STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line

Gene regulation mediated by STAT factors has been implicated in cellular functions with relevance to a variety of processes. Particularly, STAT5 and STAT3 play a crucial role in mammary epithelium displaying reciprocal activation kinetics during pregnancy, lactation and involution. Here, we show tha...

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Detalles Bibliográficos
Autores principales: Rodríguez Granillo, Agustina, Boffi, Juan Carlos, Barañao, José Lino S., Kordon, Edith Claudia, Pecci, Adali, Guberman, Alejandra Sonia
Publicado: 2007
Materias:
Gene expression
HC11
Involution
LIF
Mammary epithelium
Prolactin
Signal transduction
STAT3
STAT5
leukemia inhibitory factor
prolactin
STAT3 protein
STAT5 protein
article
breast epithelium
controlled study
gene control
gene expression regulation
gene repression
human
human cell
involution
priority journal
promoter region
protein phosphorylation
signal transduction
transcription regulation
Animals
bcl-X Protein
CCAAT-Enhancer-Binding Protein-delta
Dexamethasone
Epithelium
Insulin
Leukemia Inhibitory Factor
Mammary Glands, Animal
Mice
Phosphorylation
Promoter Regions (Genetics)
Proto-Oncogene Proteins c-fos
STAT3 Transcription Factor
STAT5 Transcription Factor
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v356_n3_p727_RodriguezGranillo
http://hdl.handle.net/20.500.12110/paper_0006291X_v356_n3_p727_RodriguezGranillo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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