The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)

Background: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gam...

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Autores principales: Ibañez, Agustín, Cetkovich, Marcelo, Petroni, Agustín, Urquina, Hugo, Baez, Sandra, Gonzalez-Gadea, María Luz, Kamienkowski, Juan Esteban, Torralva, Teresa, Torrente, Fernando, Strejilevich, Sergio, Teitelbaum, Julia, Hurtado, Esteban, Guex, Raphael, Melloni, Margherita, Lischinsky, Alicia, Sigman, Mariano, Manes, Facundo
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2018
Materias:
Trastorno por Déficit de Atención con Hiperactividad
Toma de decisiones
Helechos
Potenciales evocados
Pruebas neuropsicológicas
Trastornos del conocimiento
Conducta impulsiva
Neuropsicología
ADHD
Decision making
Ferns
Event-related potentials
Neurophsychological testing
Cognitive impairment
Impulsivity
Neuropsychology
Acceso en línea:https://doi.org/10.1371/journal.pone.0037306
https://repositorio.utdt.edu/handle/20.500.13098/11082
Aporte de:
Repositorio Digital Universidad Torcuato Di Tella de Universidad Torcuato Di Tella
id I57-R16320.500.13098-11082
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institution Universidad Torcuato Di Tella
institution_str I-57
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collection Repositorio Digital Universidad Torcuato Di Tella
language Inglés
orig_language_str_mv eng
topic Trastorno por Déficit de Atención con Hiperactividad
Toma de decisiones
Helechos
Potenciales evocados
Pruebas neuropsicológicas
Trastornos del conocimiento
Conducta impulsiva
Neuropsicología
ADHD
Decision making
Ferns
Event-related potentials
Neurophsychological testing
Cognitive impairment
Impulsivity
Neuropsychology
spellingShingle Trastorno por Déficit de Atención con Hiperactividad
Toma de decisiones
Helechos
Potenciales evocados
Pruebas neuropsicológicas
Trastornos del conocimiento
Conducta impulsiva
Neuropsicología
ADHD
Decision making
Ferns
Event-related potentials
Neurophsychological testing
Cognitive impairment
Impulsivity
Neuropsychology
Ibañez, Agustín
Cetkovich, Marcelo
Petroni, Agustín
Urquina, Hugo
Baez, Sandra
Gonzalez-Gadea, María Luz
Kamienkowski, Juan Esteban
Torralva, Teresa
Torrente, Fernando
Strejilevich, Sergio
Teitelbaum, Julia
Hurtado, Esteban
Guex, Raphael
Melloni, Margherita
Lischinsky, Alicia
Sigman, Mariano
Manes, Facundo
The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)
description Background: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD. Methodology/Principal Findings: We used the Iowa gambling task (IGT), a task of rational decision-making under risk (RDMUR) and a rapid-decision gambling task (RDGT) which elicits behavioral measures as well as event-related potentials (ERPs: fERN and P3) in connection to the motivational impact of events. We did not observe between-group differences for decision-making under risk or ambiguity (RDMUR and IGT); however, there were significant differences for the ERP-assessed RDGT. Compared to controls, the ADHD group showed a pattern of impaired learning by feedback (fERN) and insensitivity to reward magnitude (P3). This ERP pattern (fERN and P3) was associated with impulsivity, hyperactivity, executive function and working memory. Compared to controls, the BD group showed fERN- and P3-enhanced responses to reward magnitude regardless of valence. This ERP pattern (fERN and P3) was associated with mood and inhibitory control. Consistent with the ERP findings, an analysis of source location revealed reduced responses of the cingulate cortex to the valence and magnitude of rewards in patients with ADHD and BD. Conclusions/Significance: Our data suggest that neurophysiological (ERPs) paradigms such as the RDGT are well suited to assess subclinical decision-making processes in patients with ADHD and BD as well as for linking the cingulate cortex with action monitoring systems.
format Artículo
publishedVersion
author Ibañez, Agustín
Cetkovich, Marcelo
Petroni, Agustín
Urquina, Hugo
Baez, Sandra
Gonzalez-Gadea, María Luz
Kamienkowski, Juan Esteban
Torralva, Teresa
Torrente, Fernando
Strejilevich, Sergio
Teitelbaum, Julia
Hurtado, Esteban
Guex, Raphael
Melloni, Margherita
Lischinsky, Alicia
Sigman, Mariano
Manes, Facundo
author_facet Ibañez, Agustín
Cetkovich, Marcelo
Petroni, Agustín
Urquina, Hugo
Baez, Sandra
Gonzalez-Gadea, María Luz
Kamienkowski, Juan Esteban
Torralva, Teresa
Torrente, Fernando
Strejilevich, Sergio
Teitelbaum, Julia
Hurtado, Esteban
Guex, Raphael
Melloni, Margherita
Lischinsky, Alicia
Sigman, Mariano
Manes, Facundo
author_sort Ibañez, Agustín
title The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)
title_short The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)
title_full The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)
title_fullStr The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)
title_full_unstemmed The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)
title_sort neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (adhd)
publishDate 2018
url https://doi.org/10.1371/journal.pone.0037306
https://repositorio.utdt.edu/handle/20.500.13098/11082
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