The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans

The sulfated agaran isolated by water extraction from the red seaweed, Acanthophora spicifera (Rhodomelaceae, Ceramiales), is made up of A-units highly substituted with sulfate groups on C-2 (28-30%), sulfates on C-2 and 4,6-O-(1′-carboxyethylidene) groups (9-15%), and only the C-2 sulfate groups (5...

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Autores principales:	Noseda, Miguel D., Pujol, Carlos Alberto, Damonte, Elsa Beatriz, Cerezo, Alberto Saúl
Publicado:	2004
Materias:	Acanthophora spicifera Antiviral activity Chemical structure Herpes simplex virus Methylation analysis NMR spectroscopy Rhodomelaceae Seaweed Sulfated agarans Glucose Sulfur compounds Viruses 2 o methyl alpha galactose 3,6 anhydro alpha galactose 3,6 anhydro alpha galactose 2 sulfate agaran sulfate alpha galactose 2,3,6 trisulfate alpha galactose 2,6 disulfate alpha galactose 2,6 disulfate 3 xylose alpha galactose 6 sulfate beta xylose galactose sulfate unclassified drug water xylose acanthophora spicifera animal cell antiviral activity article controlled study correlation analysis drug structure extraction nonhuman priority journal quantitative analysis seaweed structure activity relation structure analysis sulfation Acanthophora algae Ceramiales Simplexvirus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v339_n2_p335_Duarte http://hdl.handle.net/20.500.12110/paper_00086215_v339_n2_p335_Duarte
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00086215_v339_n2_p335_Duarte
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spelling	paper:paper_00086215_v339_n2_p335_Duarte2023-06-08T14:32:46Z The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans Noseda, Miguel D. Pujol, Carlos Alberto Damonte, Elsa Beatriz Cerezo, Alberto Saúl Acanthophora spicifera Antiviral activity Chemical structure Herpes simplex virus Methylation analysis NMR spectroscopy Rhodomelaceae Seaweed Sulfated agarans Glucose Sulfur compounds Viruses Antiviral activity Seaweed 2 o methyl alpha galactose 3,6 anhydro alpha galactose 3,6 anhydro alpha galactose 2 sulfate agaran sulfate alpha galactose 2,3,6 trisulfate alpha galactose 2,6 disulfate alpha galactose 2,6 disulfate 3 xylose alpha galactose 6 sulfate beta xylose galactose sulfate unclassified drug water xylose acanthophora spicifera animal cell antiviral activity article controlled study correlation analysis drug structure extraction nonhuman priority journal quantitative analysis seaweed structure activity relation structure analysis sulfation Acanthophora Acanthophora spicifera algae Ceramiales Rhodomelaceae Simplexvirus The sulfated agaran isolated by water extraction from the red seaweed, Acanthophora spicifera (Rhodomelaceae, Ceramiales), is made up of A-units highly substituted with sulfate groups on C-2 (28-30%), sulfates on C-2 and 4,6-O-(1′-carboxyethylidene) groups (9-15%), and only the C-2 sulfate groups (5-8%) with small amounts of C-6 sulfate, 6-O-methyl, and nonsubstituted residues. B-units are formed mainly by 3,6-anhydro-α-L-galactose (15-16%) and its precursor, α-L-galactose 6-sulfate (10-17%), together with lesser amounts of 3,6-anhydro-α-L-galactose 2-sulfate, α-L-galactose 2,6-disulfate, α-L-galactose 2,3,6-tri-sulfate, α-L-galactose 2,6-disulfate 3-xylose, 2-O-methyl-α-L-galactose, and unsubstituted α-L-galactose. Small, but significant quantities of β-D-xylose were found in all the fractions, together with small amounts to traces of D-glucose. Some of the fractions have high antiviral activity. Attempts to correlate structure and antiviral activity in agarans are presented. © 2003 Elsevier Ltd. All rights reserved. Fil:Noseda, M.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pujol, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cerezo, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2004 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v339_n2_p335_Duarte http://hdl.handle.net/20.500.12110/paper_00086215_v339_n2_p335_Duarte
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Acanthophora spicifera Antiviral activity Chemical structure Herpes simplex virus Methylation analysis NMR spectroscopy Rhodomelaceae Seaweed Sulfated agarans Glucose Sulfur compounds Viruses Antiviral activity Seaweed 2 o methyl alpha galactose 3,6 anhydro alpha galactose 3,6 anhydro alpha galactose 2 sulfate agaran sulfate alpha galactose 2,3,6 trisulfate alpha galactose 2,6 disulfate alpha galactose 2,6 disulfate 3 xylose alpha galactose 6 sulfate beta xylose galactose sulfate unclassified drug water xylose acanthophora spicifera animal cell antiviral activity article controlled study correlation analysis drug structure extraction nonhuman priority journal quantitative analysis seaweed structure activity relation structure analysis sulfation Acanthophora Acanthophora spicifera algae Ceramiales Rhodomelaceae Simplexvirus
spellingShingle	Acanthophora spicifera Antiviral activity Chemical structure Herpes simplex virus Methylation analysis NMR spectroscopy Rhodomelaceae Seaweed Sulfated agarans Glucose Sulfur compounds Viruses Antiviral activity Seaweed 2 o methyl alpha galactose 3,6 anhydro alpha galactose 3,6 anhydro alpha galactose 2 sulfate agaran sulfate alpha galactose 2,3,6 trisulfate alpha galactose 2,6 disulfate alpha galactose 2,6 disulfate 3 xylose alpha galactose 6 sulfate beta xylose galactose sulfate unclassified drug water xylose acanthophora spicifera animal cell antiviral activity article controlled study correlation analysis drug structure extraction nonhuman priority journal quantitative analysis seaweed structure activity relation structure analysis sulfation Acanthophora Acanthophora spicifera algae Ceramiales Rhodomelaceae Simplexvirus Noseda, Miguel D. Pujol, Carlos Alberto Damonte, Elsa Beatriz Cerezo, Alberto Saúl The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans
topic_facet	Acanthophora spicifera Antiviral activity Chemical structure Herpes simplex virus Methylation analysis NMR spectroscopy Rhodomelaceae Seaweed Sulfated agarans Glucose Sulfur compounds Viruses Antiviral activity Seaweed 2 o methyl alpha galactose 3,6 anhydro alpha galactose 3,6 anhydro alpha galactose 2 sulfate agaran sulfate alpha galactose 2,3,6 trisulfate alpha galactose 2,6 disulfate alpha galactose 2,6 disulfate 3 xylose alpha galactose 6 sulfate beta xylose galactose sulfate unclassified drug water xylose acanthophora spicifera animal cell antiviral activity article controlled study correlation analysis drug structure extraction nonhuman priority journal quantitative analysis seaweed structure activity relation structure analysis sulfation Acanthophora Acanthophora spicifera algae Ceramiales Rhodomelaceae Simplexvirus
description	The sulfated agaran isolated by water extraction from the red seaweed, Acanthophora spicifera (Rhodomelaceae, Ceramiales), is made up of A-units highly substituted with sulfate groups on C-2 (28-30%), sulfates on C-2 and 4,6-O-(1′-carboxyethylidene) groups (9-15%), and only the C-2 sulfate groups (5-8%) with small amounts of C-6 sulfate, 6-O-methyl, and nonsubstituted residues. B-units are formed mainly by 3,6-anhydro-α-L-galactose (15-16%) and its precursor, α-L-galactose 6-sulfate (10-17%), together with lesser amounts of 3,6-anhydro-α-L-galactose 2-sulfate, α-L-galactose 2,6-disulfate, α-L-galactose 2,3,6-tri-sulfate, α-L-galactose 2,6-disulfate 3-xylose, 2-O-methyl-α-L-galactose, and unsubstituted α-L-galactose. Small, but significant quantities of β-D-xylose were found in all the fractions, together with small amounts to traces of D-glucose. Some of the fractions have high antiviral activity. Attempts to correlate structure and antiviral activity in agarans are presented. © 2003 Elsevier Ltd. All rights reserved.
author	Noseda, Miguel D. Pujol, Carlos Alberto Damonte, Elsa Beatriz Cerezo, Alberto Saúl
author_facet	Noseda, Miguel D. Pujol, Carlos Alberto Damonte, Elsa Beatriz Cerezo, Alberto Saúl
author_sort	Noseda, Miguel D.
title	The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans
title_short	The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans
title_full	The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans
title_fullStr	The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans
title_full_unstemmed	The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans
title_sort	structure of the agaran sulfate from acanthophora spicifera (rhodomelaceae, ceramiales) and its antiviral activity. relation between structure and antiviral activity in agarans
publishDate	2004
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v339_n2_p335_Duarte http://hdl.handle.net/20.500.12110/paper_00086215_v339_n2_p335_Duarte
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The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans

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