Telomerase activity in fine needle aspiration biopsy samples: Application to diagnosis of human thyroid carcinoma
Background: The diagnosis of thyroid follicular carcinoma by fine needle aspiration biopsy is a well known problem in thyroid pathology. Methods: We evaluated telomerase activity (TA) in 85 fine needle aspiration biopsy (FNAB) samples from patients with thyroid nodules. Surgery samples from patients...
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paper:paper_00098981_v370_n1-2_p180_Guerra2023-06-08T14:34:06Z Telomerase activity in fine needle aspiration biopsy samples: Application to diagnosis of human thyroid carcinoma Guerra, Liliana Noemí Miler, Eliana Andrea Fine needle aspiration biopsy Telomerase Thyroid cancer telomerase article aspiration biopsy cancer cytodiagnosis cell labeling controlled study cytopathology enzyme activity false negative result false positive result histopathology human human tissue major clinical study needle biopsy papillary carcinoma priority journal sample size thyroid carcinoma thyroid follicular carcinoma thyroid nodule tissue section Biopsy, Fine-Needle Humans Telomerase Thyroid Neoplasms Tumor Markers, Biological Tumor Suppressor Protein p53 Background: The diagnosis of thyroid follicular carcinoma by fine needle aspiration biopsy is a well known problem in thyroid pathology. Methods: We evaluated telomerase activity (TA) in 85 fine needle aspiration biopsy (FNAB) samples from patients with thyroid nodules. Surgery samples from patients with tumor or follicular adenomas were also analyzed. Results: Twenty of the FNAB samples corresponded to carcinomas and were positive to telomerase assay (TA > 10 Units). Among them, 4 follicular carcinomas and 1 papillary carcinoma were labeled as indeterminate by FNAB cytological examination. Four percent false positive cases and no false negative cases for TA in FNABs were reported. FNAB samples from follicular adenomas were diagnosed as indeterminate by cytological examination, but they showed no detectable TA. Tumor tissues from patients with follicular or papillary thyroid carcinomas presented TA > 10 Units, whereas follicular adenoma tissues (benign nodules) showed no TA. Conclusion: Our results showed a good correlation between TA in FNAB samples and tumor/nodule thyroid tissue. This suggested that use of TA as a biological marker of malignancy might be a useful tool in the diagnosis of follicular thyroid carcinomas or follicular thyroid adenomas using FNAB samples. © 2006 Elsevier B.V. All rights reserved. Fil:Guerra, L.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Miler, E.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00098981_v370_n1-2_p180_Guerra http://hdl.handle.net/20.500.12110/paper_00098981_v370_n1-2_p180_Guerra |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Fine needle aspiration biopsy Telomerase Thyroid cancer telomerase article aspiration biopsy cancer cytodiagnosis cell labeling controlled study cytopathology enzyme activity false negative result false positive result histopathology human human tissue major clinical study needle biopsy papillary carcinoma priority journal sample size thyroid carcinoma thyroid follicular carcinoma thyroid nodule tissue section Biopsy, Fine-Needle Humans Telomerase Thyroid Neoplasms Tumor Markers, Biological Tumor Suppressor Protein p53 |
spellingShingle |
Fine needle aspiration biopsy Telomerase Thyroid cancer telomerase article aspiration biopsy cancer cytodiagnosis cell labeling controlled study cytopathology enzyme activity false negative result false positive result histopathology human human tissue major clinical study needle biopsy papillary carcinoma priority journal sample size thyroid carcinoma thyroid follicular carcinoma thyroid nodule tissue section Biopsy, Fine-Needle Humans Telomerase Thyroid Neoplasms Tumor Markers, Biological Tumor Suppressor Protein p53 Guerra, Liliana Noemí Miler, Eliana Andrea Telomerase activity in fine needle aspiration biopsy samples: Application to diagnosis of human thyroid carcinoma |
topic_facet |
Fine needle aspiration biopsy Telomerase Thyroid cancer telomerase article aspiration biopsy cancer cytodiagnosis cell labeling controlled study cytopathology enzyme activity false negative result false positive result histopathology human human tissue major clinical study needle biopsy papillary carcinoma priority journal sample size thyroid carcinoma thyroid follicular carcinoma thyroid nodule tissue section Biopsy, Fine-Needle Humans Telomerase Thyroid Neoplasms Tumor Markers, Biological Tumor Suppressor Protein p53 |
description |
Background: The diagnosis of thyroid follicular carcinoma by fine needle aspiration biopsy is a well known problem in thyroid pathology. Methods: We evaluated telomerase activity (TA) in 85 fine needle aspiration biopsy (FNAB) samples from patients with thyroid nodules. Surgery samples from patients with tumor or follicular adenomas were also analyzed. Results: Twenty of the FNAB samples corresponded to carcinomas and were positive to telomerase assay (TA > 10 Units). Among them, 4 follicular carcinomas and 1 papillary carcinoma were labeled as indeterminate by FNAB cytological examination. Four percent false positive cases and no false negative cases for TA in FNABs were reported. FNAB samples from follicular adenomas were diagnosed as indeterminate by cytological examination, but they showed no detectable TA. Tumor tissues from patients with follicular or papillary thyroid carcinomas presented TA > 10 Units, whereas follicular adenoma tissues (benign nodules) showed no TA. Conclusion: Our results showed a good correlation between TA in FNAB samples and tumor/nodule thyroid tissue. This suggested that use of TA as a biological marker of malignancy might be a useful tool in the diagnosis of follicular thyroid carcinomas or follicular thyroid adenomas using FNAB samples. © 2006 Elsevier B.V. All rights reserved. |
author |
Guerra, Liliana Noemí Miler, Eliana Andrea |
author_facet |
Guerra, Liliana Noemí Miler, Eliana Andrea |
author_sort |
Guerra, Liliana Noemí |
title |
Telomerase activity in fine needle aspiration biopsy samples: Application to diagnosis of human thyroid carcinoma |
title_short |
Telomerase activity in fine needle aspiration biopsy samples: Application to diagnosis of human thyroid carcinoma |
title_full |
Telomerase activity in fine needle aspiration biopsy samples: Application to diagnosis of human thyroid carcinoma |
title_fullStr |
Telomerase activity in fine needle aspiration biopsy samples: Application to diagnosis of human thyroid carcinoma |
title_full_unstemmed |
Telomerase activity in fine needle aspiration biopsy samples: Application to diagnosis of human thyroid carcinoma |
title_sort |
telomerase activity in fine needle aspiration biopsy samples: application to diagnosis of human thyroid carcinoma |
publishDate |
2006 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00098981_v370_n1-2_p180_Guerra http://hdl.handle.net/20.500.12110/paper_00098981_v370_n1-2_p180_Guerra |
work_keys_str_mv |
AT guerraliliananoemi telomeraseactivityinfineneedleaspirationbiopsysamplesapplicationtodiagnosisofhumanthyroidcarcinoma AT milerelianaandrea telomeraseactivityinfineneedleaspirationbiopsysamplesapplicationtodiagnosisofhumanthyroidcarcinoma |
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