Positive modulation of the α9α10 nicotinic cholinergic receptor by ascorbic acid

Background and Purpose The activation of α9α10 nicotinic cholinergic receptors (nAChRs) present at the synapse between efferent olivocochlear fibres and cochlear hair cells can prevent acoustic trauma. Hence, pharmacological potentiators of these receptors could be useful therapeutically. In this wo...

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Guardado en:
Detalles Bibliográficos
Publicado: 2013
Materias:
acoustic trauma
ascorbate
ascorbic acid
efferent olivocochlear
hearing loss
nicotinic receptor
positive allosteric modulator
redox modulation
vitamin C
acetylcholine
alpha9alpha10 nicotinic cholinergic receptor
cysteine
unclassified drug
amino acid substitution
animal cell
article
binding site
concentration response
controlled study
drug mechanism
evoked response
nonhuman
oocyte
point mutation
priority journal
protein domain
protein expression
Xenopus laevis
Animals
Antioxidants
Ascorbic Acid
Dose-Response Relationship, Drug
Evoked Potentials
Models, Molecular
Oocytes
Patch-Clamp Techniques
Receptors, Nicotinic
Recombinant Fusion Proteins
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00071188_v168_n4_p954_Boffi
http://hdl.handle.net/20.500.12110/paper_00071188_v168_n4_p954_Boffi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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