Tryptophan metabolism in experimental porphyria
Although there seems to be no qualitative difference in the excretion of certain urinary metabolites of l-tryptophan between normal and porphyric rats, quantitative determination showed that there is a decrease in the level of excretion of l-kynurenine and 3-OH-kynurenine. At the same time, tryptoph...
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| Autores principales: | , |
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| Publicado: |
1967
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v16_n10_p1967_Garcia http://hdl.handle.net/20.500.12110/paper_00062952_v16_n10_p1967_Garcia |
| Aporte de: |
| Sumario: | Although there seems to be no qualitative difference in the excretion of certain urinary metabolites of l-tryptophan between normal and porphyric rats, quantitative determination showed that there is a decrease in the level of excretion of l-kynurenine and 3-OH-kynurenine. At the same time, tryptophan pyrrolase activity is diminished in porphyric animals. This is interpreted as being the result, at least in part, of a competitive inhibition between the porphyrins accumulated in the liver during the state of porphyria and the tryptophan pyrrolase heme coenzyme, for the tryptophan pyrrolase apoenzyme. © 1967. |
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