Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria
The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined. Female Wistar rats were treated with HCB for 1 or 8 weeks. At both treatment times liver weight was notably increased with a slight c...
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1990
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paper:paper_00062952_v39_n5_p817_KleimanDePisarev2023-06-08T14:30:33Z Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria Kleiman de Pisarev, Diana L. Ríos de Molina, María del Carmen San Martín de Viale, Leonor Carmen 5 aminolevulinate synthase hexachlorobenzene propylthiouracil radioisotope thyroxine animal experiment article female liothyronine blood level liver weight nonhuman porphyria priority journal protein bound iodine rat thyroid function thyrotropin blood level thyroxine blood level thyroxine metabolism 5-Aminolevulinate Synthetase Animal Body Weight Chlorobenzenes Dose-Response Relationship, Drug Female Hexachlorobenzene Iodine Radioisotopes Liver Organ Weight Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined. Female Wistar rats were treated with HCB for 1 or 8 weeks. At both treatment times liver weight was notably increased with a slight change in thyroid weight at 8 weeks. Serum thyroxine (T4) levels were depressed, whereas levels of triiodothyronine (T3) were not depressed significantly at both treatment times. One or eight weeks of HCB treatment did not alter the incorporation and distribution of [125I] into intrathyroidal aminoacids. A 50% reduction in protein bound iodine (PB[125I]) was seen in both groups of animals. HCB altered [125I]T4 metabolism in rat liver slices, increasing T4 dehalogenation. HCB administration for 1 week did not affect urinary excretion of porphyrins or their precursors, or hepatic porphyrin content. The activity of aminolaevulinate synthase was not affected, but there was a 25% and 51% inhibition in porphyrinogen carboxy-lyase (PCL) activity for the uroporphyrinogen disappearance or the coproporphyrinogen formation respectively. After 8 weeks of HCB administration the rats showed a characteristic porphyria. Our results show that HCB treatment increased hepatic thyroxine metabolism, without alterations in thyroid hormone synthesis. Serum T4 and PCL activity behaved differently in both time- and dose-dependent studies, with serum T4 being the more sensitive parameter which responded at earlier times and lower doses. © 1990. Fil:Kleiman De Pisarev, D.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Carmen Rios De Molina, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martin De Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1990 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v39_n5_p817_KleimanDePisarev http://hdl.handle.net/20.500.12110/paper_00062952_v39_n5_p817_KleimanDePisarev |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
5 aminolevulinate synthase hexachlorobenzene propylthiouracil radioisotope thyroxine animal experiment article female liothyronine blood level liver weight nonhuman porphyria priority journal protein bound iodine rat thyroid function thyrotropin blood level thyroxine blood level thyroxine metabolism 5-Aminolevulinate Synthetase Animal Body Weight Chlorobenzenes Dose-Response Relationship, Drug Female Hexachlorobenzene Iodine Radioisotopes Liver Organ Weight Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine |
spellingShingle |
5 aminolevulinate synthase hexachlorobenzene propylthiouracil radioisotope thyroxine animal experiment article female liothyronine blood level liver weight nonhuman porphyria priority journal protein bound iodine rat thyroid function thyrotropin blood level thyroxine blood level thyroxine metabolism 5-Aminolevulinate Synthetase Animal Body Weight Chlorobenzenes Dose-Response Relationship, Drug Female Hexachlorobenzene Iodine Radioisotopes Liver Organ Weight Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine Kleiman de Pisarev, Diana L. Ríos de Molina, María del Carmen San Martín de Viale, Leonor Carmen Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria |
topic_facet |
5 aminolevulinate synthase hexachlorobenzene propylthiouracil radioisotope thyroxine animal experiment article female liothyronine blood level liver weight nonhuman porphyria priority journal protein bound iodine rat thyroid function thyrotropin blood level thyroxine blood level thyroxine metabolism 5-Aminolevulinate Synthetase Animal Body Weight Chlorobenzenes Dose-Response Relationship, Drug Female Hexachlorobenzene Iodine Radioisotopes Liver Organ Weight Porphyria Porphyrins Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroxine Triiodothyronine |
description |
The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined. Female Wistar rats were treated with HCB for 1 or 8 weeks. At both treatment times liver weight was notably increased with a slight change in thyroid weight at 8 weeks. Serum thyroxine (T4) levels were depressed, whereas levels of triiodothyronine (T3) were not depressed significantly at both treatment times. One or eight weeks of HCB treatment did not alter the incorporation and distribution of [125I] into intrathyroidal aminoacids. A 50% reduction in protein bound iodine (PB[125I]) was seen in both groups of animals. HCB altered [125I]T4 metabolism in rat liver slices, increasing T4 dehalogenation. HCB administration for 1 week did not affect urinary excretion of porphyrins or their precursors, or hepatic porphyrin content. The activity of aminolaevulinate synthase was not affected, but there was a 25% and 51% inhibition in porphyrinogen carboxy-lyase (PCL) activity for the uroporphyrinogen disappearance or the coproporphyrinogen formation respectively. After 8 weeks of HCB administration the rats showed a characteristic porphyria. Our results show that HCB treatment increased hepatic thyroxine metabolism, without alterations in thyroid hormone synthesis. Serum T4 and PCL activity behaved differently in both time- and dose-dependent studies, with serum T4 being the more sensitive parameter which responded at earlier times and lower doses. © 1990. |
author |
Kleiman de Pisarev, Diana L. Ríos de Molina, María del Carmen San Martín de Viale, Leonor Carmen |
author_facet |
Kleiman de Pisarev, Diana L. Ríos de Molina, María del Carmen San Martín de Viale, Leonor Carmen |
author_sort |
Kleiman de Pisarev, Diana L. |
title |
Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria |
title_short |
Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria |
title_full |
Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria |
title_fullStr |
Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria |
title_full_unstemmed |
Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria |
title_sort |
thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria |
publishDate |
1990 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v39_n5_p817_KleimanDePisarev http://hdl.handle.net/20.500.12110/paper_00062952_v39_n5_p817_KleimanDePisarev |
work_keys_str_mv |
AT kleimandepisarevdianal thyroidfunctionandthyroxinemetabolisminhexachlorobenzeneinducedporphyria AT riosdemolinamariadelcarmen thyroidfunctionandthyroxinemetabolisminhexachlorobenzeneinducedporphyria AT sanmartindevialeleonorcarmen thyroidfunctionandthyroxinemetabolisminhexachlorobenzeneinducedporphyria |
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1768542437749293056 |