The system of sulfated α-(1 → 3)-linked D-mannans from the red seaweed Nothogenia fastigiata: Structures, antiherpetic and anticoagulant properties
Structural analysis of two xylomannans extracted from Nothogenia fastigiata was carried out. The results are consistent with the general pattern previously reported for other xylo-mannans of the same system, α-(1 → 3)-linked D-mannans 2- and 6-sulfated and having single stubs of β-(1 → 2)-linked D-x...
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1997
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v304_n1_p53_Kolender http://hdl.handle.net/20.500.12110/paper_00086215_v304_n1_p53_Kolender |
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paper:paper_00086215_v304_n1_p53_Kolender2023-06-08T14:32:35Z The system of sulfated α-(1 → 3)-linked D-mannans from the red seaweed Nothogenia fastigiata: Structures, antiherpetic and anticoagulant properties Kolender, Adriana Andrea Pujol, Carlos Alberto Damonte, Elsa Beatriz Matulewicz, María Cristina Cerezo, Alberto Saúl α-(1 → 3)-Linked mannans α-(1 → 3)-Linked mannans, Sulfated Antiherpetic activity Xylomannans Xylomannans, sulfated anticoagulant agent antivirus agent galactose mannan mannose natural product unclassified drug xylomannan xylose anticoagulation antiviral activity article carbon nuclear magnetic resonance chemical structure herpes simplex herpes simplex virus marine environment nonhuman priority journal proton nuclear magnetic resonance seaweed sulfation thrombin time virus inhibition Anticoagulants Antiviral Agents Carbohydrate Conformation Galactans Galactose Magnetic Resonance Spectroscopy Mannans Mannose Molecular Weight Seaweed Simplexvirus Sulfates Xylans Xylose algae Herpes Nothogenia fastigiata Simplexvirus Structural analysis of two xylomannans extracted from Nothogenia fastigiata was carried out. The results are consistent with the general pattern previously reported for other xylo-mannans of the same system, α-(1 → 3)-linked D-mannans 2- and 6-sulfated and having single stubs of β-(1 → 2)-linked D-xylose, but one of the new samples contains a significant amount of 2,6-disulfated units. Both xylomannans studied are obtained as complexes with a β-D-(1 → 3)-, α-L-(1 → 4)-galactan and a β-D-(1 → 3)-, β-D-(1 → 4)-'mixed linkage' xylan co-existing in the seaweed, a fact that limits the accuracy of the data determined. The structures of the galactan and the xylan are similar to those previously informed for this seaweed. The antiviral activity against four different herpes simplex viral strains and the anticoagulant properties of all the xylo-mannans of the system are reported. Fil:Kolender, A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pujol, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Matulewicz, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cerezo, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v304_n1_p53_Kolender http://hdl.handle.net/20.500.12110/paper_00086215_v304_n1_p53_Kolender |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
α-(1 → 3)-Linked mannans α-(1 → 3)-Linked mannans, Sulfated Antiherpetic activity Xylomannans Xylomannans, sulfated anticoagulant agent antivirus agent galactose mannan mannose natural product unclassified drug xylomannan xylose anticoagulation antiviral activity article carbon nuclear magnetic resonance chemical structure herpes simplex herpes simplex virus marine environment nonhuman priority journal proton nuclear magnetic resonance seaweed sulfation thrombin time virus inhibition Anticoagulants Antiviral Agents Carbohydrate Conformation Galactans Galactose Magnetic Resonance Spectroscopy Mannans Mannose Molecular Weight Seaweed Simplexvirus Sulfates Xylans Xylose algae Herpes Nothogenia fastigiata Simplexvirus |
| spellingShingle |
α-(1 → 3)-Linked mannans α-(1 → 3)-Linked mannans, Sulfated Antiherpetic activity Xylomannans Xylomannans, sulfated anticoagulant agent antivirus agent galactose mannan mannose natural product unclassified drug xylomannan xylose anticoagulation antiviral activity article carbon nuclear magnetic resonance chemical structure herpes simplex herpes simplex virus marine environment nonhuman priority journal proton nuclear magnetic resonance seaweed sulfation thrombin time virus inhibition Anticoagulants Antiviral Agents Carbohydrate Conformation Galactans Galactose Magnetic Resonance Spectroscopy Mannans Mannose Molecular Weight Seaweed Simplexvirus Sulfates Xylans Xylose algae Herpes Nothogenia fastigiata Simplexvirus Kolender, Adriana Andrea Pujol, Carlos Alberto Damonte, Elsa Beatriz Matulewicz, María Cristina Cerezo, Alberto Saúl The system of sulfated α-(1 → 3)-linked D-mannans from the red seaweed Nothogenia fastigiata: Structures, antiherpetic and anticoagulant properties |
| topic_facet |
α-(1 → 3)-Linked mannans α-(1 → 3)-Linked mannans, Sulfated Antiherpetic activity Xylomannans Xylomannans, sulfated anticoagulant agent antivirus agent galactose mannan mannose natural product unclassified drug xylomannan xylose anticoagulation antiviral activity article carbon nuclear magnetic resonance chemical structure herpes simplex herpes simplex virus marine environment nonhuman priority journal proton nuclear magnetic resonance seaweed sulfation thrombin time virus inhibition Anticoagulants Antiviral Agents Carbohydrate Conformation Galactans Galactose Magnetic Resonance Spectroscopy Mannans Mannose Molecular Weight Seaweed Simplexvirus Sulfates Xylans Xylose algae Herpes Nothogenia fastigiata Simplexvirus |
| description |
Structural analysis of two xylomannans extracted from Nothogenia fastigiata was carried out. The results are consistent with the general pattern previously reported for other xylo-mannans of the same system, α-(1 → 3)-linked D-mannans 2- and 6-sulfated and having single stubs of β-(1 → 2)-linked D-xylose, but one of the new samples contains a significant amount of 2,6-disulfated units. Both xylomannans studied are obtained as complexes with a β-D-(1 → 3)-, α-L-(1 → 4)-galactan and a β-D-(1 → 3)-, β-D-(1 → 4)-'mixed linkage' xylan co-existing in the seaweed, a fact that limits the accuracy of the data determined. The structures of the galactan and the xylan are similar to those previously informed for this seaweed. The antiviral activity against four different herpes simplex viral strains and the anticoagulant properties of all the xylo-mannans of the system are reported. |
| author |
Kolender, Adriana Andrea Pujol, Carlos Alberto Damonte, Elsa Beatriz Matulewicz, María Cristina Cerezo, Alberto Saúl |
| author_facet |
Kolender, Adriana Andrea Pujol, Carlos Alberto Damonte, Elsa Beatriz Matulewicz, María Cristina Cerezo, Alberto Saúl |
| author_sort |
Kolender, Adriana Andrea |
| title |
The system of sulfated α-(1 → 3)-linked D-mannans from the red seaweed Nothogenia fastigiata: Structures, antiherpetic and anticoagulant properties |
| title_short |
The system of sulfated α-(1 → 3)-linked D-mannans from the red seaweed Nothogenia fastigiata: Structures, antiherpetic and anticoagulant properties |
| title_full |
The system of sulfated α-(1 → 3)-linked D-mannans from the red seaweed Nothogenia fastigiata: Structures, antiherpetic and anticoagulant properties |
| title_fullStr |
The system of sulfated α-(1 → 3)-linked D-mannans from the red seaweed Nothogenia fastigiata: Structures, antiherpetic and anticoagulant properties |
| title_full_unstemmed |
The system of sulfated α-(1 → 3)-linked D-mannans from the red seaweed Nothogenia fastigiata: Structures, antiherpetic and anticoagulant properties |
| title_sort |
system of sulfated α-(1 → 3)-linked d-mannans from the red seaweed nothogenia fastigiata: structures, antiherpetic and anticoagulant properties |
| publishDate |
1997 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v304_n1_p53_Kolender http://hdl.handle.net/20.500.12110/paper_00086215_v304_n1_p53_Kolender |
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