Early detection of intentional harm in the human amygdala
A decisive element of moral cognition is the detection of harm and its assessment as intentional or unintentional. Moral cognition engages brain networks supporting mentalizing, intentionality, empathic concern and evaluation. These networks rely on the amygdala as a critical hub, likely through fro...
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068950_v139_n1_p54_Hesse http://hdl.handle.net/20.500.12110/paper_00068950_v139_n1_p54_Hesse |
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paper:paper_00068950_v139_n1_p54_Hesse2023-06-08T14:31:27Z Early detection of intentional harm in the human amygdala Sigman, Mariano Bekinschtein, Tristán Andres Amygdala Intentional harm Intracranial recordings Moral cognition adult amygdala Article case report cognition comparative study connectome controlled study depth electrode electric potential electroencephalogram electrophysiological procedures eye tracking female frontal cortex functional magnetic resonance imaging functional neuroimaging human intentional harm male middle aged morality parietal cortex priority journal stimulus response task performance temporal cortex young adult aggression amygdala behavior cognition electrode implant eye movement morality physiology psychomotor performance reproducibility Adult Aggression Amygdala Cognition Electrodes, Implanted Eye Movements Female Humans Intention Male Middle Aged Morals Psychomotor Performance Reproducibility of Results Young Adult A decisive element of moral cognition is the detection of harm and its assessment as intentional or unintentional. Moral cognition engages brain networks supporting mentalizing, intentionality, empathic concern and evaluation. These networks rely on the amygdala as a critical hub, likely through frontotemporal connections indexing stimulus salience. We assessed inferences about perceived harm using a paradigm validated through functional magnetic resonance imaging, eye-tracking and electroencephalogram recordings. During the task, we measured local field potentials in three patients with depth electrodes (n = 115) placed in the amygdala and in several frontal, temporal, and parietal locations. Direct electrophysiological recordings demonstrate that intentional harm induces early activity in the amygdala (5 200 ms), which-in turn-predicts intention attribution. The amygdala was the only site that systematically discriminated between critical conditions and predicted their classification of events as intentional. Moreover, connectivity analysis showed that intentional harm induced stronger frontotemporal information sharing at early stages. Results support the 'many roads' view of the amygdala and highlight its role in the rapid encoding of intention and salience-critical components of mentalizing and moral evaluation. © The Author (2015). Fil:Sigman, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bekinschtein, T.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068950_v139_n1_p54_Hesse http://hdl.handle.net/20.500.12110/paper_00068950_v139_n1_p54_Hesse |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Amygdala Intentional harm Intracranial recordings Moral cognition adult amygdala Article case report cognition comparative study connectome controlled study depth electrode electric potential electroencephalogram electrophysiological procedures eye tracking female frontal cortex functional magnetic resonance imaging functional neuroimaging human intentional harm male middle aged morality parietal cortex priority journal stimulus response task performance temporal cortex young adult aggression amygdala behavior cognition electrode implant eye movement morality physiology psychomotor performance reproducibility Adult Aggression Amygdala Cognition Electrodes, Implanted Eye Movements Female Humans Intention Male Middle Aged Morals Psychomotor Performance Reproducibility of Results Young Adult |
| spellingShingle |
Amygdala Intentional harm Intracranial recordings Moral cognition adult amygdala Article case report cognition comparative study connectome controlled study depth electrode electric potential electroencephalogram electrophysiological procedures eye tracking female frontal cortex functional magnetic resonance imaging functional neuroimaging human intentional harm male middle aged morality parietal cortex priority journal stimulus response task performance temporal cortex young adult aggression amygdala behavior cognition electrode implant eye movement morality physiology psychomotor performance reproducibility Adult Aggression Amygdala Cognition Electrodes, Implanted Eye Movements Female Humans Intention Male Middle Aged Morals Psychomotor Performance Reproducibility of Results Young Adult Sigman, Mariano Bekinschtein, Tristán Andres Early detection of intentional harm in the human amygdala |
| topic_facet |
Amygdala Intentional harm Intracranial recordings Moral cognition adult amygdala Article case report cognition comparative study connectome controlled study depth electrode electric potential electroencephalogram electrophysiological procedures eye tracking female frontal cortex functional magnetic resonance imaging functional neuroimaging human intentional harm male middle aged morality parietal cortex priority journal stimulus response task performance temporal cortex young adult aggression amygdala behavior cognition electrode implant eye movement morality physiology psychomotor performance reproducibility Adult Aggression Amygdala Cognition Electrodes, Implanted Eye Movements Female Humans Intention Male Middle Aged Morals Psychomotor Performance Reproducibility of Results Young Adult |
| description |
A decisive element of moral cognition is the detection of harm and its assessment as intentional or unintentional. Moral cognition engages brain networks supporting mentalizing, intentionality, empathic concern and evaluation. These networks rely on the amygdala as a critical hub, likely through frontotemporal connections indexing stimulus salience. We assessed inferences about perceived harm using a paradigm validated through functional magnetic resonance imaging, eye-tracking and electroencephalogram recordings. During the task, we measured local field potentials in three patients with depth electrodes (n = 115) placed in the amygdala and in several frontal, temporal, and parietal locations. Direct electrophysiological recordings demonstrate that intentional harm induces early activity in the amygdala (5 200 ms), which-in turn-predicts intention attribution. The amygdala was the only site that systematically discriminated between critical conditions and predicted their classification of events as intentional. Moreover, connectivity analysis showed that intentional harm induced stronger frontotemporal information sharing at early stages. Results support the 'many roads' view of the amygdala and highlight its role in the rapid encoding of intention and salience-critical components of mentalizing and moral evaluation. © The Author (2015). |
| author |
Sigman, Mariano Bekinschtein, Tristán Andres |
| author_facet |
Sigman, Mariano Bekinschtein, Tristán Andres |
| author_sort |
Sigman, Mariano |
| title |
Early detection of intentional harm in the human amygdala |
| title_short |
Early detection of intentional harm in the human amygdala |
| title_full |
Early detection of intentional harm in the human amygdala |
| title_fullStr |
Early detection of intentional harm in the human amygdala |
| title_full_unstemmed |
Early detection of intentional harm in the human amygdala |
| title_sort |
early detection of intentional harm in the human amygdala |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068950_v139_n1_p54_Hesse http://hdl.handle.net/20.500.12110/paper_00068950_v139_n1_p54_Hesse |
| work_keys_str_mv |
AT sigmanmariano earlydetectionofintentionalharminthehumanamygdala AT bekinschteintristanandres earlydetectionofintentionalharminthehumanamygdala |
| _version_ |
1768545307978629120 |