Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor β
Bidirectional cross-talk between the neuroendocrine and immune systems orchestrates immune responses in both physiologic and pathologic settings. In this study, we provide in vivo evidence of a critical role for the thyroid hormone triiodothyronine (T3) in controlling the maturation and antitumor fu...
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2015
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00085472_v75_n7_p1265_Alamino http://hdl.handle.net/20.500.12110/paper_00085472_v75_n7_p1265_Alamino |
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paper:paper_00085472_v75_n7_p1265_Alamino2023-06-08T14:32:08Z Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor β cytokine gamma interferon liothyronine thyroid hormone thyroid hormone receptor beta liothyronine thyroid hormone receptor beta animal cell animal experiment animal model antigen presenting cell antigen specificity Article cancer immunotherapy CD8+ T lymphocyte cell migration cell viability controlled study cytokine production cytotoxic T lymphocyte dendritic cell female immune response in vivo study innate immunity lymph node melanoma mouse nonhuman priority journal receptor binding T lymphocyte tumor growth animal C57BL mouse cell motion cell survival cross presentation cytotoxicity dendritic cell immunology immunotherapy Melanoma, Experimental metabolism transgenic mouse Animals CD8-Positive T-Lymphocytes Cell Movement Cell Survival Cross-Priming Cytotoxicity, Immunologic Dendritic Cells Female Immunotherapy Lymph Nodes Melanoma, Experimental Mice, Inbred C57BL Mice, Transgenic Thyroid Hormone Receptors beta Triiodothyronine Bidirectional cross-talk between the neuroendocrine and immune systems orchestrates immune responses in both physiologic and pathologic settings. In this study, we provide in vivo evidence of a critical role for the thyroid hormone triiodothyronine (T3) in controlling the maturation and antitumor functions of dendritic cells (DC). We used a thyroid hormone receptor (TR) β mutant mouse (TRβPV) to establish the relevance of the T3-TRβ system in vivo. In this model, TRβ signaling endowed DCs with the ability to stimulate antigen-specific cytotoxic T-cell responses during tumor development. T3 binding to TRβ increased DC viability and augmented DC migration to lymph nodes. Moreover, T3 stimulated the ability of DCs to cross-present antigens and to stimulate cytotoxic T-cell responses. In a B16-OVA mouse model of melanoma, vaccination with T3-stimulated DCs inhibited tumor growth and prolonged host survival, in part by promoting the generation of IFNγ-producing CD8+ T cells. Overall, our results establish an adjuvant effect of T3-TRβ signaling in DCs, suggesting an immediately translatable method to empower DC vaccination approaches for cancer immunotherapy. ©2015 AACR. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00085472_v75_n7_p1265_Alamino http://hdl.handle.net/20.500.12110/paper_00085472_v75_n7_p1265_Alamino |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
cytokine gamma interferon liothyronine thyroid hormone thyroid hormone receptor beta liothyronine thyroid hormone receptor beta animal cell animal experiment animal model antigen presenting cell antigen specificity Article cancer immunotherapy CD8+ T lymphocyte cell migration cell viability controlled study cytokine production cytotoxic T lymphocyte dendritic cell female immune response in vivo study innate immunity lymph node melanoma mouse nonhuman priority journal receptor binding T lymphocyte tumor growth animal C57BL mouse cell motion cell survival cross presentation cytotoxicity dendritic cell immunology immunotherapy Melanoma, Experimental metabolism transgenic mouse Animals CD8-Positive T-Lymphocytes Cell Movement Cell Survival Cross-Priming Cytotoxicity, Immunologic Dendritic Cells Female Immunotherapy Lymph Nodes Melanoma, Experimental Mice, Inbred C57BL Mice, Transgenic Thyroid Hormone Receptors beta Triiodothyronine |
| spellingShingle |
cytokine gamma interferon liothyronine thyroid hormone thyroid hormone receptor beta liothyronine thyroid hormone receptor beta animal cell animal experiment animal model antigen presenting cell antigen specificity Article cancer immunotherapy CD8+ T lymphocyte cell migration cell viability controlled study cytokine production cytotoxic T lymphocyte dendritic cell female immune response in vivo study innate immunity lymph node melanoma mouse nonhuman priority journal receptor binding T lymphocyte tumor growth animal C57BL mouse cell motion cell survival cross presentation cytotoxicity dendritic cell immunology immunotherapy Melanoma, Experimental metabolism transgenic mouse Animals CD8-Positive T-Lymphocytes Cell Movement Cell Survival Cross-Priming Cytotoxicity, Immunologic Dendritic Cells Female Immunotherapy Lymph Nodes Melanoma, Experimental Mice, Inbred C57BL Mice, Transgenic Thyroid Hormone Receptors beta Triiodothyronine Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor β |
| topic_facet |
cytokine gamma interferon liothyronine thyroid hormone thyroid hormone receptor beta liothyronine thyroid hormone receptor beta animal cell animal experiment animal model antigen presenting cell antigen specificity Article cancer immunotherapy CD8+ T lymphocyte cell migration cell viability controlled study cytokine production cytotoxic T lymphocyte dendritic cell female immune response in vivo study innate immunity lymph node melanoma mouse nonhuman priority journal receptor binding T lymphocyte tumor growth animal C57BL mouse cell motion cell survival cross presentation cytotoxicity dendritic cell immunology immunotherapy Melanoma, Experimental metabolism transgenic mouse Animals CD8-Positive T-Lymphocytes Cell Movement Cell Survival Cross-Priming Cytotoxicity, Immunologic Dendritic Cells Female Immunotherapy Lymph Nodes Melanoma, Experimental Mice, Inbred C57BL Mice, Transgenic Thyroid Hormone Receptors beta Triiodothyronine |
| description |
Bidirectional cross-talk between the neuroendocrine and immune systems orchestrates immune responses in both physiologic and pathologic settings. In this study, we provide in vivo evidence of a critical role for the thyroid hormone triiodothyronine (T3) in controlling the maturation and antitumor functions of dendritic cells (DC). We used a thyroid hormone receptor (TR) β mutant mouse (TRβPV) to establish the relevance of the T3-TRβ system in vivo. In this model, TRβ signaling endowed DCs with the ability to stimulate antigen-specific cytotoxic T-cell responses during tumor development. T3 binding to TRβ increased DC viability and augmented DC migration to lymph nodes. Moreover, T3 stimulated the ability of DCs to cross-present antigens and to stimulate cytotoxic T-cell responses. In a B16-OVA mouse model of melanoma, vaccination with T3-stimulated DCs inhibited tumor growth and prolonged host survival, in part by promoting the generation of IFNγ-producing CD8+ T cells. Overall, our results establish an adjuvant effect of T3-TRβ signaling in DCs, suggesting an immediately translatable method to empower DC vaccination approaches for cancer immunotherapy. ©2015 AACR. |
| title |
Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor β |
| title_short |
Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor β |
| title_full |
Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor β |
| title_fullStr |
Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor β |
| title_full_unstemmed |
Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor β |
| title_sort |
antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor β |
| publishDate |
2015 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00085472_v75_n7_p1265_Alamino http://hdl.handle.net/20.500.12110/paper_00085472_v75_n7_p1265_Alamino |
| _version_ |
1768542719145148416 |