P-tyramine, a natural amine, inhibits prolactin release in vivo

p-Tyramine, an endogenous amine with sympathomimetic action, is found in the mammalian hypothalamus. When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or immobilization stress. The hyperprolactinemia achi...

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Publicado:	1985
Materias:	dopamine haloperidol metirosine tyramine animal experiment brain injury central nervous system drug efficacy endocrine system hypophysis male genital system median eminence nonhuman orchiectomy priority journal prolactin release rat stress alpha-Methyltyrosine Animal Castration Haloperidol Male Median Eminence Methyltyrosines Prolactin Rats Rats, Inbred Strains Stress Support, Non-U.S. Gov't Tyramine
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v116_n5_p2044_BecVillalobos http://hdl.handle.net/20.500.12110/paper_00137227_v116_n5_p2044_BecVillalobos
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00137227_v116_n5_p2044_BecVillalobos
record_format	dspace
spelling	paper:paper_00137227_v116_n5_p2044_BecVillalobos2023-06-08T14:36:04Z P-tyramine, a natural amine, inhibits prolactin release in vivo dopamine haloperidol metirosine tyramine animal experiment brain injury central nervous system drug efficacy endocrine system hypophysis male genital system median eminence nonhuman orchiectomy priority journal prolactin release rat stress alpha-Methyltyrosine Animal Castration Haloperidol Male Median Eminence Methyltyrosines Prolactin Rats Rats, Inbred Strains Stress Support, Non-U.S. Gov't Tyramine p-Tyramine, an endogenous amine with sympathomimetic action, is found in the mammalian hypothalamus. When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or immobilization stress. The hyperprolactinemia achieved by this last procedure was inhibited by both tyramine and dopamine; tyramine produced the same effect as dopamine at a dose 5 times greater. When PRL levels were increased by pretreatment with a-methyl-p-tyrosine or halperidol, once again both tyramine and dopamine lowered PRL titers. The hypoprolactinemic effect of p-tyramine was also observed in median eminence-lesioned animals, suggesting a pituitary site of action. These results show that low amounts of tyramine, a naturally occurring amine, can inhibit in vivo increases in PRL levels achieved physiologically or pharmacologically. © 1985 by The Endocrine Society. 1985 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v116_n5_p2044_BecVillalobos http://hdl.handle.net/20.500.12110/paper_00137227_v116_n5_p2044_BecVillalobos
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	dopamine haloperidol metirosine tyramine animal experiment brain injury central nervous system drug efficacy endocrine system hypophysis male genital system median eminence nonhuman orchiectomy priority journal prolactin release rat stress alpha-Methyltyrosine Animal Castration Haloperidol Male Median Eminence Methyltyrosines Prolactin Rats Rats, Inbred Strains Stress Support, Non-U.S. Gov't Tyramine
spellingShingle	dopamine haloperidol metirosine tyramine animal experiment brain injury central nervous system drug efficacy endocrine system hypophysis male genital system median eminence nonhuman orchiectomy priority journal prolactin release rat stress alpha-Methyltyrosine Animal Castration Haloperidol Male Median Eminence Methyltyrosines Prolactin Rats Rats, Inbred Strains Stress Support, Non-U.S. Gov't Tyramine P-tyramine, a natural amine, inhibits prolactin release in vivo
topic_facet	dopamine haloperidol metirosine tyramine animal experiment brain injury central nervous system drug efficacy endocrine system hypophysis male genital system median eminence nonhuman orchiectomy priority journal prolactin release rat stress alpha-Methyltyrosine Animal Castration Haloperidol Male Median Eminence Methyltyrosines Prolactin Rats Rats, Inbred Strains Stress Support, Non-U.S. Gov't Tyramine
description	p-Tyramine, an endogenous amine with sympathomimetic action, is found in the mammalian hypothalamus. When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or immobilization stress. The hyperprolactinemia achieved by this last procedure was inhibited by both tyramine and dopamine; tyramine produced the same effect as dopamine at a dose 5 times greater. When PRL levels were increased by pretreatment with a-methyl-p-tyrosine or halperidol, once again both tyramine and dopamine lowered PRL titers. The hypoprolactinemic effect of p-tyramine was also observed in median eminence-lesioned animals, suggesting a pituitary site of action. These results show that low amounts of tyramine, a naturally occurring amine, can inhibit in vivo increases in PRL levels achieved physiologically or pharmacologically. © 1985 by The Endocrine Society.
title	P-tyramine, a natural amine, inhibits prolactin release in vivo
title_short	P-tyramine, a natural amine, inhibits prolactin release in vivo
title_full	P-tyramine, a natural amine, inhibits prolactin release in vivo
title_fullStr	P-tyramine, a natural amine, inhibits prolactin release in vivo
title_full_unstemmed	P-tyramine, a natural amine, inhibits prolactin release in vivo
title_sort	p-tyramine, a natural amine, inhibits prolactin release in vivo
publishDate	1985
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v116_n5_p2044_BecVillalobos http://hdl.handle.net/20.500.12110/paper_00137227_v116_n5_p2044_BecVillalobos
_version_	1768542673522655232

P-tyramine, a natural amine, inhibits prolactin release in vivo

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