Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis

The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the...

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Autores principales:	Rosignoli, Florencia, Roca, Valeria Inés, Pérez Leirós, Claudia
Publicado:	2005
Materias:	Autoimmune response Nitric oxide signalling NOD mice Sialadenitis Sjögren's syndrome cyclic AMP cyclic GMP neurotransmitter nitric oxide nitric oxide synthase vasoactive intestinal polypeptide animal experiment animal model animal tissue article autoimmunity cell infiltration cytokine production enzyme activity female immune response mononuclear cell mouse mouse strain nonhuman parotid gland priority journal salivary gland salivation sialoadenitis signal transduction Sjoegren syndrome submandibular gland Animals Autoantibodies Autoimmunity Cyclic GMP Cytokines Diabetes Mellitus, Type 1 Disease Models, Animal Female Mice Mice, Inbred BALB C Mice, Inbred NOD Nitric Oxide Synthase Parotid Gland Salivary Glands Signal Transduction Submandibular Gland Vasoactive Intestinal Peptide
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v142_n3_p411_Rosignoli http://hdl.handle.net/20.500.12110/paper_00099104_v142_n3_p411_Rosignoli
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00099104_v142_n3_p411_Rosignoli
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spelling	paper:paper_00099104_v142_n3_p411_Rosignoli2023-06-08T14:34:07Z Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis Rosignoli, Florencia Roca, Valeria Inés Pérez Leirós, Claudia Autoimmune response Nitric oxide signalling NOD mice Sialadenitis Sjögren's syndrome cyclic AMP cyclic GMP neurotransmitter nitric oxide nitric oxide synthase vasoactive intestinal polypeptide animal experiment animal model animal tissue article autoimmunity cell infiltration cytokine production enzyme activity female immune response mononuclear cell mouse mouse strain nonhuman parotid gland priority journal salivary gland salivation sialoadenitis signal transduction Sjoegren syndrome submandibular gland Animals Autoantibodies Autoimmunity Cyclic GMP Cytokines Diabetes Mellitus, Type 1 Disease Models, Animal Female Mice Mice, Inbred BALB C Mice, Inbred NOD Nitric Oxide Synthase Parotid Gland Salivary Glands Sialadenitis Signal Transduction Submandibular Gland Vasoactive Intestinal Peptide The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the autoimmune response and alterations in various signalling pathways involved in saliva secretion within each salivary gland. A progressive loss of nitric oxide synthase activity in submandibular and parotid glands started at 12 weeks of age and paralleled the decline in salivary secretion. This defect was associated with a lower response to vasoactive intestinal peptide in salivary flow rate, cAMP and nitric oxide/cGMP production. No signs of mononuclear infiltrates or local cytokine production were detectable in salivary glands in the time period studied (10-16 weeks of age). Our data support a disease model for sialadenitis in NOD mice in which the early stages are characterized by defective neurotransmitter-mediated signalling in major salivary glands that precedes the autoimmune response. © 2005 British Society for Immunology. Fil:Rosignoli, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Roca, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Leirós, C.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v142_n3_p411_Rosignoli http://hdl.handle.net/20.500.12110/paper_00099104_v142_n3_p411_Rosignoli
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Autoimmune response Nitric oxide signalling NOD mice Sialadenitis Sjögren's syndrome cyclic AMP cyclic GMP neurotransmitter nitric oxide nitric oxide synthase vasoactive intestinal polypeptide animal experiment animal model animal tissue article autoimmunity cell infiltration cytokine production enzyme activity female immune response mononuclear cell mouse mouse strain nonhuman parotid gland priority journal salivary gland salivation sialoadenitis signal transduction Sjoegren syndrome submandibular gland Animals Autoantibodies Autoimmunity Cyclic GMP Cytokines Diabetes Mellitus, Type 1 Disease Models, Animal Female Mice Mice, Inbred BALB C Mice, Inbred NOD Nitric Oxide Synthase Parotid Gland Salivary Glands Sialadenitis Signal Transduction Submandibular Gland Vasoactive Intestinal Peptide
spellingShingle	Autoimmune response Nitric oxide signalling NOD mice Sialadenitis Sjögren's syndrome cyclic AMP cyclic GMP neurotransmitter nitric oxide nitric oxide synthase vasoactive intestinal polypeptide animal experiment animal model animal tissue article autoimmunity cell infiltration cytokine production enzyme activity female immune response mononuclear cell mouse mouse strain nonhuman parotid gland priority journal salivary gland salivation sialoadenitis signal transduction Sjoegren syndrome submandibular gland Animals Autoantibodies Autoimmunity Cyclic GMP Cytokines Diabetes Mellitus, Type 1 Disease Models, Animal Female Mice Mice, Inbred BALB C Mice, Inbred NOD Nitric Oxide Synthase Parotid Gland Salivary Glands Sialadenitis Signal Transduction Submandibular Gland Vasoactive Intestinal Peptide Rosignoli, Florencia Roca, Valeria Inés Pérez Leirós, Claudia Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
topic_facet	Autoimmune response Nitric oxide signalling NOD mice Sialadenitis Sjögren's syndrome cyclic AMP cyclic GMP neurotransmitter nitric oxide nitric oxide synthase vasoactive intestinal polypeptide animal experiment animal model animal tissue article autoimmunity cell infiltration cytokine production enzyme activity female immune response mononuclear cell mouse mouse strain nonhuman parotid gland priority journal salivary gland salivation sialoadenitis signal transduction Sjoegren syndrome submandibular gland Animals Autoantibodies Autoimmunity Cyclic GMP Cytokines Diabetes Mellitus, Type 1 Disease Models, Animal Female Mice Mice, Inbred BALB C Mice, Inbred NOD Nitric Oxide Synthase Parotid Gland Salivary Glands Sialadenitis Signal Transduction Submandibular Gland Vasoactive Intestinal Peptide
description	The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the autoimmune response and alterations in various signalling pathways involved in saliva secretion within each salivary gland. A progressive loss of nitric oxide synthase activity in submandibular and parotid glands started at 12 weeks of age and paralleled the decline in salivary secretion. This defect was associated with a lower response to vasoactive intestinal peptide in salivary flow rate, cAMP and nitric oxide/cGMP production. No signs of mononuclear infiltrates or local cytokine production were detectable in salivary glands in the time period studied (10-16 weeks of age). Our data support a disease model for sialadenitis in NOD mice in which the early stages are characterized by defective neurotransmitter-mediated signalling in major salivary glands that precedes the autoimmune response. © 2005 British Society for Immunology.
author	Rosignoli, Florencia Roca, Valeria Inés Pérez Leirós, Claudia
author_facet	Rosignoli, Florencia Roca, Valeria Inés Pérez Leirós, Claudia
author_sort	Rosignoli, Florencia
title	Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_short	Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_full	Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_fullStr	Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_full_unstemmed	Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_sort	defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
publishDate	2005
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v142_n3_p411_Rosignoli http://hdl.handle.net/20.500.12110/paper_00099104_v142_n3_p411_Rosignoli
work_keys_str_mv	AT rosignoliflorencia defectivesignallinginsalivaryglandsprecedestheautoimmuneresponseinthenonobesediabeticmousemodelofsialadenitis AT rocavaleriaines defectivesignallinginsalivaryglandsprecedestheautoimmuneresponseinthenonobesediabeticmousemodelofsialadenitis AT perezleirosclaudia defectivesignallinginsalivaryglandsprecedestheautoimmuneresponseinthenonobesediabeticmousemodelofsialadenitis
_version_	1768544621770571776

Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis

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