Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus

The target cell tropism of enveloped viruses is regulated by interactions between viral proteins and cellular receptors determining susceptibility at a host cell, tissue or species level. However, a number of additional cell-surface moieties can also bind viral envelope glycoproteins and could act a...

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Autores principales:	Martínez, María Guadalupe, Cordo, Sandra M., Candurra, Nélida Alicia
Publicado:	2013
Materias:	Junín arenavirus Lectin Virus entry Virus receptor CD209 antigen lectin membrane protein protein l sign unclassified drug article cell surface comparative study controlled study host cell human internalization Junin virus Murine leukemia virus nonhuman priority journal Vesicular stomatitis virus virus culture virus entry virus envelope virus infection virus infectivity virus particle Arenavirus 3T3 Cells Animals Antigens, CD Cell Adhesion Molecules Cercopithecus aethiops Hemorrhagic Fever, American Host-Pathogen Interactions Humans Lectins, C-Type Membrane Glycoproteins Mice Receptors, Cell Surface Receptors, Transferrin Vero Cells Viral Envelope Proteins Virus Internalization
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v441_n3_p612_Martinez http://hdl.handle.net/20.500.12110/paper_0006291X_v441_n3_p612_Martinez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0006291X_v441_n3_p612_Martinez
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spelling	paper:paper_0006291X_v441_n3_p612_Martinez2023-06-08T14:30:21Z Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus Martínez, María Guadalupe Cordo, Sandra M. Candurra, Nélida Alicia Junín arenavirus Lectin Virus entry Virus receptor CD209 antigen lectin membrane protein protein l sign unclassified drug article cell surface comparative study controlled study host cell human internalization Junin virus Murine leukemia virus nonhuman priority journal Vesicular stomatitis virus virus culture virus entry virus envelope virus infection virus infectivity virus particle Arenavirus Junin virus Junín arenavirus Lectin Virus entry Virus receptor 3T3 Cells Animals Antigens, CD Cell Adhesion Molecules Cercopithecus aethiops Hemorrhagic Fever, American Host-Pathogen Interactions Humans Junin virus Lectins, C-Type Membrane Glycoproteins Mice Receptors, Cell Surface Receptors, Transferrin Vero Cells Viral Envelope Proteins Virus Internalization The target cell tropism of enveloped viruses is regulated by interactions between viral proteins and cellular receptors determining susceptibility at a host cell, tissue or species level. However, a number of additional cell-surface moieties can also bind viral envelope glycoproteins and could act as capture receptors, serving as attachment factors to concentrate virus particles on the cell surface, or to disseminate the virus infection to target organs or susceptible cells within the host. Here, we used Junín virus (JUNV) or JUNV glycoprotein complex (GPC)-pseudotyped particles to study their ability to be internalized by the human C-type lectins hDC- or hL-SIGN. Our results provide evidence that hDC- and hL-SIGN can mediate the entry of Junín virus into cells, and may play an important role in virus infection and dissemination in the host. © 2013 Elsevier Inc. Fil:Martinez, M.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cordo, S.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Candurra, N.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v441_n3_p612_Martinez http://hdl.handle.net/20.500.12110/paper_0006291X_v441_n3_p612_Martinez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Junín arenavirus Lectin Virus entry Virus receptor CD209 antigen lectin membrane protein protein l sign unclassified drug article cell surface comparative study controlled study host cell human internalization Junin virus Murine leukemia virus nonhuman priority journal Vesicular stomatitis virus virus culture virus entry virus envelope virus infection virus infectivity virus particle Arenavirus Junin virus Junín arenavirus Lectin Virus entry Virus receptor 3T3 Cells Animals Antigens, CD Cell Adhesion Molecules Cercopithecus aethiops Hemorrhagic Fever, American Host-Pathogen Interactions Humans Junin virus Lectins, C-Type Membrane Glycoproteins Mice Receptors, Cell Surface Receptors, Transferrin Vero Cells Viral Envelope Proteins Virus Internalization
spellingShingle	Junín arenavirus Lectin Virus entry Virus receptor CD209 antigen lectin membrane protein protein l sign unclassified drug article cell surface comparative study controlled study host cell human internalization Junin virus Murine leukemia virus nonhuman priority journal Vesicular stomatitis virus virus culture virus entry virus envelope virus infection virus infectivity virus particle Arenavirus Junin virus Junín arenavirus Lectin Virus entry Virus receptor 3T3 Cells Animals Antigens, CD Cell Adhesion Molecules Cercopithecus aethiops Hemorrhagic Fever, American Host-Pathogen Interactions Humans Junin virus Lectins, C-Type Membrane Glycoproteins Mice Receptors, Cell Surface Receptors, Transferrin Vero Cells Viral Envelope Proteins Virus Internalization Martínez, María Guadalupe Cordo, Sandra M. Candurra, Nélida Alicia Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus
topic_facet	Junín arenavirus Lectin Virus entry Virus receptor CD209 antigen lectin membrane protein protein l sign unclassified drug article cell surface comparative study controlled study host cell human internalization Junin virus Murine leukemia virus nonhuman priority journal Vesicular stomatitis virus virus culture virus entry virus envelope virus infection virus infectivity virus particle Arenavirus Junin virus Junín arenavirus Lectin Virus entry Virus receptor 3T3 Cells Animals Antigens, CD Cell Adhesion Molecules Cercopithecus aethiops Hemorrhagic Fever, American Host-Pathogen Interactions Humans Junin virus Lectins, C-Type Membrane Glycoproteins Mice Receptors, Cell Surface Receptors, Transferrin Vero Cells Viral Envelope Proteins Virus Internalization
description	The target cell tropism of enveloped viruses is regulated by interactions between viral proteins and cellular receptors determining susceptibility at a host cell, tissue or species level. However, a number of additional cell-surface moieties can also bind viral envelope glycoproteins and could act as capture receptors, serving as attachment factors to concentrate virus particles on the cell surface, or to disseminate the virus infection to target organs or susceptible cells within the host. Here, we used Junín virus (JUNV) or JUNV glycoprotein complex (GPC)-pseudotyped particles to study their ability to be internalized by the human C-type lectins hDC- or hL-SIGN. Our results provide evidence that hDC- and hL-SIGN can mediate the entry of Junín virus into cells, and may play an important role in virus infection and dissemination in the host. © 2013 Elsevier Inc.
author	Martínez, María Guadalupe Cordo, Sandra M. Candurra, Nélida Alicia
author_facet	Martínez, María Guadalupe Cordo, Sandra M. Candurra, Nélida Alicia
author_sort	Martínez, María Guadalupe
title	Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus
title_short	Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus
title_full	Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus
title_fullStr	Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus
title_full_unstemmed	Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus
title_sort	utilization of human dc-sign and l-sign for entry and infection of host cells by the new world arenavirus, junín virus
publishDate	2013
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v441_n3_p612_Martinez http://hdl.handle.net/20.500.12110/paper_0006291X_v441_n3_p612_Martinez
work_keys_str_mv	AT martinezmariaguadalupe utilizationofhumandcsignandlsignforentryandinfectionofhostcellsbythenewworldarenavirusjuninvirus AT cordosandram utilizationofhumandcsignandlsignforentryandinfectionofhostcellsbythenewworldarenavirusjuninvirus AT candurranelidaalicia utilizationofhumandcsignandlsignforentryandinfectionofhostcellsbythenewworldarenavirusjuninvirus
_version_	1768544347054145536

Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus

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