In vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs.

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ARTÍCULO PUBLICADO EN REVISTA EXTERNA.Anthelmintic resistance in livestock parasites is currently a worldwide problem. Fasciola hepatica is a cosmopolitan parasite which causes considerable loss in sheep and cattle production systems all over the world. Chemotherapy is currently the main tool avail...

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Autores principales:	Solana, María Victoria, Mera y Sierra, Roberto, Scarcella, Silvana, Neira, Gisela, Solana, Hugo Daniel
Formato:	Artículo Científico
Lenguaje:	Inglés
Publicado:	Editorial Experimental Parasitology 2020
Materias:	Ovicidal activity Fasciola hepatica Closantel Egg hatch assay
Acceso en línea:	http://repositorio.umaza.edu.ar//handle/00261/1750 https://www.sciencedirect.com/science/article/abs/pii/S0014489415300576?via%3Dihub#!
Aporte de:	UMAZA Digital (Universidad MAZA - Mendoza) de Universidad Juan Agustín MAZA

id	I56-R16200261-1750
record_format	dspace
institution	Universidad Juan Agustín MAZA
institution_str	I-56
repository_str	R-162
collection	UMAZA Digital (Universidad MAZA - Mendoza)
language	Inglés
orig_language_str_mv	eng
topic	Ovicidal activity Fasciola hepatica Closantel Egg hatch assay
spellingShingle	Ovicidal activity Fasciola hepatica Closantel Egg hatch assay Solana, María Victoria Mera y Sierra, Roberto Scarcella, Silvana Neira, Gisela Solana, Hugo Daniel In vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs.
description	ARTÍCULO PUBLICADO EN REVISTA EXTERNA.Anthelmintic resistance in livestock parasites is currently a worldwide problem. Fasciola hepatica is a cosmopolitan parasite which causes considerable loss in sheep and cattle production systems all over the world. Chemotherapy is currently the main tool available for its control. The intensive use of triclabendazole, the drug of choice for more than 20 years, has resulted in the development of resistant strains. The therapeutic options are adulticides such as closantel (salicylanilide anthelmintic that binds extensively to plasma albumin) to treat chronic fascioliasis in sheep, and cattle. In the present work, an Egg Hatch Assay (EHA) and morphometric studies were used to evaluate in vivo the ovicidal activity and morphology F. hepatica eggs, recovered from closantel treated sheep collected at different time intervals post treatment. Statistically significant differences (p < 0.0001) were observed in egg morphometry between the control and the treated groups in all the parameters studied. Eggs recovered from treated animals tend to be narrower and longer. Significant differences were found in the embryonation and hatching of eggs between 36 h post treatment (32, 5%) vs. approximately 85% in control, 12 h and 24 h post treatment. Our results confirm that closantel affects in vivo the normal development of the eggs. Sitio de la revista: https://www.sciencedirect.com/science/article/abs/pii/S0014489415300576?via%3Dihub
format	Artículo Científico
author	Solana, María Victoria Mera y Sierra, Roberto Scarcella, Silvana Neira, Gisela Solana, Hugo Daniel
author_facet	Solana, María Victoria Mera y Sierra, Roberto Scarcella, Silvana Neira, Gisela Solana, Hugo Daniel
author_sort	Solana, María Victoria
title	In vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs.
title_short	In vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs.
title_full	In vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs.
title_fullStr	In vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs.
title_full_unstemmed	In vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs.
title_sort	in vivo assessment of closantel ovicidal activity in fasciola hepatica eggs.
publisher	Editorial Experimental Parasitology
publishDate	2020
url	http://repositorio.umaza.edu.ar//handle/00261/1750 https://www.sciencedirect.com/science/article/abs/pii/S0014489415300576?via%3Dihub#!
work_keys_str_mv	AT solanamariavictoria invivoassessmentofclosantelovicidalactivityinfasciolahepaticaeggs AT meraysierraroberto invivoassessmentofclosantelovicidalactivityinfasciolahepaticaeggs AT scarcellasilvana invivoassessmentofclosantelovicidalactivityinfasciolahepaticaeggs AT neiragisela invivoassessmentofclosantelovicidalactivityinfasciolahepaticaeggs AT solanahugodaniel invivoassessmentofclosantelovicidalactivityinfasciolahepaticaeggs
bdutipo_str	Repositorios
_version_	1764820541789700096

In vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs.

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