Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms
The epididymal portion of the rat vas deferens from normal and castrated rats exhibited clear differences regarding both the threshold and the maximal response to acetylcholine. Alpha adrenoceptor antagonists, hexamethonium and 6-hydroxydopamine diminished the effectiveness of low acetylcholine conc...
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1981
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00039780_v250_n2_p212_DelAgostini http://hdl.handle.net/20.500.12110/paper_00039780_v250_n2_p212_DelAgostini |
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paper:paper_00039780_v250_n2_p212_DelAgostini |
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paper:paper_00039780_v250_n2_p212_DelAgostini2023-06-08T14:24:50Z Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms acetylcholine desipramine hexamethonium oxidopamine phenoxybenzamine phentolamine animal experiment castration controlled study drug response male genital system rat smooth muscle contractility vas deferens Acetylcholine Adrenergic alpha-Antagonists Animal Castration Comparative Study In Vitro Male Muscle Contraction Norepinephrine Rats Receptors, Adrenergic Support, Non-U.S. Gov't Testis Vas Deferens The epididymal portion of the rat vas deferens from normal and castrated rats exhibited clear differences regarding both the threshold and the maximal response to acetylcholine. Alpha adrenoceptor antagonists, hexamethonium and 6-hydroxydopamine diminished the effectiveness of low acetylcholine concentrations on normal and castrated preparations of the epididymal portion of isolated rat vas deferens, but did not influence the maximal response. On the other hand, desipramine enhanced the action of low concentrations of acetylcholine, both in threshold and maximal response, but failed to alter the reactivity to high concentrations of acetylcholine. The results obtained suggest that low doses of acetylcholine may affect the contractile function of the isolated epididymal portion of rat vas deferens by producing a release of norepinephrine from presynaptic sites and act in a similar fashion on preparations from both normal and castrated animals. 1981 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00039780_v250_n2_p212_DelAgostini http://hdl.handle.net/20.500.12110/paper_00039780_v250_n2_p212_DelAgostini |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
acetylcholine desipramine hexamethonium oxidopamine phenoxybenzamine phentolamine animal experiment castration controlled study drug response male genital system rat smooth muscle contractility vas deferens Acetylcholine Adrenergic alpha-Antagonists Animal Castration Comparative Study In Vitro Male Muscle Contraction Norepinephrine Rats Receptors, Adrenergic Support, Non-U.S. Gov't Testis Vas Deferens |
| spellingShingle |
acetylcholine desipramine hexamethonium oxidopamine phenoxybenzamine phentolamine animal experiment castration controlled study drug response male genital system rat smooth muscle contractility vas deferens Acetylcholine Adrenergic alpha-Antagonists Animal Castration Comparative Study In Vitro Male Muscle Contraction Norepinephrine Rats Receptors, Adrenergic Support, Non-U.S. Gov't Testis Vas Deferens Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms |
| topic_facet |
acetylcholine desipramine hexamethonium oxidopamine phenoxybenzamine phentolamine animal experiment castration controlled study drug response male genital system rat smooth muscle contractility vas deferens Acetylcholine Adrenergic alpha-Antagonists Animal Castration Comparative Study In Vitro Male Muscle Contraction Norepinephrine Rats Receptors, Adrenergic Support, Non-U.S. Gov't Testis Vas Deferens |
| description |
The epididymal portion of the rat vas deferens from normal and castrated rats exhibited clear differences regarding both the threshold and the maximal response to acetylcholine. Alpha adrenoceptor antagonists, hexamethonium and 6-hydroxydopamine diminished the effectiveness of low acetylcholine concentrations on normal and castrated preparations of the epididymal portion of isolated rat vas deferens, but did not influence the maximal response. On the other hand, desipramine enhanced the action of low concentrations of acetylcholine, both in threshold and maximal response, but failed to alter the reactivity to high concentrations of acetylcholine. The results obtained suggest that low doses of acetylcholine may affect the contractile function of the isolated epididymal portion of rat vas deferens by producing a release of norepinephrine from presynaptic sites and act in a similar fashion on preparations from both normal and castrated animals. |
| title |
Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms |
| title_short |
Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms |
| title_full |
Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms |
| title_fullStr |
Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms |
| title_full_unstemmed |
Differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. A participation of adrenergic mechanisms |
| title_sort |
differences in the effects of acetylcholine on the vas deferens from normal and castrated rats. a participation of adrenergic mechanisms |
| publishDate |
1981 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00039780_v250_n2_p212_DelAgostini http://hdl.handle.net/20.500.12110/paper_00039780_v250_n2_p212_DelAgostini |
| _version_ |
1768542106108821504 |