Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity
In this review we discuss how sex steroids and prolactin affect regulation and responsiveness of B and T cells. Sex hormones exert profound effects on several physiological processes of nonreproductive tissues. In the immune system, several studies with experimental models for SLE have shown a notic...
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Acceso en línea: | http://repositorio.umaza.edu.ar//handle/00261/1535 |
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I56-R162-00261-15352023-04-12T12:03:16Z Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity Recalde, Gabriela Moreno-Sosa, Tamara Yudica, Florencia Quintero, Cristian Sanchez, Belén Jahn, Graciela Kalergis, Alexis Mackern- Oberti, Juan Pablo Autoimmunity Estrogen Progesterone Prolactin T Cells B Cells In this review we discuss how sex steroids and prolactin affect regulation and responsiveness of B and T cells. Sex hormones exert profound effects on several physiological processes of nonreproductive tissues. In the immune system, several studies with experimental models for SLE have shown a noticeable pro-inflammatory role for ERα, contributing to disease development reflected in proteinuria and renal pathology. On the other hand, ERβ appears to have an antiinflammatory and immunosuppressive effect. Estrogen/ERα signaling induced an increase of Th17 cells in lymph nodes as well as the expression of its correspondent chemokine receptor CCR6 during collagen induced arthritis acute phase. High levels of anti- DNA antibodies and increased mortality was observed when given high E and prolactin doses to NZB/NZW mice, as compared with mice receiving low E and prolactin doses, or high E and low prolactin doses. Intracellular progesterone receptors have been detected in TCD4+ cells but in contrast as observed with ERs, it suppresses T cell dependent responses. Progestagen administration on female NZB/NZW mice decreased anti DNA IgG, improved survival, decreased glomerulonephritis and proteinuria. 2020-07-03T11:22:33Z 2020-07-03T11:22:33Z 2017-12-16 Artículo Científico Recalde, G., Moreno-Sosa, T., Yudica, F., Quintero,C., Sanchez, B., Jahn, G.,Kalergis, A., Mackern-Oberti, J.P. (2017) Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity. Autoimmunity Reviews http://repositorio.umaza.edu.ar//handle/00261/1535 eng application/pdf |
institution |
Universidad Juan Agustín MAZA |
institution_str |
I-56 |
repository_str |
R-162 |
collection |
UMAZA Digital (Universidad MAZA - Mendoza) |
language |
Inglés |
orig_language_str_mv |
eng |
topic |
Autoimmunity Estrogen Progesterone Prolactin T Cells B Cells |
spellingShingle |
Autoimmunity Estrogen Progesterone Prolactin T Cells B Cells Recalde, Gabriela Moreno-Sosa, Tamara Yudica, Florencia Quintero, Cristian Sanchez, Belén Jahn, Graciela Kalergis, Alexis Mackern- Oberti, Juan Pablo Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity |
topic_facet |
Autoimmunity Estrogen Progesterone Prolactin T Cells B Cells |
description |
In this review we discuss how sex steroids and prolactin affect regulation and responsiveness of B and T cells. Sex hormones exert profound effects on several physiological processes of nonreproductive tissues. In the immune system, several studies with experimental models for SLE have shown a noticeable pro-inflammatory role for ERα, contributing to disease development reflected in proteinuria and renal pathology. On the other hand, ERβ appears to have an antiinflammatory and immunosuppressive effect. Estrogen/ERα signaling induced an increase of Th17 cells in lymph nodes as well as the expression of its correspondent chemokine receptor CCR6 during collagen induced arthritis acute phase. High levels of anti- DNA antibodies and increased mortality was observed when given high E and prolactin doses to NZB/NZW mice, as compared with mice receiving low E and prolactin doses, or high E and low prolactin doses. Intracellular progesterone receptors have been detected in TCD4+ cells but in contrast as
observed with ERs, it suppresses T cell dependent responses. Progestagen administration on female NZB/NZW mice decreased anti DNA IgG, improved survival, decreased glomerulonephritis and proteinuria. |
format |
Artículo Científico |
author |
Recalde, Gabriela Moreno-Sosa, Tamara Yudica, Florencia Quintero, Cristian Sanchez, Belén Jahn, Graciela Kalergis, Alexis Mackern- Oberti, Juan Pablo |
author_facet |
Recalde, Gabriela Moreno-Sosa, Tamara Yudica, Florencia Quintero, Cristian Sanchez, Belén Jahn, Graciela Kalergis, Alexis Mackern- Oberti, Juan Pablo |
author_sort |
Recalde, Gabriela |
title |
Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity |
title_short |
Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity |
title_full |
Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity |
title_fullStr |
Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity |
title_full_unstemmed |
Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity |
title_sort |
contribution of sex steroids and prolactin to the modulation of t and b cells during autoimmunity |
publishDate |
2020 |
url |
http://repositorio.umaza.edu.ar//handle/00261/1535 |
work_keys_str_mv |
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