Human papillomavirus genotypes in women with cervical cytological abnormalities from an area with high incidence of cervical cancer

It has been well demonstrated the relationship between the infection with high-risk human papillomavirus (HPVs) genotypes and cervical cancer. In Northeastern Argentina a high incidence of this pathology has been described and therefore a high prevalence of HPV infection is expected. In order to ide...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Deluca, Gerardo Daniel, Lucero, Raúl Horacio, Martin de Civetta, María Teresa, Vicente, Lilian, Zibelman de Gorodner, Ofelia Lidia, Schelover, Eduardo, Alonso, José Mario
Formato: Artículo
Lenguaje:Inglés
Publicado: Instituto de Medicina Tropical de São Paulo 2022
Materias:
HPV
Cervical cancer
Papillomavirus
PCR-RFLP
Virus papiloma humano
Cáncer cervical
Acceso en línea:http://repositorio.unne.edu.ar/handle/123456789/48857
Aporte de:
RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) de Universidad Nacional del Nordeste
id I48-R184-123456789-48857
record_format dspace
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-184
collection RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
language Inglés
topic HPV
Cervical cancer
Papillomavirus
PCR-RFLP
Virus papiloma humano
Cáncer cervical
spellingShingle HPV
Cervical cancer
Papillomavirus
PCR-RFLP
Virus papiloma humano
Cáncer cervical
Deluca, Gerardo Daniel
Lucero, Raúl Horacio
Martin de Civetta, María Teresa
Vicente, Lilian
Zibelman de Gorodner, Ofelia Lidia
Schelover, Eduardo
Alonso, José Mario
Human papillomavirus genotypes in women with cervical cytological abnormalities from an area with high incidence of cervical cancer
topic_facet HPV
Cervical cancer
Papillomavirus
PCR-RFLP
Virus papiloma humano
Cáncer cervical
description It has been well demonstrated the relationship between the infection with high-risk human papillomavirus (HPVs) genotypes and cervical cancer. In Northeastern Argentina a high incidence of this pathology has been described and therefore a high prevalence of HPV infection is expected. In order to identify HPV genotypes associated with malignant and pre-malignant cervical lesions present in the area, 53 ecto-endo cervical cell specimens obtained from women with cytohistological alterations were studied by a PCR-RFLP technique. Out of 53 patients, 34 (64.2%) were positive for HPV infection, being HPV-16 (32.3%) the most frequently found genotype, followed by HPV-58 (14.7%), -6, -18 and –45 (5.9%), -33, -52, -53, -54, -56, -66, -MM4 and –LVX100 (2.9%). Also 5 cases of infection caused by multiple genotypes were found, which corresponded to 14.7% of the positive cases. Results indicate that besides HPV-16 and –18, the most prevalent high-risk HPV genotypes worldwide, others like –45 and –58 as well as co-infection cases are frequent between women of Northeastern Argentina, and a particular attention should be paid to this circumstance because it could be an epidemiological feature of regional importance and a useful information for a future vaccination program.
format Artículo
author Deluca, Gerardo Daniel
Lucero, Raúl Horacio
Martin de Civetta, María Teresa
Vicente, Lilian
Zibelman de Gorodner, Ofelia Lidia
Schelover, Eduardo
Alonso, José Mario
author_facet Deluca, Gerardo Daniel
Lucero, Raúl Horacio
Martin de Civetta, María Teresa
Vicente, Lilian
Zibelman de Gorodner, Ofelia Lidia
Schelover, Eduardo
Alonso, José Mario
author_sort Deluca, Gerardo Daniel
title Human papillomavirus genotypes in women with cervical cytological abnormalities from an area with high incidence of cervical cancer
title_short Human papillomavirus genotypes in women with cervical cytological abnormalities from an area with high incidence of cervical cancer
title_full Human papillomavirus genotypes in women with cervical cytological abnormalities from an area with high incidence of cervical cancer
title_fullStr Human papillomavirus genotypes in women with cervical cytological abnormalities from an area with high incidence of cervical cancer
title_full_unstemmed Human papillomavirus genotypes in women with cervical cytological abnormalities from an area with high incidence of cervical cancer
title_sort human papillomavirus genotypes in women with cervical cytological abnormalities from an area with high incidence of cervical cancer
publisher Instituto de Medicina Tropical de São Paulo
publishDate 2022
url http://repositorio.unne.edu.ar/handle/123456789/48857
work_keys_str_mv AT delucagerardodaniel humanpapillomavirusgenotypesinwomenwithcervicalcytologicalabnormalitiesfromanareawithhighincidenceofcervicalcancer
AT luceroraulhoracio humanpapillomavirusgenotypesinwomenwithcervicalcytologicalabnormalitiesfromanareawithhighincidenceofcervicalcancer
AT martindecivettamariateresa humanpapillomavirusgenotypesinwomenwithcervicalcytologicalabnormalitiesfromanareawithhighincidenceofcervicalcancer
AT vicentelilian humanpapillomavirusgenotypesinwomenwithcervicalcytologicalabnormalitiesfromanareawithhighincidenceofcervicalcancer
AT zibelmandegorodnerofelialidia humanpapillomavirusgenotypesinwomenwithcervicalcytologicalabnormalitiesfromanareawithhighincidenceofcervicalcancer
AT schelovereduardo humanpapillomavirusgenotypesinwomenwithcervicalcytologicalabnormalitiesfromanareawithhighincidenceofcervicalcancer
AT alonsojosemario humanpapillomavirusgenotypesinwomenwithcervicalcytologicalabnormalitiesfromanareawithhighincidenceofcervicalcancer
AT delucagerardodaniel genotiposdeviruspapilomahumanoenmujeresconalteracionescitologicascervicalesdeunareaconaltaincidenciadecancercervical
AT luceroraulhoracio genotiposdeviruspapilomahumanoenmujeresconalteracionescitologicascervicalesdeunareaconaltaincidenciadecancercervical
AT martindecivettamariateresa genotiposdeviruspapilomahumanoenmujeresconalteracionescitologicascervicalesdeunareaconaltaincidenciadecancercervical
AT vicentelilian genotiposdeviruspapilomahumanoenmujeresconalteracionescitologicascervicalesdeunareaconaltaincidenciadecancercervical
AT zibelmandegorodnerofelialidia genotiposdeviruspapilomahumanoenmujeresconalteracionescitologicascervicalesdeunareaconaltaincidenciadecancercervical
AT schelovereduardo genotiposdeviruspapilomahumanoenmujeresconalteracionescitologicascervicalesdeunareaconaltaincidenciadecancercervical
AT alonsojosemario genotiposdeviruspapilomahumanoenmujeresconalteracionescitologicascervicalesdeunareaconaltaincidenciadecancercervical
bdutipo_str Repositorios
_version_ 1764820539732393987

Ejemplares similares