Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments

Smart sensitive polymers have been used to improve processes in drug delivery. In this article, we evaluate the behavior of polyurethane/N,N-diethylaminoethyl methacrylate hybrids (PU/DEA) as pH- responsive polymers potentially useful for drug delivery systems development, using Rhodamine 6G (Rh6G)...

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Autores principales: Pardini, Francisco, Faccia, Paula, Amalvy, Javier
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2019
Materias:
Polymeric hybrid materials, Polyurethanes, poly(N,N-diethylaminoethyl methacrylate), Stimuli-sensitive polymers, Drug delivery systems, Films
Acceso en línea:http://hdl.handle.net/20.500.12272/3409
Aporte de:
RIA - Repositorio Institucional Abierto (UTN) de Universidad Tecnológica Nacional
id I68-R174-20.500.12272-3409
record_format dspace
institution Universidad Tecnológica Nacional
institution_str I-68
repository_str R-174
collection RIA - Repositorio Institucional Abierto (UTN)
language Inglés
topic Polymeric hybrid materials, Polyurethanes, poly(N,N-diethylaminoethyl methacrylate), Stimuli-sensitive polymers, Drug delivery systems, Films
spellingShingle Polymeric hybrid materials, Polyurethanes, poly(N,N-diethylaminoethyl methacrylate), Stimuli-sensitive polymers, Drug delivery systems, Films
Pardini, Francisco
Faccia, Paula
Amalvy, Javier
Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
topic_facet Polymeric hybrid materials, Polyurethanes, poly(N,N-diethylaminoethyl methacrylate), Stimuli-sensitive polymers, Drug delivery systems, Films
description Smart sensitive polymers have been used to improve processes in drug delivery. In this article, we evaluate the behavior of polyurethane/N,N-diethylaminoethyl methacrylate hybrids (PU/DEA) as pH- responsive polymers potentially useful for drug delivery systems development, using Rhodamine 6G (Rh6G) as a model drug. A detailed pH responsive characterization was performed by swelling studies and scanning electron microscopy (SEM). Two drug loading methods on drug release-immersion and direct loading were evaluated. The interaction between Rh6G and the polymer matrix was studied by Fourier Transform Infrared (FTIR) spectroscopy and contact angle determination. The kinetic study of Rh6G release was performed at basic and acidic pH; the mechanism of drug delivery was analyzed using Ritger-Peppas' equation. We discuss about polymer's active sites and drug's distribution through the matrix in relation to both loading methods. Results showed a pH-responsive behavior and morphological changes when pH solution varied from 9.0 to 4.0. In the immersion loading method, results indicated a higher Rh6G molecule concentration at the surface as well as ionic interaction between the drug and polymer's carboxylic groups. Release studies confirmed the pH-sensitive hybrid systems' behavior and kinetic exponent values indicated different mechanism's transport types depending on loading method and polymer composition.
format Artículo
publishedVersion
Artículo
author Pardini, Francisco
Faccia, Paula
Amalvy, Javier
author_facet Pardini, Francisco
Faccia, Paula
Amalvy, Javier
author_sort Pardini, Francisco
title Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_short Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_full Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_fullStr Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_full_unstemmed Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_sort evaluation of ph-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
publishDate 2019
url http://hdl.handle.net/20.500.12272/3409
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AT facciapaula evaluationofphsensitivepolyurethane2diethylaminoethylmethacrylatehybridspotentiallyusefulfordrugdeliverydevelopments
AT amalvyjavier evaluationofphsensitivepolyurethane2diethylaminoethylmethacrylatehybridspotentiallyusefulfordrugdeliverydevelopments
bdutipo_str Repositorios
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