Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity

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VERSIÓN FINAL DE AUTORES ACEPTADA PARA PUBLICACIÓN (PRE-PRINT). In this review we discuss how sex steroids and prolactin affect regulation and responsiveness of B and T cells. Sex hormones exert profound effects on several physiological processes of nonreproductive tissues. In the immune system, sev...

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Autores principales: Recalde, Gabriela, Moreno-Sosa, Tamara, Yudica, Florencia, Quintero, Cristian, Sanchez, Belén, Jahn, Graciela, Kalergis, Alexis, Mackern- Oberti, Juan Pablo
Formato: Artículo Científico
Lenguaje:Inglés
Publicado: 2020
Materias:
Autoimmunity
Estrogen
Progesterone
Prolactin
T Cells
B Cells
Acceso en línea:http://repositorio.umaza.edu.ar//handle/00261/1535
Aporte de:
UMAZA Digital (Universidad MAZA - Mendoza) de Universidad Juan Agustín MAZA
id I56-R16200261-1535
record_format dspace
institution Universidad Juan Agustín MAZA
institution_str I-56
repository_str R-162
collection UMAZA Digital (Universidad MAZA - Mendoza)
language Inglés
orig_language_str_mv eng
topic Autoimmunity
Estrogen
Progesterone
Prolactin
T Cells
B Cells
spellingShingle Autoimmunity
Estrogen
Progesterone
Prolactin
T Cells
B Cells
Recalde, Gabriela
Moreno-Sosa, Tamara
Yudica, Florencia
Quintero, Cristian
Sanchez, Belén
Jahn, Graciela
Kalergis, Alexis
Mackern- Oberti, Juan Pablo
Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity
description VERSIÓN FINAL DE AUTORES ACEPTADA PARA PUBLICACIÓN (PRE-PRINT). In this review we discuss how sex steroids and prolactin affect regulation and responsiveness of B and T cells. Sex hormones exert profound effects on several physiological processes of nonreproductive tissues. In the immune system, several studies with experimental models for SLE have shown a noticeable pro-inflammatory role for ERα, contributing to disease development reflected in proteinuria and renal pathology. On the other hand, ERβ appears to have an antiinflammatory and immunosuppressive effect. Estrogen/ERα signaling induced an increase of Th17 cells in lymph nodes as well as the expression of its correspondent chemokine receptor CCR6 during collagen induced arthritis acute phase. High levels of anti- DNA antibodies and increased mortality was observed when given high E and prolactin doses to NZB/NZW mice, as compared with mice receiving low E and prolactin doses, or high E and low prolactin doses. Intracellular progesterone receptors have been detected in TCD4+ cells but in contrast as observed with ERs, it suppresses T cell dependent responses. Progestagen administration on female NZB/NZW mice decreased anti DNA IgG, improved survival, decreased glomerulonephritis and proteinuria.
format Artículo Científico
author Recalde, Gabriela
Moreno-Sosa, Tamara
Yudica, Florencia
Quintero, Cristian
Sanchez, Belén
Jahn, Graciela
Kalergis, Alexis
Mackern- Oberti, Juan Pablo
author_facet Recalde, Gabriela
Moreno-Sosa, Tamara
Yudica, Florencia
Quintero, Cristian
Sanchez, Belén
Jahn, Graciela
Kalergis, Alexis
Mackern- Oberti, Juan Pablo
author_sort Recalde, Gabriela
title Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity
title_short Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity
title_full Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity
title_fullStr Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity
title_full_unstemmed Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity
title_sort contribution of sex steroids and prolactin to the modulation of t and b cells during autoimmunity
publishDate 2020
url http://repositorio.umaza.edu.ar//handle/00261/1535
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