Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes
The influence of diabetes mellitus on brain pathology is increasingly recognized. Previous contributions of our laboratory demonstrated in models of type 1 diabetes (nonobese diabetic and streptozotocin (STZ)-treated mice), a marked astrogliosis and neurogenesis deficit in hippocampus and increased...
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2005
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068993_v1038_n1_p22_Revsin http://hdl.handle.net/20.500.12110/paper_00068993_v1038_n1_p22_Revsin |
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paper:paper_00068993_v1038_n1_p22_Revsin |
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paper:paper_00068993_v1038_n1_p22_Revsin2023-06-08T14:31:28Z Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes Apolipoprotein-E, Fos, Jun, NADPH-diaphorase Astrocytes Diabetes mellitus Hippocampus Neurodegeneration Neurons Streptozotocin apolipoprotein E gene product molecular marker protein c fos protein c jun reduced nicotinamide adenine dinucleotide phosphate dehydrogenase streptozocin animal experiment animal model animal tissue article brain cortex brain region cell activation cell count controlled study dentate gyrus enzyme activity female gene expression gene mutation genetic analysis genetic linkage hippocampus insulin dependent diabetes mellitus macroglia mouse nerve cell lesion nonhuman oxidative stress priority journal streptozocin diabetes The influence of diabetes mellitus on brain pathology is increasingly recognized. Previous contributions of our laboratory demonstrated in models of type 1 diabetes (nonobese diabetic and streptozotocin (STZ)-treated mice), a marked astrogliosis and neurogenesis deficit in hippocampus and increased expression of hypothalamic neuropeptides. In the present investigation, we further analyzed alterations of astroglia and neurons in the hippocampus of mice 1 month after STZ-induced diabetes. Results showed that these STZ-diabetic mice presented: (a) increased number of astrocytes positive for apolipoprotein-E (Apo-E), a marker of ongoing neuronal dysfunction; (b) abnormal expression of early gene products associated with neuronal activation, including a high number of Jun + neurons in CA1 and CA3 layers and dentate gyrus, and of Fos-expressing neurons in CA3 layer; (c) augmented activity of NADPH-diaphorase, linked to oxidative stress, in CA3 region. These data support the concept that uncontrolled diabetes leads to hippocampal pathology, which adjoin to changes in other brain structures such as hypothalamus and cerebral cortex. © 2005 Elsevier B.V. All rights reserved. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068993_v1038_n1_p22_Revsin http://hdl.handle.net/20.500.12110/paper_00068993_v1038_n1_p22_Revsin |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Apolipoprotein-E, Fos, Jun, NADPH-diaphorase Astrocytes Diabetes mellitus Hippocampus Neurodegeneration Neurons Streptozotocin apolipoprotein E gene product molecular marker protein c fos protein c jun reduced nicotinamide adenine dinucleotide phosphate dehydrogenase streptozocin animal experiment animal model animal tissue article brain cortex brain region cell activation cell count controlled study dentate gyrus enzyme activity female gene expression gene mutation genetic analysis genetic linkage hippocampus insulin dependent diabetes mellitus macroglia mouse nerve cell lesion nonhuman oxidative stress priority journal streptozocin diabetes |
| spellingShingle |
Apolipoprotein-E, Fos, Jun, NADPH-diaphorase Astrocytes Diabetes mellitus Hippocampus Neurodegeneration Neurons Streptozotocin apolipoprotein E gene product molecular marker protein c fos protein c jun reduced nicotinamide adenine dinucleotide phosphate dehydrogenase streptozocin animal experiment animal model animal tissue article brain cortex brain region cell activation cell count controlled study dentate gyrus enzyme activity female gene expression gene mutation genetic analysis genetic linkage hippocampus insulin dependent diabetes mellitus macroglia mouse nerve cell lesion nonhuman oxidative stress priority journal streptozocin diabetes Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes |
| topic_facet |
Apolipoprotein-E, Fos, Jun, NADPH-diaphorase Astrocytes Diabetes mellitus Hippocampus Neurodegeneration Neurons Streptozotocin apolipoprotein E gene product molecular marker protein c fos protein c jun reduced nicotinamide adenine dinucleotide phosphate dehydrogenase streptozocin animal experiment animal model animal tissue article brain cortex brain region cell activation cell count controlled study dentate gyrus enzyme activity female gene expression gene mutation genetic analysis genetic linkage hippocampus insulin dependent diabetes mellitus macroglia mouse nerve cell lesion nonhuman oxidative stress priority journal streptozocin diabetes |
| description |
The influence of diabetes mellitus on brain pathology is increasingly recognized. Previous contributions of our laboratory demonstrated in models of type 1 diabetes (nonobese diabetic and streptozotocin (STZ)-treated mice), a marked astrogliosis and neurogenesis deficit in hippocampus and increased expression of hypothalamic neuropeptides. In the present investigation, we further analyzed alterations of astroglia and neurons in the hippocampus of mice 1 month after STZ-induced diabetes. Results showed that these STZ-diabetic mice presented: (a) increased number of astrocytes positive for apolipoprotein-E (Apo-E), a marker of ongoing neuronal dysfunction; (b) abnormal expression of early gene products associated with neuronal activation, including a high number of Jun + neurons in CA1 and CA3 layers and dentate gyrus, and of Fos-expressing neurons in CA3 layer; (c) augmented activity of NADPH-diaphorase, linked to oxidative stress, in CA3 region. These data support the concept that uncontrolled diabetes leads to hippocampal pathology, which adjoin to changes in other brain structures such as hypothalamus and cerebral cortex. © 2005 Elsevier B.V. All rights reserved. |
| title |
Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes |
| title_short |
Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes |
| title_full |
Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes |
| title_fullStr |
Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes |
| title_full_unstemmed |
Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes |
| title_sort |
neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes |
| publishDate |
2005 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068993_v1038_n1_p22_Revsin http://hdl.handle.net/20.500.12110/paper_00068993_v1038_n1_p22_Revsin |
| _version_ |
1768545674567090176 |