Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion
Meningiomas are tumours derived from the arachnoid and pia mater. During embryogenesis, these membranes develop from the migrating craniofacial neural crest. We have previously demonstrated that meningiomas have characteristic features of embryonic meninges. Craniofacial neural crest derivatives are...
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1999
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00070920_v81_n3_p381_PaezPereda http://hdl.handle.net/20.500.12110/paper_00070920_v81_n3_p381_PaezPereda |
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paper:paper_00070920_v81_n3_p381_PaezPereda2023-06-08T14:31:33Z Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion Páez Pereda, Marcelo Cell adhesion Meningioma Retinoic acid Tumour invasion collagen type 1 fibronectin gelatinase a gelatinase b matrix metalloproteinase retinoic acid article cancer invasion cell adhesion cell proliferation cell viability controlled study embryo development extracellular matrix human human cell meningioma neural crest phenotype priority journal Cell Adhesion Cell Division Collagenases Culture Media, Conditioned Extracellular Matrix Gelatinases Humans Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Meningeal Neoplasms Meningioma Metalloendopeptidases Neoplasm Invasiveness Neoplasm Proteins Tretinoin Tumor Cells, Cultured Meningiomas are tumours derived from the arachnoid and pia mater. During embryogenesis, these membranes develop from the migrating craniofacial neural crest. We have previously demonstrated that meningiomas have characteristic features of embryonic meninges. Craniofacial neural crest derivatives are affected during normal development and migration by retinoic acid. We speculated, therefore, that meningioma cell migration and invasion would be affected in a similar way. In this study we investigated the mechanisms of invasion and migration in meningiomas and the effects of retinoic acid (RA). We found that low doses of RA inhibit in vitro invasion in meningioma cells, without affecting cell proliferation or viability. The matrix metalloproteinases MMP-2 (72 kDa gelatinase) and MMP-9 (92 kDa gelatinase), which play a key role in invasion in other tumours, are not affected by RA. RA inhibits cell migration on collagen I and fibronectin. A possible mechanism for these effects is provided by the fact that RA strongly stimulates adhesion of meningioma cells to extracellular matrix substrates. As in vitro invasion, migration and decreased adhesion to the extracellular matrix correlate with the clinical manifestation of tumour invasion, we conclude that RA induces a non-invasive phenotype in meningioma cells. Fil:Páez Pereda, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1999 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00070920_v81_n3_p381_PaezPereda http://hdl.handle.net/20.500.12110/paper_00070920_v81_n3_p381_PaezPereda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cell adhesion Meningioma Retinoic acid Tumour invasion collagen type 1 fibronectin gelatinase a gelatinase b matrix metalloproteinase retinoic acid article cancer invasion cell adhesion cell proliferation cell viability controlled study embryo development extracellular matrix human human cell meningioma neural crest phenotype priority journal Cell Adhesion Cell Division Collagenases Culture Media, Conditioned Extracellular Matrix Gelatinases Humans Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Meningeal Neoplasms Meningioma Metalloendopeptidases Neoplasm Invasiveness Neoplasm Proteins Tretinoin Tumor Cells, Cultured |
| spellingShingle |
Cell adhesion Meningioma Retinoic acid Tumour invasion collagen type 1 fibronectin gelatinase a gelatinase b matrix metalloproteinase retinoic acid article cancer invasion cell adhesion cell proliferation cell viability controlled study embryo development extracellular matrix human human cell meningioma neural crest phenotype priority journal Cell Adhesion Cell Division Collagenases Culture Media, Conditioned Extracellular Matrix Gelatinases Humans Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Meningeal Neoplasms Meningioma Metalloendopeptidases Neoplasm Invasiveness Neoplasm Proteins Tretinoin Tumor Cells, Cultured Páez Pereda, Marcelo Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion |
| topic_facet |
Cell adhesion Meningioma Retinoic acid Tumour invasion collagen type 1 fibronectin gelatinase a gelatinase b matrix metalloproteinase retinoic acid article cancer invasion cell adhesion cell proliferation cell viability controlled study embryo development extracellular matrix human human cell meningioma neural crest phenotype priority journal Cell Adhesion Cell Division Collagenases Culture Media, Conditioned Extracellular Matrix Gelatinases Humans Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Meningeal Neoplasms Meningioma Metalloendopeptidases Neoplasm Invasiveness Neoplasm Proteins Tretinoin Tumor Cells, Cultured |
| description |
Meningiomas are tumours derived from the arachnoid and pia mater. During embryogenesis, these membranes develop from the migrating craniofacial neural crest. We have previously demonstrated that meningiomas have characteristic features of embryonic meninges. Craniofacial neural crest derivatives are affected during normal development and migration by retinoic acid. We speculated, therefore, that meningioma cell migration and invasion would be affected in a similar way. In this study we investigated the mechanisms of invasion and migration in meningiomas and the effects of retinoic acid (RA). We found that low doses of RA inhibit in vitro invasion in meningioma cells, without affecting cell proliferation or viability. The matrix metalloproteinases MMP-2 (72 kDa gelatinase) and MMP-9 (92 kDa gelatinase), which play a key role in invasion in other tumours, are not affected by RA. RA inhibits cell migration on collagen I and fibronectin. A possible mechanism for these effects is provided by the fact that RA strongly stimulates adhesion of meningioma cells to extracellular matrix substrates. As in vitro invasion, migration and decreased adhesion to the extracellular matrix correlate with the clinical manifestation of tumour invasion, we conclude that RA induces a non-invasive phenotype in meningioma cells. |
| author |
Páez Pereda, Marcelo |
| author_facet |
Páez Pereda, Marcelo |
| author_sort |
Páez Pereda, Marcelo |
| title |
Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion |
| title_short |
Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion |
| title_full |
Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion |
| title_fullStr |
Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion |
| title_full_unstemmed |
Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion |
| title_sort |
retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion |
| publishDate |
1999 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00070920_v81_n3_p381_PaezPereda http://hdl.handle.net/20.500.12110/paper_00070920_v81_n3_p381_PaezPereda |
| work_keys_str_mv |
AT paezperedamarcelo retinoicacidstimulatesmeningiomacelladhesiontotheextracellularmatrixandinhibitsinvasion |
| _version_ |
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