Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process

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Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do...

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Autores principales: Forcato, Cecilia, Bavassi, Luz, De Pino, Gabriela, Fernández, Rodrigo Sebastián, Villarreal, Mirta Fabiana, Pedreira, María Eugenia
Formato: Artículo
Lenguaje:en_US
Publicado: PLOS ONE 2016
Acceso en línea:http://localhost:8080/xmlui/handle/1/49
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Repositorio Institucional Digital (RID ISALUD) de Universidad ISALUD
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spelling I92-R382-1-492016-12-31T00:27:34Z Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process Forcato, Cecilia Bavassi, Luz De Pino, Gabriela Fernández, Rodrigo Sebastián Villarreal, Mirta Fabiana Pedreira, María Eugenia Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do not. We hypothesize that the different effects observed by the different reminder types on memory labilization-reconsolidation depend on a differential neural involvement during reminder presentation. To test it, we developed a declarative task and compared the efficacy of three reminder types in triggering the process in humans (Experiment 1). Finally, we compared the brain activation patterns between the different conditions using functional magnetic resonance imaging (fMRI) (Experiment 2). We confirmed that the unpredictable reminder is the most effective in initiating the labilization-reconsolidation process. Furthermore, only under this condition there was differential left hippocampal activation during its presentation. We suggest that the left hippocampus is detecting the incongruence between actual and past events and allows the memory to be updated. 2016-12-31T00:27:34Z 2016-12-31T00:27:34Z 2016 Article Forcato C, Bavassi L, De Pino G, Fernández RS, Villarreal MF, Pedreira ME Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process. PLoS ONE. 2016 11(3): e0151381 1888-5555 http://localhost:8080/xmlui/handle/1/49 en_US PLOS ONE
institution Universidad ISALUD
institution_str I-92
repository_str R-382
collection Repositorio Institucional Digital (RID ISALUD)
language en_US
description Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do not. We hypothesize that the different effects observed by the different reminder types on memory labilization-reconsolidation depend on a differential neural involvement during reminder presentation. To test it, we developed a declarative task and compared the efficacy of three reminder types in triggering the process in humans (Experiment 1). Finally, we compared the brain activation patterns between the different conditions using functional magnetic resonance imaging (fMRI) (Experiment 2). We confirmed that the unpredictable reminder is the most effective in initiating the labilization-reconsolidation process. Furthermore, only under this condition there was differential left hippocampal activation during its presentation. We suggest that the left hippocampus is detecting the incongruence between actual and past events and allows the memory to be updated.
format Article
author Forcato, Cecilia
Bavassi, Luz
De Pino, Gabriela
Fernández, Rodrigo Sebastián
Villarreal, Mirta Fabiana
Pedreira, María Eugenia
spellingShingle Forcato, Cecilia
Bavassi, Luz
De Pino, Gabriela
Fernández, Rodrigo Sebastián
Villarreal, Mirta Fabiana
Pedreira, María Eugenia
Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process
author_facet Forcato, Cecilia
Bavassi, Luz
De Pino, Gabriela
Fernández, Rodrigo Sebastián
Villarreal, Mirta Fabiana
Pedreira, María Eugenia
author_sort Forcato, Cecilia
title Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process
title_short Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process
title_full Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process
title_fullStr Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process
title_full_unstemmed Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process
title_sort differential left hippocampal activation during retrieval with different types of reminders: an fmri study of the reconsolidation process
publisher PLOS ONE
publishDate 2016
url http://localhost:8080/xmlui/handle/1/49
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