Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate
Cyclic AMP inhibits growth rate of E. coli Hfr 3000. Doubling times in glucose minimal medium increased from 60 to about 90 minutes with the addition of 5 mM cAMP. This effect is specific since it was not observed when the cyclic nucleotide was replaced by 5′ AMP, ADP, ATP or adenosine. Half maximal...
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1973
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v52_n4_p1257_Judewicz http://hdl.handle.net/20.500.12110/paper_0006291X_v52_n4_p1257_Judewicz |
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paper:paper_0006291X_v52_n4_p1257_Judewicz2023-06-08T14:30:23Z Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate Judewicz, Norberto D. De Robertis, Eduardo M.F. Torres, Héctor Norberto adenine nucleotide adenosine cyclic AMP galactosidase glucose glycerol malic acid derivative pyruvic acid derivative succinic acid derivative article chemical phenomena drug effect enzymology Escherichia coli growth, development and aging kinetics metabolism Adenine Nucleotides Adenosine Cyclic AMP Depression, Chemical Escherichia coli Galactosidases Glucose Glycerol Kinetics Malates Pyruvates Succinates Cyclic AMP inhibits growth rate of E. coli Hfr 3000. Doubling times in glucose minimal medium increased from 60 to about 90 minutes with the addition of 5 mM cAMP. This effect is specific since it was not observed when the cyclic nucleotide was replaced by 5′ AMP, ADP, ATP or adenosine. Half maximal inhibition was obtained with 1 to 3 mM cyclic AMP. This inhibition occurs only with those carbon sources which are known to decrease intracellular cyclic AMP levels, i.e. glucose and pyruvate. No inhibition was observed with succinate, malate or glycerol. © 1973. Fil:Judewicz, N.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:De Robertis Jr., E.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Torres, H.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1973 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v52_n4_p1257_Judewicz http://hdl.handle.net/20.500.12110/paper_0006291X_v52_n4_p1257_Judewicz |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
adenine nucleotide adenosine cyclic AMP galactosidase glucose glycerol malic acid derivative pyruvic acid derivative succinic acid derivative article chemical phenomena drug effect enzymology Escherichia coli growth, development and aging kinetics metabolism Adenine Nucleotides Adenosine Cyclic AMP Depression, Chemical Escherichia coli Galactosidases Glucose Glycerol Kinetics Malates Pyruvates Succinates |
| spellingShingle |
adenine nucleotide adenosine cyclic AMP galactosidase glucose glycerol malic acid derivative pyruvic acid derivative succinic acid derivative article chemical phenomena drug effect enzymology Escherichia coli growth, development and aging kinetics metabolism Adenine Nucleotides Adenosine Cyclic AMP Depression, Chemical Escherichia coli Galactosidases Glucose Glycerol Kinetics Malates Pyruvates Succinates Judewicz, Norberto D. De Robertis, Eduardo M.F. Torres, Héctor Norberto Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| topic_facet |
adenine nucleotide adenosine cyclic AMP galactosidase glucose glycerol malic acid derivative pyruvic acid derivative succinic acid derivative article chemical phenomena drug effect enzymology Escherichia coli growth, development and aging kinetics metabolism Adenine Nucleotides Adenosine Cyclic AMP Depression, Chemical Escherichia coli Galactosidases Glucose Glycerol Kinetics Malates Pyruvates Succinates |
| description |
Cyclic AMP inhibits growth rate of E. coli Hfr 3000. Doubling times in glucose minimal medium increased from 60 to about 90 minutes with the addition of 5 mM cAMP. This effect is specific since it was not observed when the cyclic nucleotide was replaced by 5′ AMP, ADP, ATP or adenosine. Half maximal inhibition was obtained with 1 to 3 mM cyclic AMP. This inhibition occurs only with those carbon sources which are known to decrease intracellular cyclic AMP levels, i.e. glucose and pyruvate. No inhibition was observed with succinate, malate or glycerol. © 1973. |
| author |
Judewicz, Norberto D. De Robertis, Eduardo M.F. Torres, Héctor Norberto |
| author_facet |
Judewicz, Norberto D. De Robertis, Eduardo M.F. Torres, Héctor Norberto |
| author_sort |
Judewicz, Norberto D. |
| title |
Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| title_short |
Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| title_full |
Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| title_fullStr |
Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| title_full_unstemmed |
Inhibition of Escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| title_sort |
inhibition of escherichia coli growth by cyclic adenosine 3′, 5′-monophosphate |
| publishDate |
1973 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v52_n4_p1257_Judewicz http://hdl.handle.net/20.500.12110/paper_0006291X_v52_n4_p1257_Judewicz |
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AT judewicznorbertod inhibitionofescherichiacoligrowthbycyclicadenosine35monophosphate AT derobertiseduardomf inhibitionofescherichiacoligrowthbycyclicadenosine35monophosphate AT torreshectornorberto inhibitionofescherichiacoligrowthbycyclicadenosine35monophosphate |
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