Incorporation and drug delivery of sodium indomethacin into nanoclays

Layered double hydroxides (LDH) nanoclays have many applications as matrices in pharmaceutical fields as support for controlled release systems of drugs, vitamins, biomolecules, etc. γ-Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain involved in osteoarthritis, rheum...

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Autores principales: Mendieta, Silvia Nazaret, Gerbaldo, María Verónica, Pérez, Celso, Longhi, Marcela, Granero, Gladys Ester, Crivello, Mónica Elsie
Formato: Documento de conferencia draft
Lenguaje:Español
Publicado: 2022
Materias:
nanoclay
sodium indomethacin
drug delivery
Acceso en línea:http://hdl.handle.net/20.500.12272/6548
Aporte de:
RIA - Repositorio Institucional Abierto (UTN) de Universidad Tecnológica Nacional
id I68-R174-20.500.12272-6548
record_format dspace
institution Universidad Tecnológica Nacional
institution_str I-68
repository_str R-174
collection RIA - Repositorio Institucional Abierto (UTN)
language Español
topic nanoclay
sodium indomethacin
drug delivery
spellingShingle nanoclay
sodium indomethacin
drug delivery
Mendieta, Silvia Nazaret
Gerbaldo, María Verónica
Pérez, Celso
Longhi, Marcela
Granero, Gladys Ester
Crivello, Mónica Elsie
Incorporation and drug delivery of sodium indomethacin into nanoclays
topic_facet nanoclay
sodium indomethacin
drug delivery
description Layered double hydroxides (LDH) nanoclays have many applications as matrices in pharmaceutical fields as support for controlled release systems of drugs, vitamins, biomolecules, etc. γ-Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain involved in osteoarthritis, rheumatoid arthritis, bursitis, gout, etc. This work reported studies of intercalation and release of nanoclay MgAl LDH-type material containing the anionic form of indomethacin in the interlayer region, starting from sodium indomethacin (IndoNa). Sodium Indomethacin hydrate was obtained by co-precipitation of Na2CO3 and the polymorph of indomethacin was observed. Intercalated compound was prepared via ion exchange, with different incorporation time. The host laminar solid was prepared by coprecipitation of Mg-Al salts at pH 10±0.2; on N2 atmosphere, and different aging time. By X-ray diffraction was observed the drug incorporation into nanoclay. The basal spacing obtained suggests that the drugs molecules are arranged in partially interdigitated bilayers and multiple arrangements were observed. The amount of intercalated IndoNa was determined by UV-visible spectroscopy. The host with less aging and ion exchange time presented a greater incorporation. Drug release studies were performed at 37.0±0.5 °C in dissolution media simulated, intestinal fluids at pH 7.4±0.05. The maximum release was 72 % for LDH-S, but none guest solid does not release more than 85% due to the strong interaction with the brucite layer. LHD-L has a longer aging and better layer structure resulting in reduced incorporation. This behavior determines the release time. This work provides significant in-sight into the important area of storage, transport, and delivering of anionic drug over time using MgAl-LDH as a drug delivery.
format Documento de conferencia
draft
author Mendieta, Silvia Nazaret
Gerbaldo, María Verónica
Pérez, Celso
Longhi, Marcela
Granero, Gladys Ester
Crivello, Mónica Elsie
author_facet Mendieta, Silvia Nazaret
Gerbaldo, María Verónica
Pérez, Celso
Longhi, Marcela
Granero, Gladys Ester
Crivello, Mónica Elsie
author_sort Mendieta, Silvia Nazaret
title Incorporation and drug delivery of sodium indomethacin into nanoclays
title_short Incorporation and drug delivery of sodium indomethacin into nanoclays
title_full Incorporation and drug delivery of sodium indomethacin into nanoclays
title_fullStr Incorporation and drug delivery of sodium indomethacin into nanoclays
title_full_unstemmed Incorporation and drug delivery of sodium indomethacin into nanoclays
title_sort incorporation and drug delivery of sodium indomethacin into nanoclays
publishDate 2022
url http://hdl.handle.net/20.500.12272/6548
work_keys_str_mv AT mendietasilvianazaret incorporationanddrugdeliveryofsodiumindomethacinintonanoclays
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