Tryptophan metabolism in experimental porphyria

Although there seems to be no qualitative difference in the excretion of certain urinary metabolites of l-tryptophan between normal and porphyric rats, quantitative determination showed that there is a decrease in the level of excretion of l-kynurenine and 3-OH-kynurenine. At the same time, tryptoph...

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Detalles Bibliográficos
Autores principales: García, Augusto F., Grinstein, Moisés
Publicado: 1967
Materias:
kynurenine
tryptophan
tryptophan 2,3 dioxygenase
animal
article
chromatography
enzymology
liver
male
metabolism
porphyria
rat
urine
Animal
Chromatography
Kynurenine
Liver
Male
Porphyria
Rats
Tryptophan
Tryptophan Oxygenase
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v16_n10_p1967_Garcia
http://hdl.handle.net/20.500.12110/paper_00062952_v16_n10_p1967_Garcia
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00062952_v16_n10_p1967_Garcia
record_format dspace
spelling paper:paper_00062952_v16_n10_p1967_Garcia2023-06-08T14:30:30Z Tryptophan metabolism in experimental porphyria García, Augusto F. Grinstein, Moisés kynurenine tryptophan tryptophan 2,3 dioxygenase animal article chromatography enzymology liver male metabolism porphyria rat urine Animal Chromatography Kynurenine Liver Male Porphyria Rats Tryptophan Tryptophan Oxygenase Although there seems to be no qualitative difference in the excretion of certain urinary metabolites of l-tryptophan between normal and porphyric rats, quantitative determination showed that there is a decrease in the level of excretion of l-kynurenine and 3-OH-kynurenine. At the same time, tryptophan pyrrolase activity is diminished in porphyric animals. This is interpreted as being the result, at least in part, of a competitive inhibition between the porphyrins accumulated in the liver during the state of porphyria and the tryptophan pyrrolase heme coenzyme, for the tryptophan pyrrolase apoenzyme. © 1967. Fil:Garcia, A.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Grinstein, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1967 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v16_n10_p1967_Garcia http://hdl.handle.net/20.500.12110/paper_00062952_v16_n10_p1967_Garcia
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic kynurenine
tryptophan
tryptophan 2,3 dioxygenase
animal
article
chromatography
enzymology
liver
male
metabolism
porphyria
rat
urine
Animal
Chromatography
Kynurenine
Liver
Male
Porphyria
Rats
Tryptophan
Tryptophan Oxygenase
spellingShingle kynurenine
tryptophan
tryptophan 2,3 dioxygenase
animal
article
chromatography
enzymology
liver
male
metabolism
porphyria
rat
urine
Animal
Chromatography
Kynurenine
Liver
Male
Porphyria
Rats
Tryptophan
Tryptophan Oxygenase
García, Augusto F.
Grinstein, Moisés
Tryptophan metabolism in experimental porphyria
topic_facet kynurenine
tryptophan
tryptophan 2,3 dioxygenase
animal
article
chromatography
enzymology
liver
male
metabolism
porphyria
rat
urine
Animal
Chromatography
Kynurenine
Liver
Male
Porphyria
Rats
Tryptophan
Tryptophan Oxygenase
description Although there seems to be no qualitative difference in the excretion of certain urinary metabolites of l-tryptophan between normal and porphyric rats, quantitative determination showed that there is a decrease in the level of excretion of l-kynurenine and 3-OH-kynurenine. At the same time, tryptophan pyrrolase activity is diminished in porphyric animals. This is interpreted as being the result, at least in part, of a competitive inhibition between the porphyrins accumulated in the liver during the state of porphyria and the tryptophan pyrrolase heme coenzyme, for the tryptophan pyrrolase apoenzyme. © 1967.
author García, Augusto F.
Grinstein, Moisés
author_facet García, Augusto F.
Grinstein, Moisés
author_sort García, Augusto F.
title Tryptophan metabolism in experimental porphyria
title_short Tryptophan metabolism in experimental porphyria
title_full Tryptophan metabolism in experimental porphyria
title_fullStr Tryptophan metabolism in experimental porphyria
title_full_unstemmed Tryptophan metabolism in experimental porphyria
title_sort tryptophan metabolism in experimental porphyria
publishDate 1967
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v16_n10_p1967_Garcia
http://hdl.handle.net/20.500.12110/paper_00062952_v16_n10_p1967_Garcia
work_keys_str_mv AT garciaaugustof tryptophanmetabolisminexperimentalporphyria
AT grinsteinmoises tryptophanmetabolisminexperimentalporphyria
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