Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine
Severe porphyria was induced and maintained for several months in rats by means of daily hexachlorobenzene administration via stomach tube. Urinary porphyrins with 8-, 7-, 6-, 5- and 4-COOH were isolated and studied by column and paper Chromatographic techniques, both qualitative and quantitative, a...
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1970
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00098981_v28_n1_p13_deViale http://hdl.handle.net/20.500.12110/paper_00098981_v28_n1_p13_deViale |
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paper:paper_00098981_v28_n1_p13_deViale2023-06-08T14:34:04Z Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine benzene derivative chlorine insecticide lindane porphyrin animal article chromatography female human iatrogenic disease male metabolism microphotography paper chromatography porphyria rat spectrophotometry urine Animal Benzene Derivatives Chlorine Chromatography Chromatography, Paper Female Human Insecticides, Botanical Lindane Male Photomicrography Porphyria Porphyrins Rats Spectrophotometry Severe porphyria was induced and maintained for several months in rats by means of daily hexachlorobenzene administration via stomach tube. Urinary porphyrins with 8-, 7-, 6-, 5- and 4-COOH were isolated and studied by column and paper Chromatographic techniques, both qualitative and quantitative, and their absorption spectra and melting points were determined. It was found that the relative excretory pattern was: uroporphyrin > coproporphyrin > phyriaporphyrins > 5-COOH porphyrin > 6-COOH porphyrin. By chemical decarboxylation, all these porphyrins were found to be the type III isomer with only traces of uroporphyrin I and 5-COOH porphyrin I. The predominant porphyrins in the liver were uroporphyrin III and phyriaporphyrin. These findings were compared with those reported in humans intoxicated with the same chemical and with those in patients with hepatic porphyria cutanea tarda. The main differences among these groups were in the isomeric composition of the uroporphyrin, 5-COOH porphyrin and coproporphyrin. Porphyria induced in rats by hexachlorobenzene appears to provide a useful experimental approach for the study of the metabolic changes involved in human porphyria. © 1970. 1970 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00098981_v28_n1_p13_deViale http://hdl.handle.net/20.500.12110/paper_00098981_v28_n1_p13_deViale |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
benzene derivative chlorine insecticide lindane porphyrin animal article chromatography female human iatrogenic disease male metabolism microphotography paper chromatography porphyria rat spectrophotometry urine Animal Benzene Derivatives Chlorine Chromatography Chromatography, Paper Female Human Insecticides, Botanical Lindane Male Photomicrography Porphyria Porphyrins Rats Spectrophotometry |
| spellingShingle |
benzene derivative chlorine insecticide lindane porphyrin animal article chromatography female human iatrogenic disease male metabolism microphotography paper chromatography porphyria rat spectrophotometry urine Animal Benzene Derivatives Chlorine Chromatography Chromatography, Paper Female Human Insecticides, Botanical Lindane Male Photomicrography Porphyria Porphyrins Rats Spectrophotometry Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine |
| topic_facet |
benzene derivative chlorine insecticide lindane porphyrin animal article chromatography female human iatrogenic disease male metabolism microphotography paper chromatography porphyria rat spectrophotometry urine Animal Benzene Derivatives Chlorine Chromatography Chromatography, Paper Female Human Insecticides, Botanical Lindane Male Photomicrography Porphyria Porphyrins Rats Spectrophotometry |
| description |
Severe porphyria was induced and maintained for several months in rats by means of daily hexachlorobenzene administration via stomach tube. Urinary porphyrins with 8-, 7-, 6-, 5- and 4-COOH were isolated and studied by column and paper Chromatographic techniques, both qualitative and quantitative, and their absorption spectra and melting points were determined. It was found that the relative excretory pattern was: uroporphyrin > coproporphyrin > phyriaporphyrins > 5-COOH porphyrin > 6-COOH porphyrin. By chemical decarboxylation, all these porphyrins were found to be the type III isomer with only traces of uroporphyrin I and 5-COOH porphyrin I. The predominant porphyrins in the liver were uroporphyrin III and phyriaporphyrin. These findings were compared with those reported in humans intoxicated with the same chemical and with those in patients with hepatic porphyria cutanea tarda. The main differences among these groups were in the isomeric composition of the uroporphyrin, 5-COOH porphyrin and coproporphyrin. Porphyria induced in rats by hexachlorobenzene appears to provide a useful experimental approach for the study of the metabolic changes involved in human porphyria. © 1970. |
| title |
Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine |
| title_short |
Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine |
| title_full |
Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine |
| title_fullStr |
Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine |
| title_full_unstemmed |
Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine |
| title_sort |
experimental porphyria induced in rats by hexachloro-benzene. a study of the porphyrins excreted by urine |
| publishDate |
1970 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00098981_v28_n1_p13_deViale http://hdl.handle.net/20.500.12110/paper_00098981_v28_n1_p13_deViale |
| _version_ |
1768541588499202048 |