Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels
BACKGROUND: The amphiphilic nature of polymers allows them to be widely incorporated as carriers in different pharmaceutical applications since they are able to work as vehicles for hydro-or lipo-soluble actives. OBJECTIVE: The aim of this study was to determine the rheological behavior and vibratio...
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2014
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006355X_v51_n4-5_p315_Tosato http://hdl.handle.net/20.500.12110/paper_0006355X_v51_n4-5_p315_Tosato |
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paper:paper_0006355X_v51_n4-5_p315_Tosato2023-06-08T14:31:20Z Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels gadusol mycosporine-like amino acids Triblock copolymers viscoelastic amino acid derivative antioxidant gadusol poloxamer porphyra 334 shinorine unclassified drug amino acid antioxidant carbon cyclohexanol derivative cyclohexanone derivative cyclohexylamine derivative gadusol gel glycine polymer porphyra-334 shinorine antioxidant activity Article chemical structure conformational transition controlled study covalent bond cross linking female flow kinetics gel gelation hydrophilicity molecular weight nonhuman Porphyra Raman spectrometry tensile strength viscosity analogs and derivatives chemistry flow kinetics gel pH procedures temperature vibration Amino Acids Antioxidants Carbon Cyclohexanols Cyclohexanones Cyclohexylamines Gels Glycine Hydrogen-Ion Concentration Poloxamer Polymers Rheology Spectrum Analysis, Raman Temperature Vibration Viscosity BACKGROUND: The amphiphilic nature of polymers allows them to be widely incorporated as carriers in different pharmaceutical applications since they are able to work as vehicles for hydro-or lipo-soluble actives. OBJECTIVE: The aim of this study was to determine the rheological behavior and vibrational spectral variations of two hydrophilic gels prepared with Poloxamer 407 (PO) or Pluronic F-127 (PL) with the addition of the actives mycosporine-like amino acids and gadusol. METHODS: The structures of these polymers in two different concentrations (20% w/w and 27% w/w) were characterized by rheological studies and Raman spectroscopy. RESULTS: Gels prepared with higher polymer concentration showed larger G′ (storage modulus) values. The C-C stretch and the CH<inf>2</inf> rocking predominated in the gels containing PL (20% w/w) and this correlated with a less viscous behavior. The mixture of the actives induced higher contributions of Raman peaks related to trans conformation of the C-C bonds located in hydrophilic polymer blocks, whereas the same peaks decreased in the sample containing only gadusol. CONCLUSIONS: Larger tensile strength and elastic component were observed upon increasing polymer concentration, thus evidencing polymer-polymer and/or polymer-polymer-actives interactions. The presence of the actives affected the mechanical properties of the polymer gels. Gadusol particularly seems to alter the conformation of the polymer chains by favoring gauche orientations, in parallel with rising viscoelastic parameters. More stretched arrangements of the polymer are probably induced in the presence of larger concentration of actives, due to specific interactions with their hydrophilic groups. © 2014-IOS Press and the authors. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006355X_v51_n4-5_p315_Tosato http://hdl.handle.net/20.500.12110/paper_0006355X_v51_n4-5_p315_Tosato |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
gadusol mycosporine-like amino acids Triblock copolymers viscoelastic amino acid derivative antioxidant gadusol poloxamer porphyra 334 shinorine unclassified drug amino acid antioxidant carbon cyclohexanol derivative cyclohexanone derivative cyclohexylamine derivative gadusol gel glycine polymer porphyra-334 shinorine antioxidant activity Article chemical structure conformational transition controlled study covalent bond cross linking female flow kinetics gel gelation hydrophilicity molecular weight nonhuman Porphyra Raman spectrometry tensile strength viscosity analogs and derivatives chemistry flow kinetics gel pH procedures temperature vibration Amino Acids Antioxidants Carbon Cyclohexanols Cyclohexanones Cyclohexylamines Gels Glycine Hydrogen-Ion Concentration Poloxamer Polymers Rheology Spectrum Analysis, Raman Temperature Vibration Viscosity |
| spellingShingle |
gadusol mycosporine-like amino acids Triblock copolymers viscoelastic amino acid derivative antioxidant gadusol poloxamer porphyra 334 shinorine unclassified drug amino acid antioxidant carbon cyclohexanol derivative cyclohexanone derivative cyclohexylamine derivative gadusol gel glycine polymer porphyra-334 shinorine antioxidant activity Article chemical structure conformational transition controlled study covalent bond cross linking female flow kinetics gel gelation hydrophilicity molecular weight nonhuman Porphyra Raman spectrometry tensile strength viscosity analogs and derivatives chemistry flow kinetics gel pH procedures temperature vibration Amino Acids Antioxidants Carbon Cyclohexanols Cyclohexanones Cyclohexylamines Gels Glycine Hydrogen-Ion Concentration Poloxamer Polymers Rheology Spectrum Analysis, Raman Temperature Vibration Viscosity Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels |
| topic_facet |
gadusol mycosporine-like amino acids Triblock copolymers viscoelastic amino acid derivative antioxidant gadusol poloxamer porphyra 334 shinorine unclassified drug amino acid antioxidant carbon cyclohexanol derivative cyclohexanone derivative cyclohexylamine derivative gadusol gel glycine polymer porphyra-334 shinorine antioxidant activity Article chemical structure conformational transition controlled study covalent bond cross linking female flow kinetics gel gelation hydrophilicity molecular weight nonhuman Porphyra Raman spectrometry tensile strength viscosity analogs and derivatives chemistry flow kinetics gel pH procedures temperature vibration Amino Acids Antioxidants Carbon Cyclohexanols Cyclohexanones Cyclohexylamines Gels Glycine Hydrogen-Ion Concentration Poloxamer Polymers Rheology Spectrum Analysis, Raman Temperature Vibration Viscosity |
| description |
BACKGROUND: The amphiphilic nature of polymers allows them to be widely incorporated as carriers in different pharmaceutical applications since they are able to work as vehicles for hydro-or lipo-soluble actives. OBJECTIVE: The aim of this study was to determine the rheological behavior and vibrational spectral variations of two hydrophilic gels prepared with Poloxamer 407 (PO) or Pluronic F-127 (PL) with the addition of the actives mycosporine-like amino acids and gadusol. METHODS: The structures of these polymers in two different concentrations (20% w/w and 27% w/w) were characterized by rheological studies and Raman spectroscopy. RESULTS: Gels prepared with higher polymer concentration showed larger G′ (storage modulus) values. The C-C stretch and the CH<inf>2</inf> rocking predominated in the gels containing PL (20% w/w) and this correlated with a less viscous behavior. The mixture of the actives induced higher contributions of Raman peaks related to trans conformation of the C-C bonds located in hydrophilic polymer blocks, whereas the same peaks decreased in the sample containing only gadusol. CONCLUSIONS: Larger tensile strength and elastic component were observed upon increasing polymer concentration, thus evidencing polymer-polymer and/or polymer-polymer-actives interactions. The presence of the actives affected the mechanical properties of the polymer gels. Gadusol particularly seems to alter the conformation of the polymer chains by favoring gauche orientations, in parallel with rising viscoelastic parameters. More stretched arrangements of the polymer are probably induced in the presence of larger concentration of actives, due to specific interactions with their hydrophilic groups. © 2014-IOS Press and the authors. |
| title |
Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels |
| title_short |
Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels |
| title_full |
Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels |
| title_fullStr |
Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels |
| title_full_unstemmed |
Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels |
| title_sort |
influence of mycosporine-like amino acids and gadusol on the rheology and raman spectroscopy of polymer gels |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006355X_v51_n4-5_p315_Tosato http://hdl.handle.net/20.500.12110/paper_0006355X_v51_n4-5_p315_Tosato |
| _version_ |
1768543258115309568 |