13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7

The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of n...

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Autores principales: Resnicoff, Mariana, Lauinger de Medrano, Estela E.
Publicado: 1987
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Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v143_n1_p309_Resnicoff
http://hdl.handle.net/20.500.12110/paper_0006291X_v143_n1_p309_Resnicoff
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spelling paper:paper_0006291X_v143_n1_p309_Resnicoff2023-06-08T14:30:04Z 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 Resnicoff, Mariana Lauinger de Medrano, Estela E. growth factor 13 cis retinal breast breast tumor cell strain mcf 7 dose response drug mechanism drug response growth stimulation human human cell pharmacokinetics priority journal protein synthesis Breast Neoplasms Cell Division Cell Line Cell Nucleus Female Human Kinetics Neoplasm Proteins Nucleoproteins Retinaldehyde Retinoids Support, Non-U.S. Gov't The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of nuclear proteins in cronically treated cells. The cytoplasmic proteins and proteins released to the culture medium are transiently and oppositly modified. Moreover, cronic treated cells have growth advantages over the untreated counterparts in a clonogenic soft agar assay. © 1987. Fil:Resnicoff, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Medrano, E.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1987 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v143_n1_p309_Resnicoff http://hdl.handle.net/20.500.12110/paper_0006291X_v143_n1_p309_Resnicoff
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic growth factor
13 cis retinal
breast
breast tumor
cell strain mcf 7
dose response
drug mechanism
drug response
growth stimulation
human
human cell
pharmacokinetics
priority journal
protein synthesis
Breast Neoplasms
Cell Division
Cell Line
Cell Nucleus
Female
Human
Kinetics
Neoplasm Proteins
Nucleoproteins
Retinaldehyde
Retinoids
Support, Non-U.S. Gov't
spellingShingle growth factor
13 cis retinal
breast
breast tumor
cell strain mcf 7
dose response
drug mechanism
drug response
growth stimulation
human
human cell
pharmacokinetics
priority journal
protein synthesis
Breast Neoplasms
Cell Division
Cell Line
Cell Nucleus
Female
Human
Kinetics
Neoplasm Proteins
Nucleoproteins
Retinaldehyde
Retinoids
Support, Non-U.S. Gov't
Resnicoff, Mariana
Lauinger de Medrano, Estela E.
13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7
topic_facet growth factor
13 cis retinal
breast
breast tumor
cell strain mcf 7
dose response
drug mechanism
drug response
growth stimulation
human
human cell
pharmacokinetics
priority journal
protein synthesis
Breast Neoplasms
Cell Division
Cell Line
Cell Nucleus
Female
Human
Kinetics
Neoplasm Proteins
Nucleoproteins
Retinaldehyde
Retinoids
Support, Non-U.S. Gov't
description The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of nuclear proteins in cronically treated cells. The cytoplasmic proteins and proteins released to the culture medium are transiently and oppositly modified. Moreover, cronic treated cells have growth advantages over the untreated counterparts in a clonogenic soft agar assay. © 1987.
author Resnicoff, Mariana
Lauinger de Medrano, Estela E.
author_facet Resnicoff, Mariana
Lauinger de Medrano, Estela E.
author_sort Resnicoff, Mariana
title 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7
title_short 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7
title_full 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7
title_fullStr 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7
title_full_unstemmed 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7
title_sort 13-cis-retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells mcf-7
publishDate 1987
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v143_n1_p309_Resnicoff
http://hdl.handle.net/20.500.12110/paper_0006291X_v143_n1_p309_Resnicoff
work_keys_str_mv AT resnicoffmariana 13cisretinalstimulatesproliferationandinducesintranuclearproteinaccumulationinthehumanmammarytumorcellsmcf7
AT lauingerdemedranoestelae 13cisretinalstimulatesproliferationandinducesintranuclearproteinaccumulationinthehumanmammarytumorcellsmcf7
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