Anti-adenovirus activity of epiandrosterone and dehydroepiandrosterone derivatives

Background: Dehydroepiandrosterone (DHEA) exhibits a wide range of biological functions including antiviral activity. In this work, we present in vitro anti-adenovirus (AdV) activity of seven DHEA and twelve epiandrosterone (EA) analogues. Methods: The cytotoxic effect of the compounds was determine...

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Autores principales:	Romanutti, Carina, Bruttomesso, Andrea Claudia, Castilla, Viviana, Wachsman, Mónica Beatriz
Publicado:	2010
Materias:	Adenovirus Anti-adenovirus activity Antiviral activity Dehydroepiandrosterone analogues DHEA 16alpha hydroxyprasterone 17 oxo 5alpha androstan 3beta yl acetate 17 oxo 5alpha androstan 3beta,16alpha diyl diacetate 17 oxo 5alpha androstan 3beta,16beta diyl diacetate 17 oxoandrost 5 en 3beta yl acetate 17 oxoandrost 5 en 3beta,16alpha diyl diacetate 17,17 ethylendioxy 5alpha androst 15 en 3beta ol 17,17 ethylendioxy 5alpha androstan 16alpha bromo 3beta ol 17,17 ethylendioxy 5alpha androstan 3beta ol 17,17 ethylendioxy 5alpha androstan 3beta yl acetate 17,17 ethylendioxyandrost 5 en 3beta ol 21 norpregna 5,17(20) dien 3beta,16alpha diyl diacetate 3beta hydroxy 5alpha androst 15 en 17 one 3beta,15alpha dihydroxy 5alpha androstan 17 one 3beta,15beta dihydroxy 5alpha androstan 17 one 3beta,16alpha dihydroxy 5alpha androstan 17 one 3beta,6alpha dihydroxy 5alpha androstan 17 one androsta 5,16 dien 3beta,17 diyl diacetate antivirus agent cidofovir epiandrosterone prasterone unclassified drug virus protein antiviral activity article controlled study drug cytotoxicity drug mechanism drug selectivity drug structure human human cell in vitro study priority journal protein synthesis regulation virus attachment virus entry virus inhibition virus particle virus replication Western blotting Adenoviridae Androsterone Animals Antiviral Agents Blotting, Western Cercopithecus aethiops Cytosine Dehydroepiandrosterone Humans Mice Phosphonic Acids Vero Cells Viral Proteins Virus Replication
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v56_n2_p158_Romanutti http://hdl.handle.net/20.500.12110/paper_00093157_v56_n2_p158_Romanutti
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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