How do you feel when you can’t feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder
Depersonalization-Derealization Disorder (DD) typically manifests as a disruption of body self-awareness. Interoception 2 defined as the cognitive processing of body signals2 has been extensively considered as a key processing for body selfawareness. In consequence, the purpose of this study was t...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | Artículo publishedVersion |
| Lenguaje: | Inglés |
| Publicado: |
2018
|
| Materias: | |
| Acceso en línea: | https://doi.org/10.1371/journal.pone.0098769 https://repositorio.utdt.edu/handle/20.500.13098/11076 |
| Aporte de: |
| id |
I57-R16320.500.13098-11076 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Torcuato Di Tella |
| institution_str |
I-57 |
| repository_str |
R-163 |
| collection |
Repositorio Digital Universidad Torcuato Di Tella |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
Emociones Cognición Imagen por resonancia magnética Pruebas neuropsicológicas Atención Trastornos de ansiedad Emotions Cognition Functional magnetic resonance imaging Neurophsychological testing Natural networks Graph theory Attention Anxiety |
| spellingShingle |
Emociones Cognición Imagen por resonancia magnética Pruebas neuropsicológicas Atención Trastornos de ansiedad Emotions Cognition Functional magnetic resonance imaging Neurophsychological testing Natural networks Graph theory Attention Anxiety Sedeño, Lucas Couto, Blas Melloni, Margherita Canales-Johnson, Andrés Yoris, Adrian Baez, Sandra Esteves, Sol Velasquez, Marcela Barttfeld, Pablo Sigman, Mariano Kichic, Rafael Chialvo, Dante Manes, Facundo Bekinschtein, Tristan A. Ibáñez, Agustín How do you feel when you can’t feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder |
| description |
Depersonalization-Derealization Disorder (DD) typically manifests as a disruption of body self-awareness. Interoception 2
defined as the cognitive processing of body signals2 has been extensively considered as a key processing for body selfawareness.
In consequence, the purpose of this study was to investigate whether there are systematic differences in
interoception between a patient with DD and controls that might explain the disembodiment symptoms suffered in this
disease. To assess interoception, we utilized a heartbeat detection task and measures of functional connectivity derived
from fMRI networks in interoceptive/exteroceptivo/mind-wandering states. Additionally, we evaluated empathic abilities to
test the association between interoception and emotional experience. The results showed patient’s impaired performance
in the heartbeat detection task when compared to controls. Furthermore, regarding functional connectivity, we found a
lower global brain connectivity of the patient relative to controls only in the interoceptive state. He also presented a
particular pattern of impairments in affective empathy. To our knowledge, this is the first experimental research that
assesses the relationship between interoception and DD combining behavioral and neurobiological measures. Our results
suggest that altered neural mechanisms and cognitive processes regarding body signaling might be engaged in DD
phenomenology. Moreover, our study contributes experimental data to the comprehension of brain-body interactions and
the emergence of self-awareness and emotional feelings. |
| format |
Artículo publishedVersion |
| author |
Sedeño, Lucas Couto, Blas Melloni, Margherita Canales-Johnson, Andrés Yoris, Adrian Baez, Sandra Esteves, Sol Velasquez, Marcela Barttfeld, Pablo Sigman, Mariano Kichic, Rafael Chialvo, Dante Manes, Facundo Bekinschtein, Tristan A. Ibáñez, Agustín |
| author_facet |
Sedeño, Lucas Couto, Blas Melloni, Margherita Canales-Johnson, Andrés Yoris, Adrian Baez, Sandra Esteves, Sol Velasquez, Marcela Barttfeld, Pablo Sigman, Mariano Kichic, Rafael Chialvo, Dante Manes, Facundo Bekinschtein, Tristan A. Ibáñez, Agustín |
| author_sort |
Sedeño, Lucas |
| title |
How do you feel when you can’t feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder |
| title_short |
How do you feel when you can’t feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder |
| title_full |
How do you feel when you can’t feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder |
| title_fullStr |
How do you feel when you can’t feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder |
| title_full_unstemmed |
How do you feel when you can’t feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder |
| title_sort |
how do you feel when you can’t feel your body? interoception, functional connectivity and emotional processing in depersonalization-derealization disorder |
| publishDate |
2018 |
| url |
https://doi.org/10.1371/journal.pone.0098769 https://repositorio.utdt.edu/handle/20.500.13098/11076 |
| work_keys_str_mv |
AT sedenolucas howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT coutoblas howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT mellonimargherita howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT canalesjohnsonandres howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT yorisadrian howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT baezsandra howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT estevessol howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT velasquezmarcela howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT barttfeldpablo howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT sigmanmariano howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT kichicrafael howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT chialvodante howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT manesfacundo howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT bekinschteintristana howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder AT ibanezagustin howdoyoufeelwhenyoucantfeelyourbodyinteroceptionfunctionalconnectivityandemotionalprocessingindepersonalizationderealizationdisorder |
| bdutipo_str |
Repositorios |
| _version_ |
1764820542607589378 |