pH front tracking in the electrochemical treatment (EChT) of tumors: Experiments and simulations

The extreme cathodic and anodic pH fronts induced in the electrochemical treatment of tumors (EChT) are the main cause of tumor necrosis. Here, we study pH fronts interaction in a tissue under EChT through in vitro and in silico modeling. The in vitro model considers the tumor tissue as a buffered g...

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Autores principales: Turjanski, Pablo Guillermo, Suárez, Cecilia Ana
Publicado: 2009
Materias:
Electroacupuncture
Electrochemical treatment
Mathematical modeling
Numerical simulation
Tumor
Electrochemical treatments
Experimental measurements
Front tracking
In-silico
In-silico models
In-vitro
Ion transports
Nernst-Planck equations
Neutral pH
Strong correlation
Tumor necrosis
Tumor tissues
Computer simulation languages
Gelation
Oncology
Sodium chloride
Tumors
Simulators
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00134686_v54_n26_p6199_Turjanski
http://hdl.handle.net/20.500.12110/paper_00134686_v54_n26_p6199_Turjanski
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00134686_v54_n26_p6199_Turjanski
record_format dspace
spelling paper:paper_00134686_v54_n26_p6199_Turjanski2023-06-08T14:35:58Z pH front tracking in the electrochemical treatment (EChT) of tumors: Experiments and simulations Turjanski, Pablo Guillermo Suárez, Cecilia Ana Electroacupuncture Electrochemical treatment Mathematical modeling Numerical simulation Tumor Electrochemical treatment Electrochemical treatments Experimental measurements Front tracking In-silico In-silico models In-vitro Ion transports Mathematical modeling Nernst-Planck equations Neutral pH Numerical simulation Strong correlation Tumor necrosis Tumor tissues Computer simulation languages Electroacupuncture Gelation Oncology Sodium chloride Tumors Simulators The extreme cathodic and anodic pH fronts induced in the electrochemical treatment of tumors (EChT) are the main cause of tumor necrosis. Here, we study pH fronts interaction in a tissue under EChT through in vitro and in silico modeling. The in vitro model considers the tumor tissue as a buffered gel with saline (NaCl) content and the cathodic treated area as the area of phenolphtalein virage. The in silico model solves the 1D Nernst-Planck equations for ion transport in a four-ion electrolyte. In silico modeling predicts an initial neutral pH profile evolving into extreme cathodic alkaline and anodic acidic fronts moving towards each other and colliding, thus excluding the existence of a biological pH region between them. Moreover, the model predicts that as electric current increases, pH front scaling grows as t1, unveiling a transition from a diffusion to a migration governed regime. Theory and simulations have a strong correlation with experimental measurements. Since necrotic areas correlate well with those covered by alkaline and acid fronts advance, pH front tracking can be used to predict the extent of tumor destruction and thus, the assessment of EChT effectiveness. © 2009 Elsevier Ltd. All rights reserved. Fil:Turjanski, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Suárez, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00134686_v54_n26_p6199_Turjanski http://hdl.handle.net/20.500.12110/paper_00134686_v54_n26_p6199_Turjanski
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Electroacupuncture
Electrochemical treatment
Mathematical modeling
Numerical simulation
Tumor
Electrochemical treatment
Electrochemical treatments
Experimental measurements
Front tracking
In-silico
In-silico models
In-vitro
Ion transports
Mathematical modeling
Nernst-Planck equations
Neutral pH
Numerical simulation
Strong correlation
Tumor necrosis
Tumor tissues
Computer simulation languages
Electroacupuncture
Gelation
Oncology
Sodium chloride
Tumors
Simulators
spellingShingle Electroacupuncture
Electrochemical treatment
Mathematical modeling
Numerical simulation
Tumor
Electrochemical treatment
Electrochemical treatments
Experimental measurements
Front tracking
In-silico
In-silico models
In-vitro
Ion transports
Mathematical modeling
Nernst-Planck equations
Neutral pH
Numerical simulation
Strong correlation
Tumor necrosis
Tumor tissues
Computer simulation languages
Electroacupuncture
Gelation
Oncology
Sodium chloride
Tumors
Simulators
Turjanski, Pablo Guillermo
Suárez, Cecilia Ana
pH front tracking in the electrochemical treatment (EChT) of tumors: Experiments and simulations
topic_facet Electroacupuncture
Electrochemical treatment
Mathematical modeling
Numerical simulation
Tumor
Electrochemical treatment
Electrochemical treatments
Experimental measurements
Front tracking
In-silico
In-silico models
In-vitro
Ion transports
Mathematical modeling
Nernst-Planck equations
Neutral pH
Numerical simulation
Strong correlation
Tumor necrosis
Tumor tissues
Computer simulation languages
Electroacupuncture
Gelation
Oncology
Sodium chloride
Tumors
Simulators
description The extreme cathodic and anodic pH fronts induced in the electrochemical treatment of tumors (EChT) are the main cause of tumor necrosis. Here, we study pH fronts interaction in a tissue under EChT through in vitro and in silico modeling. The in vitro model considers the tumor tissue as a buffered gel with saline (NaCl) content and the cathodic treated area as the area of phenolphtalein virage. The in silico model solves the 1D Nernst-Planck equations for ion transport in a four-ion electrolyte. In silico modeling predicts an initial neutral pH profile evolving into extreme cathodic alkaline and anodic acidic fronts moving towards each other and colliding, thus excluding the existence of a biological pH region between them. Moreover, the model predicts that as electric current increases, pH front scaling grows as t1, unveiling a transition from a diffusion to a migration governed regime. Theory and simulations have a strong correlation with experimental measurements. Since necrotic areas correlate well with those covered by alkaline and acid fronts advance, pH front tracking can be used to predict the extent of tumor destruction and thus, the assessment of EChT effectiveness. © 2009 Elsevier Ltd. All rights reserved.
author Turjanski, Pablo Guillermo
Suárez, Cecilia Ana
author_facet Turjanski, Pablo Guillermo
Suárez, Cecilia Ana
author_sort Turjanski, Pablo Guillermo
title pH front tracking in the electrochemical treatment (EChT) of tumors: Experiments and simulations
title_short pH front tracking in the electrochemical treatment (EChT) of tumors: Experiments and simulations
title_full pH front tracking in the electrochemical treatment (EChT) of tumors: Experiments and simulations
title_fullStr pH front tracking in the electrochemical treatment (EChT) of tumors: Experiments and simulations
title_full_unstemmed pH front tracking in the electrochemical treatment (EChT) of tumors: Experiments and simulations
title_sort ph front tracking in the electrochemical treatment (echt) of tumors: experiments and simulations
publishDate 2009
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00134686_v54_n26_p6199_Turjanski
http://hdl.handle.net/20.500.12110/paper_00134686_v54_n26_p6199_Turjanski
work_keys_str_mv AT turjanskipabloguillermo phfronttrackingintheelectrochemicaltreatmentechtoftumorsexperimentsandsimulations
AT suarezceciliaana phfronttrackingintheelectrochemicaltreatmentechtoftumorsexperimentsandsimulations
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