Polyurethane Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications

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A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film-forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity a...

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Autores principales: Echeverría, María Gabriela, Pardini, Oscar, Debandi, María Valeria, François, Nora, Daraio, Marta, Amalvy, Javier
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2019
Materias:
polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
Acceso en línea:http://hdl.handle.net/20.500.12272/3411
Aporte de:
RIA - Repositorio Institucional Abierto (UTN) de Universidad Tecnológica Nacional
id I68-R174-20.500.12272-3411
record_format dspace
institution Universidad Tecnológica Nacional
institution_str I-68
repository_str R-174
collection RIA - Repositorio Institucional Abierto (UTN)
language Inglés
topic polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
spellingShingle polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
Echeverría, María Gabriela
Pardini, Oscar
Debandi, María Valeria
François, Nora
Daraio, Marta
Amalvy, Javier
Polyurethane Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
topic_facet polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
description A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film-forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.
format Artículo
publishedVersion
Artículo
author Echeverría, María Gabriela
Pardini, Oscar
Debandi, María Valeria
François, Nora
Daraio, Marta
Amalvy, Javier
author_facet Echeverría, María Gabriela
Pardini, Oscar
Debandi, María Valeria
François, Nora
Daraio, Marta
Amalvy, Javier
author_sort Echeverría, María Gabriela
title Polyurethane Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_short Polyurethane Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_full Polyurethane Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_fullStr Polyurethane Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_full_unstemmed Polyurethane Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_sort polyurethane poly(2-(diethyl amino)ethyl methacrylate) blend for drug delivery applications
publishDate 2019
url http://hdl.handle.net/20.500.12272/3411
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AT francoisnora polyurethanepoly2diethylaminoethylmethacrylateblendfordrugdeliveryapplications
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