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spelling paper:paper_00137227_v109_n6_p2202_Pisarev2023-06-08T14:36:02Z Role of the sympathetic nervous system in the control of the goitrogenic response in the rat dihydroalprenolol h 3 dihydroergocryptine h 3 imidazole radioisotope rubidium 86 thiamazole thyrotropin unclassified drug uridine h 3 adrenergic system animal experiment article autonomic nervous system endocrine system goiter intraperitoneal drug administration pineal body pinealectomy rat superior cervical ganglionectomy thyroid gland Animals Dopamine Epinephrine Ganglia, Sympathetic Goiter Kinetics Male Norepinephrine Pineal Gland Rats Rats, Inbred Strains Receptors, Adrenergic, alpha Receptors, Adrenergic, beta Rubidium Thyroid Gland Thyrotropin Transcription, Genetic The role of the sympathetic nervous system in the control of the goitrogenic response was examined in adult male rats subjected to superior cervical ganglionectomy (SCGx) 7 days earlier. In the first experiment, superior cervical ganglionectomized (SCGx) or sham-operated animals were treated with the goitrogenic agent methylmercaptoimidazole (MMI) for 4 days, and their thyroid weights and plasma TSH levels were measured. After MMI administration, the increase in thyroid weight was significantly greater in SCGx than in sham-operated rats. The plasma TSH increases after MMI were similar in both groups. To rule out the possible involvement of the pineal gland, MMI treatment was carried out in rats subjected to pinealectomy or sham pinealectomy 7 days earlier. Thyroid weights and plasma TSH levels after pinealectomy were not different from controls in vehicle- or MMI-treated rats. In a third experiment, the goitrogenic response to TSH was assessed in SCGx or shamoperated rats; the thyroid weight of SCGx animals increased by 72% after TSH treatment compared to a 35% increase in the controls (P < 0.01). Seven days after SCGx [3H]uridine incorporation into thyroid RNA increased significantly by 64%, and 4 weeks after SCGx, spontaneous goiter developed. Blood flow, estimated from the uptake of a tracer dose of 86Rb, decreased significantly in the thyroid and pineal gland after SCGx. Norepinephrine and epinephrine levels in the thyroid gland were depressed 70-80% within 24 h after SCGx, whereas dopamine levels remained unaltered. An increase in the number of aadrenoceptor sites, assessed by [3H]dihydroergocryptine binding to thyroid membranes, was found in SCGx rats, while the β- adrenoceptors (assessed by [3H]dihydroalprenolol binding) did not change. The results suggest that the cervical Sympathetics normally exert a negative influence on thyroid function in the rat. (Endocrinology 109: 2202, 1981). © 1981 by The Endocrine Society. 1981 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v109_n6_p2202_Pisarev http://hdl.handle.net/20.500.12110/paper_00137227_v109_n6_p2202_Pisarev
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic dihydroalprenolol h 3
dihydroergocryptine h 3
imidazole
radioisotope
rubidium 86
thiamazole
thyrotropin
unclassified drug
uridine h 3
adrenergic system
animal experiment
article
autonomic nervous system
endocrine system
goiter
intraperitoneal drug administration
pineal body
pinealectomy
rat
superior cervical ganglionectomy
thyroid gland
Animals
Dopamine
Epinephrine
Ganglia, Sympathetic
Goiter
Kinetics
Male
Norepinephrine
Pineal Gland
Rats
Rats, Inbred Strains
Receptors, Adrenergic, alpha
Receptors, Adrenergic, beta
Rubidium
Thyroid Gland
Thyrotropin
Transcription, Genetic
spellingShingle dihydroalprenolol h 3
dihydroergocryptine h 3
imidazole
radioisotope
rubidium 86
thiamazole
thyrotropin
unclassified drug
uridine h 3
adrenergic system
animal experiment
article
autonomic nervous system
endocrine system
goiter
intraperitoneal drug administration
pineal body
pinealectomy
rat
superior cervical ganglionectomy
thyroid gland
Animals
Dopamine
Epinephrine
Ganglia, Sympathetic
Goiter
Kinetics
Male
Norepinephrine
Pineal Gland
Rats
Rats, Inbred Strains
Receptors, Adrenergic, alpha
Receptors, Adrenergic, beta
Rubidium
Thyroid Gland
Thyrotropin
Transcription, Genetic
Role of the sympathetic nervous system in the control of the goitrogenic response in the rat
topic_facet dihydroalprenolol h 3
dihydroergocryptine h 3
imidazole
radioisotope
rubidium 86
thiamazole
thyrotropin
unclassified drug
uridine h 3
adrenergic system
animal experiment
article
autonomic nervous system
endocrine system
goiter
intraperitoneal drug administration
pineal body
pinealectomy
rat
superior cervical ganglionectomy
thyroid gland
Animals
Dopamine
Epinephrine
Ganglia, Sympathetic
Goiter
Kinetics
Male
Norepinephrine
Pineal Gland
Rats
Rats, Inbred Strains
Receptors, Adrenergic, alpha
Receptors, Adrenergic, beta
Rubidium
Thyroid Gland
Thyrotropin
Transcription, Genetic
description The role of the sympathetic nervous system in the control of the goitrogenic response was examined in adult male rats subjected to superior cervical ganglionectomy (SCGx) 7 days earlier. In the first experiment, superior cervical ganglionectomized (SCGx) or sham-operated animals were treated with the goitrogenic agent methylmercaptoimidazole (MMI) for 4 days, and their thyroid weights and plasma TSH levels were measured. After MMI administration, the increase in thyroid weight was significantly greater in SCGx than in sham-operated rats. The plasma TSH increases after MMI were similar in both groups. To rule out the possible involvement of the pineal gland, MMI treatment was carried out in rats subjected to pinealectomy or sham pinealectomy 7 days earlier. Thyroid weights and plasma TSH levels after pinealectomy were not different from controls in vehicle- or MMI-treated rats. In a third experiment, the goitrogenic response to TSH was assessed in SCGx or shamoperated rats; the thyroid weight of SCGx animals increased by 72% after TSH treatment compared to a 35% increase in the controls (P < 0.01). Seven days after SCGx [3H]uridine incorporation into thyroid RNA increased significantly by 64%, and 4 weeks after SCGx, spontaneous goiter developed. Blood flow, estimated from the uptake of a tracer dose of 86Rb, decreased significantly in the thyroid and pineal gland after SCGx. Norepinephrine and epinephrine levels in the thyroid gland were depressed 70-80% within 24 h after SCGx, whereas dopamine levels remained unaltered. An increase in the number of aadrenoceptor sites, assessed by [3H]dihydroergocryptine binding to thyroid membranes, was found in SCGx rats, while the β- adrenoceptors (assessed by [3H]dihydroalprenolol binding) did not change. The results suggest that the cervical Sympathetics normally exert a negative influence on thyroid function in the rat. (Endocrinology 109: 2202, 1981). © 1981 by The Endocrine Society.
title Role of the sympathetic nervous system in the control of the goitrogenic response in the rat
title_short Role of the sympathetic nervous system in the control of the goitrogenic response in the rat
title_full Role of the sympathetic nervous system in the control of the goitrogenic response in the rat
title_fullStr Role of the sympathetic nervous system in the control of the goitrogenic response in the rat
title_full_unstemmed Role of the sympathetic nervous system in the control of the goitrogenic response in the rat
title_sort role of the sympathetic nervous system in the control of the goitrogenic response in the rat
publishDate 1981
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v109_n6_p2202_Pisarev
http://hdl.handle.net/20.500.12110/paper_00137227_v109_n6_p2202_Pisarev
_version_ 1768543495396524032