Nitrite reduction mediated by heme models. Routes to NO and HNO?

The water-soluble ferriheme model Fe III (TPPS) mediates oxygen atom transfer from inorganic nitrite to a water-soluble phosphine (tppts), dimethyl sulfide, and the biological thiols cysteine (CysSH) and glutathione (GSH). The products with the latter reductant are the respective sulfenic acids CysS...

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Detalles Bibliográficos
Autores principales:	Suarez, Sebastian, Doctorovich, Fabio Ariel
Publicado:	2013
Materias:	Biological thiols Dimethyl sulfide Ischemia/reperfusion Nitrite reduction Oxygen atom transfer Potential mechanism Reactive intermediate Redox transformations Amino acids Iron compounds Linear transformations Phosphorus compounds Reduction cysteine dimethyl sulfide glutathione hematin heme nitric acid nitric oxide nitrite oxygen phosphine sulfenic acid derivative thiol aqueous solution article electrochemistry ischemia nitrosylation oxidation reduction reaction reperfusion injury Hemeproteins Nitric Oxide Nitrites Nitrogen Oxides Oxidation-Reduction
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00027863_v135_n10_p4007_Heinecke http://hdl.handle.net/20.500.12110/paper_00027863_v135_n10_p4007_Heinecke
Aporte de:	Aportado por : Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires .

id	paper:paper_00027863_v135_n10_p4007_Heinecke
record_format	dspace
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Biological thiols Dimethyl sulfide Ischemia/reperfusion Nitrite reduction Oxygen atom transfer Potential mechanism Reactive intermediate Redox transformations Amino acids Iron compounds Linear transformations Phosphorus compounds Reduction cysteine dimethyl sulfide glutathione hematin heme nitric acid nitric oxide nitrite oxygen phosphine sulfenic acid derivative thiol aqueous solution article electrochemistry ischemia nitrosylation oxidation reduction reaction reperfusion injury Hemeproteins Nitric Oxide Nitrites Nitrogen Oxides Oxidation-Reduction
spellingShingle	Biological thiols Dimethyl sulfide Ischemia/reperfusion Nitrite reduction Oxygen atom transfer Potential mechanism Reactive intermediate Redox transformations Amino acids Iron compounds Linear transformations Phosphorus compounds Reduction cysteine dimethyl sulfide glutathione hematin heme nitric acid nitric oxide nitrite oxygen phosphine sulfenic acid derivative thiol aqueous solution article electrochemistry ischemia nitrosylation oxidation reduction reaction reperfusion injury Hemeproteins Nitric Oxide Nitrites Nitrogen Oxides Oxidation-Reduction Suarez, Sebastian Doctorovich, Fabio Ariel Nitrite reduction mediated by heme models. Routes to NO and HNO?
topic_facet	Biological thiols Dimethyl sulfide Ischemia/reperfusion Nitrite reduction Oxygen atom transfer Potential mechanism Reactive intermediate Redox transformations Amino acids Iron compounds Linear transformations Phosphorus compounds Reduction cysteine dimethyl sulfide glutathione hematin heme nitric acid nitric oxide nitrite oxygen phosphine sulfenic acid derivative thiol aqueous solution article electrochemistry ischemia nitrosylation oxidation reduction reaction reperfusion injury Hemeproteins Nitric Oxide Nitrites Nitrogen Oxides Oxidation-Reduction
description	The water-soluble ferriheme model Fe III (TPPS) mediates oxygen atom transfer from inorganic nitrite to a water-soluble phosphine (tppts), dimethyl sulfide, and the biological thiols cysteine (CysSH) and glutathione (GSH). The products with the latter reductant are the respective sulfenic acids CysS(O)H and GS(O)H, although these reactive intermediates are rapidly trapped by reaction with excess thiol. The nitrosyl complex Fe II (TPPS)(NO) is the dominant iron species while excess substrate is present. However, in slightly acidic media (pH ≈ 6), the system does not terminate at this very stable ferrous nitrosyl. Instead, it displays a matrix of redox transformations linking spontaneous regeneration of Fe III (TPPS) to the formation of both N 2 O and NO. Electrochemical sensor and trapping experiments demonstrate that HNO (nitroxyl) is formed, at least when tppts is the reductant. HNO is the likely predecessor of the N 2 O. A key pathway to NO formation is nitrite reduction by Fe II (TPPS), and the kinetics of this iron-mediated transformation are described. Given that inorganic nitrite has protective roles during ischemia/reperfusion (I/R) injury to organs, attributed in part to NO formation, and that HNO may also reduce net damage from I/R, the present studies are relevant to potential mechanisms of such nitrite protection. © 2013 American Chemical Society.
author	Suarez, Sebastian Doctorovich, Fabio Ariel
author_facet	Suarez, Sebastian Doctorovich, Fabio Ariel
author_sort	Suarez, Sebastian
title	Nitrite reduction mediated by heme models. Routes to NO and HNO?
title_short	Nitrite reduction mediated by heme models. Routes to NO and HNO?
title_full	Nitrite reduction mediated by heme models. Routes to NO and HNO?
title_fullStr	Nitrite reduction mediated by heme models. Routes to NO and HNO?
title_full_unstemmed	Nitrite reduction mediated by heme models. Routes to NO and HNO?
title_sort	nitrite reduction mediated by heme models. routes to no and hno?
publishDate	2013
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00027863_v135_n10_p4007_Heinecke http://hdl.handle.net/20.500.12110/paper_00027863_v135_n10_p4007_Heinecke
work_keys_str_mv	AT suarezsebastian nitritereductionmediatedbyhememodelsroutestonoandhno AT doctorovichfabioariel nitritereductionmediatedbyhememodelsroutestonoandhno
bdutipo_str	Repositorios
_version_	1764820555506122755

Nitrite reduction mediated by heme models. Routes to NO and HNO?

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