Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina

Fil: Badano, Inés. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina.

Detalles Bibliográficos
Autores principales: Badano, Inés, Sanabria, Daiana Jimena, Tótaro, Roxana María, Rubinstein, Samara, Gili, Juan Antonio, Liotta, Domingo Javier, Picconi, María Alejandra, Campos, Rodolfo Héctor, Schurr, Theodore G.
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: Public Library of Science 2018
Materias:
HPV infection
Mitochondrial dna ancestry
Cervical cáncer
Posadas Misiones Argentina
Acceso en línea:https://hdl.handle.net/20.500.12219/4336
Aporte de:
Repositorio Institucional Digital de la UNaM (RIDUNAM) de Universidad Nacional de Misiones
id I77-R195-20.500.12219-4336
record_format dspace
institution Universidad Nacional de Misiones
institution_str I-77
repository_str R-195
collection Repositorio Institucional Digital de la UNaM (RIDUNAM)
language Inglés
topic HPV infection
Mitochondrial dna ancestry
Cervical cáncer
Posadas Misiones Argentina
spellingShingle HPV infection
Mitochondrial dna ancestry
Cervical cáncer
Posadas Misiones Argentina
Badano, Inés
Sanabria, Daiana Jimena
Tótaro, Roxana María
Rubinstein, Samara
Gili, Juan Antonio
Liotta, Domingo Javier
Picconi, María Alejandra
Campos, Rodolfo Héctor
Schurr, Theodore G.
Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina
topic_facet HPV infection
Mitochondrial dna ancestry
Cervical cáncer
Posadas Misiones Argentina
description Fil: Badano, Inés. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina.
format Artículo
Artículo
publishedVersion
author Badano, Inés
Sanabria, Daiana Jimena
Tótaro, Roxana María
Rubinstein, Samara
Gili, Juan Antonio
Liotta, Domingo Javier
Picconi, María Alejandra
Campos, Rodolfo Héctor
Schurr, Theodore G.
author_facet Badano, Inés
Sanabria, Daiana Jimena
Tótaro, Roxana María
Rubinstein, Samara
Gili, Juan Antonio
Liotta, Domingo Javier
Picconi, María Alejandra
Campos, Rodolfo Héctor
Schurr, Theodore G.
author_sort Badano, Inés
title Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina
title_short Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina
title_full Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina
title_fullStr Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina
title_full_unstemmed Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina
title_sort mitochondrial dna ancestry, hpv infection and the risk of cervical cancer in a multiethnic population of northeastern argentina
publisher Public Library of Science
publishDate 2018
url https://hdl.handle.net/20.500.12219/4336
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spelling I77-R195-20.500.12219-43362024-06-04T10:11:21Z Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina Badano, Inés Sanabria, Daiana Jimena Tótaro, Roxana María Rubinstein, Samara Gili, Juan Antonio Liotta, Domingo Javier Picconi, María Alejandra Campos, Rodolfo Héctor Schurr, Theodore G. HPV infection Mitochondrial dna ancestry Cervical cáncer Posadas Misiones Argentina Fil: Badano, Inés. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina. Fil: Badano, Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico (Nordeste); Argentina. Fil: Sanabria, Daiana Jimena. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina. Fil: Sanabria, Daiana Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico (Nordeste); Argentina. Fil: Tótaro, Roxana María. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina. Fil: Rubinstein, Samara. Universidad de Pennsylvania. Departamento de Antropología; Estados Unidos. Fil: Gili, Juan Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". Dirección de Investigación. Laboratorio de Epidemiología Genética; Argentina. Fil: Liotta, Domingo Javier. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina. Fil: Picconi, María Alejandra. Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán”. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología. Servicio de Virus Oncogénicos; Argentina. Fil: Campos, Rodolfo Héctor. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Fil: Schurr, Theodore G. Universidad de Pennsylvania. Departamento de Antropología; Estados Unidos. Background Misiones Province in northeastern Argentina is considered to be a region with a high prevalence of HPV infection and a high mortality rate due to cervical cancer. The reasons for this epidemiological trend are not completely understood. To gain insight into this problem, we explored the relationship between mitochondrial DNA (mtDNA) ancestry, HPV infection, and development of cervical lesions/cancer in women from the city of Posadas in Misiones Province. Methods Two hundred and sixty-one women, including 92 cases of patients diagnosed with cervical lesions and 169 controls, were analyzed. mtDNA ancestry was assessed through HVS1 sequencing, while the detection and typing of HPV infection was conducted through nested multiplex PCR analysis. Multivariate logistic regression was conducted with the resulting data to estimate the odds ratios (ORs) adjusted by socio-demographic variables. Results The study participants showed 68.6% Amerindian, 26.1% European and 5.3% African mtDNA ancestry, respectively. Multiple regression analysis showed that women with African mtDNAs were three times more likely to develop a cervical lesion than those with Native American or European mtDNAs [OR of 3.8 (1.2–11.5) for ancestry and OR of 3.5 (1.0–12.0) for L haplogroups], although the associated p values were not significant when tested under more complex multivariate models. HPV infection and the development of cervical lesions/cancer were significant for all tested models, with the highest OR values for HPV16 [OR of 24.2 (9.3–62.7)] and HPV-58 [OR of 19.0 (2.4–147.7)]. Conclusion HPV infection remains a central risk factor for cervical cancer in the Posadas population. The potential role of African mtDNA ancestry opens a new avenue for future medical association studies in multiethnic populations, and will require further confirmation in large-scale studies. 2018-01-12 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion https://hdl.handle.net/20.500.12219/4336 eng info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190966 info:eu-repo/semantics/openAccess application/pdf application/pdf 1.946 MB Public Library of Science

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