal prolactin release rat stress Animal Baclofen Bicuculline Cold Female Male Ovariectomy Prolactin Rats Rats, Inbred Strains Receptors, GABA-A Restraint, Physical Stress Support, Non-U.S. Gov't Swimming |
| description |
The effect of baclofen, β-(4-chlorophenyl)GABA, on prolactin secretion was investigated in rats under several experimental conditions. In adult male rats subjected either to immobilization, ether, swimming or cold stress there was a rapid increase of serum prolactin levels; acute pretreatment with baclofen, 10 mg/kg i.p. inhibited the hormone response to all these stresses. The same blocking effect of the drug was observed in prepubertal male and female rats and in adult gonadectomized animals. In basal conditions, i.e. in undisturbed male rats, baclofen did not change the hormone titers significantly. Taken together our results indicate that baclofen blocks prolactin release when release of the hormone is dynamically stimulated by stress and this effect is relatively independent of the endocrine status of the rat. © 1986. |
| title |
Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat |
| title_short |
Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat |
| title_full |
Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat |
| title_fullStr |
Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat |
| title_full_unstemmed |
Baclofen, a GABA derivative, inhibits stress-induced prolactin release in the rat |
| title_sort |
baclofen, a gaba derivative, inhibits stress-induced prolactin release in the rat |
| publishDate |
1986 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v120_n1_p81_Deramo http://hdl.handle.net/20.500.12110/paper_00142999_v120_n1_p81_Deramo |
| _version_ |
1768542581481799680 |