13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7
The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of n...
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1987
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v143_n1_p309_Resnicoff http://hdl.handle.net/20.500.12110/paper_0006291X_v143_n1_p309_Resnicoff |
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paper:paper_0006291X_v143_n1_p309_Resnicoff2023-06-08T14:30:04Z 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 Resnicoff, Mariana Lauinger de Medrano, Estela E. growth factor 13 cis retinal breast breast tumor cell strain mcf 7 dose response drug mechanism drug response growth stimulation human human cell pharmacokinetics priority journal protein synthesis Breast Neoplasms Cell Division Cell Line Cell Nucleus Female Human Kinetics Neoplasm Proteins Nucleoproteins Retinaldehyde Retinoids Support, Non-U.S. Gov't The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of nuclear proteins in cronically treated cells. The cytoplasmic proteins and proteins released to the culture medium are transiently and oppositly modified. Moreover, cronic treated cells have growth advantages over the untreated counterparts in a clonogenic soft agar assay. © 1987. Fil:Resnicoff, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Medrano, E.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1987 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v143_n1_p309_Resnicoff http://hdl.handle.net/20.500.12110/paper_0006291X_v143_n1_p309_Resnicoff |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
growth factor 13 cis retinal breast breast tumor cell strain mcf 7 dose response drug mechanism drug response growth stimulation human human cell pharmacokinetics priority journal protein synthesis Breast Neoplasms Cell Division Cell Line Cell Nucleus Female Human Kinetics Neoplasm Proteins Nucleoproteins Retinaldehyde Retinoids Support, Non-U.S. Gov't |
spellingShingle |
growth factor 13 cis retinal breast breast tumor cell strain mcf 7 dose response drug mechanism drug response growth stimulation human human cell pharmacokinetics priority journal protein synthesis Breast Neoplasms Cell Division Cell Line Cell Nucleus Female Human Kinetics Neoplasm Proteins Nucleoproteins Retinaldehyde Retinoids Support, Non-U.S. Gov't Resnicoff, Mariana Lauinger de Medrano, Estela E. 13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
topic_facet |
growth factor 13 cis retinal breast breast tumor cell strain mcf 7 dose response drug mechanism drug response growth stimulation human human cell pharmacokinetics priority journal protein synthesis Breast Neoplasms Cell Division Cell Line Cell Nucleus Female Human Kinetics Neoplasm Proteins Nucleoproteins Retinaldehyde Retinoids Support, Non-U.S. Gov't |
description |
The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low dosis (10-8 - 10-7 M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of nuclear proteins in cronically treated cells. The cytoplasmic proteins and proteins released to the culture medium are transiently and oppositly modified. Moreover, cronic treated cells have growth advantages over the untreated counterparts in a clonogenic soft agar assay. © 1987. |
author |
Resnicoff, Mariana Lauinger de Medrano, Estela E. |
author_facet |
Resnicoff, Mariana Lauinger de Medrano, Estela E. |
author_sort |
Resnicoff, Mariana |
title |
13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
title_short |
13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
title_full |
13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
title_fullStr |
13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
title_full_unstemmed |
13-cis-Retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7 |
title_sort |
13-cis-retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells mcf-7 |
publishDate |
1987 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v143_n1_p309_Resnicoff http://hdl.handle.net/20.500.12110/paper_0006291X_v143_n1_p309_Resnicoff |
work_keys_str_mv |
AT resnicoffmariana 13cisretinalstimulatesproliferationandinducesintranuclearproteinaccumulationinthehumanmammarytumorcellsmcf7 AT lauingerdemedranoestelae 13cisretinalstimulatesproliferationandinducesintranuclearproteinaccumulationinthehumanmammarytumorcellsmcf7 |
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1768542965670608896 |