Synthesis and swelling behavior of pH-responsive polyurethane poly(2-(diethylamino)ethyl methacrylate) hybrid materials

Polyurethane (PU)/poly[2-(diethylamino)ethyl methacrylate] hybrids, having a chemical bond between the PU and acrylic moieties and with different compositions, were prepared by the dispersion polymerization of 2-(diethylamino)ethyl methacrylate (DEA) in the presence of preformed PU chains with polym...

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Autores principales: Pardini, Francisco, Amalvy, Javier
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2019
Materias:
drug-delivery systems; PUs; stimuli-sensitive polymers; swelling
Acceso en línea:http://hdl.handle.net/20.500.12272/3413
Aporte de:
RIA - Repositorio Institucional Abierto (UTN) de Universidad Tecnológica Nacional
id I68-R174-20.500.12272-3413
record_format dspace
institution Universidad Tecnológica Nacional
institution_str I-68
repository_str R-174
collection RIA - Repositorio Institucional Abierto (UTN)
language Inglés
topic drug-delivery systems; PUs; stimuli-sensitive polymers; swelling
spellingShingle drug-delivery systems; PUs; stimuli-sensitive polymers; swelling
Pardini, Francisco
Amalvy, Javier
Synthesis and swelling behavior of pH-responsive polyurethane poly(2-(diethylamino)ethyl methacrylate) hybrid materials
topic_facet drug-delivery systems; PUs; stimuli-sensitive polymers; swelling
description Polyurethane (PU)/poly[2-(diethylamino)ethyl methacrylate] hybrids, having a chemical bond between the PU and acrylic moieties and with different compositions, were prepared by the dispersion polymerization of 2-(diethylamino)ethyl methacrylate (DEA) in the presence of preformed PU chains with polymerizable terminal vinyl groups. The PU dispersion was synthesized accord- ing to a prepolymer mixing process by the polyaddition of isophorone diisocyanate, poly(propylene glycol), 2-hydroxyethyl methacry- late, and dimethylol propionic acid (DMPA). Then, it was dispersed in water by the prior neutralization of the carboxylic acid groups of DMPA with triethylamine, chain-extended with ethylenediamine. The effect of the DEA content on the swelling properties (water uptake and dynamic swelling degree) at different pHs and at 37�����C was determined. The samples were also characterized by Fourier transform infrared spectroscopy and modulated differential scanning calorimetry. The experimental results indicate a higher water uptake when the DEA content was increased on the hybrid materials and a significant change in the kinetics of swelling at pH 4 com- pared to those at pH 7. The water content of the hydrogels depended on the DEA content, and it was inversely proportional to the pH value. The pure PU film did not show important changes over the pH range examined in this study. The synthesized hybrids were useful as drug-delivery, pH-sensitive matrices.
format Artículo
publishedVersion
Artículo
author Pardini, Francisco
Amalvy, Javier
author_facet Pardini, Francisco
Amalvy, Javier
author_sort Pardini, Francisco
title Synthesis and swelling behavior of pH-responsive polyurethane poly(2-(diethylamino)ethyl methacrylate) hybrid materials
title_short Synthesis and swelling behavior of pH-responsive polyurethane poly(2-(diethylamino)ethyl methacrylate) hybrid materials
title_full Synthesis and swelling behavior of pH-responsive polyurethane poly(2-(diethylamino)ethyl methacrylate) hybrid materials
title_fullStr Synthesis and swelling behavior of pH-responsive polyurethane poly(2-(diethylamino)ethyl methacrylate) hybrid materials
title_full_unstemmed Synthesis and swelling behavior of pH-responsive polyurethane poly(2-(diethylamino)ethyl methacrylate) hybrid materials
title_sort synthesis and swelling behavior of ph-responsive polyurethane poly(2-(diethylamino)ethyl methacrylate) hybrid materials
publishDate 2019
url http://hdl.handle.net/20.500.12272/3413
work_keys_str_mv AT pardinifrancisco synthesisandswellingbehaviorofphresponsivepolyurethanepoly2diethylaminoethylmethacrylatehybridmaterials
AT amalvyjavier synthesisandswellingbehaviorofphresponsivepolyurethanepoly2diethylaminoethylmethacrylatehybridmaterials
bdutipo_str Repositorios
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