Fast Nitroxyl Trapping by Ferric Porphyrins

Iron(II) porphyrin nitrosyl complexes are obtained in high yields from the reaction of iron(III) porphyrins with the nitroxyl donors sodium trioxodinitrate and toluensulfohydroxamic acid. The reaction was found to proceed both in organic solvents and in aqueous media from iron(III) (meso-tetraphenyl...

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Autores principales:	Bari, Sara Elizabeth, Martí, Marcelo Adrián, Estrin, Dario Ariel, Doctorovich, Fabio Ariel
Publicado:	2003
Materias:	anion ferric porphyrin derivative heme derivative hydroxamic acid derivative nitric acid derivative nitric oxide nitric oxide synthase nitroxyl derivative porphyrin derivative protoporphyrin protoporphyrin iron sodium trioxodinitrate toluenesulfohydroxamic acid unclassified drug acidity alkalinity aqueous solution article chemical model chemical reaction decomposition dimerization electron transport pH Raman spectrometry reaction analysis reduction reductive nitrosylation synthesis technique ultraviolet spectroscopy Ferric Compounds Free Radicals Hydrogen-Ion Concentration Kinetics Metalloporphyrins Nitrogen Oxides Spectrophotometry, Ultraviolet
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00027863_v125_n50_p15272_Bari http://hdl.handle.net/20.500.12110/paper_00027863_v125_n50_p15272_Bari
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00027863_v125_n50_p15272_Bari
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spelling	paper:paper_00027863_v125_n50_p15272_Bari2023-06-08T14:22:39Z Fast Nitroxyl Trapping by Ferric Porphyrins Bari, Sara Elizabeth Martí, Marcelo Adrián Estrin, Dario Ariel Doctorovich, Fabio Ariel anion ferric porphyrin derivative heme derivative hydroxamic acid derivative nitric acid derivative nitric oxide nitric oxide synthase nitroxyl derivative porphyrin derivative protoporphyrin protoporphyrin iron sodium trioxodinitrate toluenesulfohydroxamic acid unclassified drug acidity alkalinity aqueous solution article chemical model chemical reaction decomposition dimerization electron transport pH Raman spectrometry reaction analysis reduction reductive nitrosylation synthesis technique ultraviolet spectroscopy Ferric Compounds Free Radicals Hydrogen-Ion Concentration Kinetics Metalloporphyrins Nitrogen Oxides Spectrophotometry, Ultraviolet Iron(II) porphyrin nitrosyl complexes are obtained in high yields from the reaction of iron(III) porphyrins with the nitroxyl donors sodium trioxodinitrate and toluensulfohydroxamic acid. The reaction was found to proceed both in organic solvents and in aqueous media from iron(III) (meso-tetraphenyl) porphyrinate ([FeIII(TPP)]+) and iron(III) meso-tetrakis (4-sulfonatophenyl) porphyrinate ([FeIII(TPPS)]3-) or iron(III) protoporphyrin IX, respectively. The kinetic rate constant for the reaction of ([FeIII(TPPS)]3-) with sodium trioxodinitrate (kon) was estimated to be 1.00 ± 0.04 × 107 M-1 s-1. As well as resulting in a versatile method for obtaining ferrous nitrosyl porphyrins, the reaction points at ferric porphyrins as efficient nitroxyl traps and provides a tool to model nitroxyl reactivity toward hemeproteins. Copyright © 2003 American Chemical Society. Fil:Bari, S.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Martí, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Estrin, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Doctorovich, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2003 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00027863_v125_n50_p15272_Bari http://hdl.handle.net/20.500.12110/paper_00027863_v125_n50_p15272_Bari
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	anion ferric porphyrin derivative heme derivative hydroxamic acid derivative nitric acid derivative nitric oxide nitric oxide synthase nitroxyl derivative porphyrin derivative protoporphyrin protoporphyrin iron sodium trioxodinitrate toluenesulfohydroxamic acid unclassified drug acidity alkalinity aqueous solution article chemical model chemical reaction decomposition dimerization electron transport pH Raman spectrometry reaction analysis reduction reductive nitrosylation synthesis technique ultraviolet spectroscopy Ferric Compounds Free Radicals Hydrogen-Ion Concentration Kinetics Metalloporphyrins Nitrogen Oxides Spectrophotometry, Ultraviolet
spellingShingle	anion ferric porphyrin derivative heme derivative hydroxamic acid derivative nitric acid derivative nitric oxide nitric oxide synthase nitroxyl derivative porphyrin derivative protoporphyrin protoporphyrin iron sodium trioxodinitrate toluenesulfohydroxamic acid unclassified drug acidity alkalinity aqueous solution article chemical model chemical reaction decomposition dimerization electron transport pH Raman spectrometry reaction analysis reduction reductive nitrosylation synthesis technique ultraviolet spectroscopy Ferric Compounds Free Radicals Hydrogen-Ion Concentration Kinetics Metalloporphyrins Nitrogen Oxides Spectrophotometry, Ultraviolet Bari, Sara Elizabeth Martí, Marcelo Adrián Estrin, Dario Ariel Doctorovich, Fabio Ariel Fast Nitroxyl Trapping by Ferric Porphyrins
topic_facet	anion ferric porphyrin derivative heme derivative hydroxamic acid derivative nitric acid derivative nitric oxide nitric oxide synthase nitroxyl derivative porphyrin derivative protoporphyrin protoporphyrin iron sodium trioxodinitrate toluenesulfohydroxamic acid unclassified drug acidity alkalinity aqueous solution article chemical model chemical reaction decomposition dimerization electron transport pH Raman spectrometry reaction analysis reduction reductive nitrosylation synthesis technique ultraviolet spectroscopy Ferric Compounds Free Radicals Hydrogen-Ion Concentration Kinetics Metalloporphyrins Nitrogen Oxides Spectrophotometry, Ultraviolet
description	Iron(II) porphyrin nitrosyl complexes are obtained in high yields from the reaction of iron(III) porphyrins with the nitroxyl donors sodium trioxodinitrate and toluensulfohydroxamic acid. The reaction was found to proceed both in organic solvents and in aqueous media from iron(III) (meso-tetraphenyl) porphyrinate ([FeIII(TPP)]+) and iron(III) meso-tetrakis (4-sulfonatophenyl) porphyrinate ([FeIII(TPPS)]3-) or iron(III) protoporphyrin IX, respectively. The kinetic rate constant for the reaction of ([FeIII(TPPS)]3-) with sodium trioxodinitrate (kon) was estimated to be 1.00 ± 0.04 × 107 M-1 s-1. As well as resulting in a versatile method for obtaining ferrous nitrosyl porphyrins, the reaction points at ferric porphyrins as efficient nitroxyl traps and provides a tool to model nitroxyl reactivity toward hemeproteins. Copyright © 2003 American Chemical Society.
author	Bari, Sara Elizabeth Martí, Marcelo Adrián Estrin, Dario Ariel Doctorovich, Fabio Ariel
author_facet	Bari, Sara Elizabeth Martí, Marcelo Adrián Estrin, Dario Ariel Doctorovich, Fabio Ariel
author_sort	Bari, Sara Elizabeth
title	Fast Nitroxyl Trapping by Ferric Porphyrins
title_short	Fast Nitroxyl Trapping by Ferric Porphyrins
title_full	Fast Nitroxyl Trapping by Ferric Porphyrins
title_fullStr	Fast Nitroxyl Trapping by Ferric Porphyrins
title_full_unstemmed	Fast Nitroxyl Trapping by Ferric Porphyrins
title_sort	fast nitroxyl trapping by ferric porphyrins
publishDate	2003
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00027863_v125_n50_p15272_Bari http://hdl.handle.net/20.500.12110/paper_00027863_v125_n50_p15272_Bari
work_keys_str_mv	AT barisaraelizabeth fastnitroxyltrappingbyferricporphyrins AT martimarceloadrian fastnitroxyltrappingbyferricporphyrins AT estrindarioariel fastnitroxyltrappingbyferricporphyrins AT doctorovichfabioariel fastnitroxyltrappingbyferricporphyrins
_version_	1768543159148609536

Fast Nitroxyl Trapping by Ferric Porphyrins

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