Jatropha cake (jatropha curcas) : hepatotoxic implications

Jatropha has been highlighted as an oleaginous potential for the production of biofuel. The cake, produced by oil extraction, could be used in animal feed. However, some varieties of jatropha are toxic by limiting their incorporation into animal diets. The objective of this study was to evaluate t...

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Autores principales: Honorato, Claucia Aparecida, Da Silva, César José, Flores Quintana, Carolina Isabel, Mendonça, Simone, Nascimento, Camila Aparecida, Marcondes, Vanessa Menegatti, Parente, Bruna Oliveira, Machado de Araújo, Miguel Augusto
Formato: Artículo
Lenguaje:Inglés
Publicado: University of São Paulo. School of Veterinary Medicine and Animal Science 2022
Materias:
Toxic
The hepatotoxicity
Animal feed
Tóxico
À hepatotoxicidade
Alimentação animal
Acceso en línea:http://repositorio.unne.edu.ar/handle/123456789/48648
Aporte de:
RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) de Universidad Nacional del Nordeste
id I48-R184-123456789-48648
record_format dspace
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-184
collection RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
language Inglés
topic Toxic
The hepatotoxicity
Animal feed
Tóxico
À hepatotoxicidade
Alimentação animal
spellingShingle Toxic
The hepatotoxicity
Animal feed
Tóxico
À hepatotoxicidade
Alimentação animal
Honorato, Claucia Aparecida
Da Silva, César José
Flores Quintana, Carolina Isabel
Mendonça, Simone
Nascimento, Camila Aparecida
Marcondes, Vanessa Menegatti
Parente, Bruna Oliveira
Machado de Araújo, Miguel Augusto
Jatropha cake (jatropha curcas) : hepatotoxic implications
topic_facet Toxic
The hepatotoxicity
Animal feed
Tóxico
À hepatotoxicidade
Alimentação animal
description Jatropha has been highlighted as an oleaginous potential for the production of biofuel. The cake, produced by oil extraction, could be used in animal feed. However, some varieties of jatropha are toxic by limiting their incorporation into animal diets. The objective of this study was to evaluate the hepatotoxicity of diets added with jatropha cake – JC (Jatropha curcas) in rats. Thirty-five (35) male Wistar adults rats (Rattus norvegicus) with initial weight of 352.1 ± 26.8 g were used. The animals were fed for 21 days with the diets: control, 10, 25, 40 and 50% JC. In the feeding with 50% JC the animals presented themselves prostrate and with piloerection. Development and survival decreased, since the inclusion of JC in diets increased. In rats submitted to 10 and 25% JC there was an increase of 17.52% in the hepatosomatic index in relation to the control group. Increase of JC in the rat diet promoted an increase in the activity of ALT and AST enzymes. Anatomic-histopathological evaluation demonstrated that, regardless of the levels tested, JC in rat diet causes hypertrophy of the hepatocytes, with a reduction in energy reserves. This study demonstrated that the use of JC resulted in decreased food intake, associated with weight loss due to the clinical pattern of toxicity, demonstrated by biochemical and histopathological changes in the liver. It was concluded that the inclusion of jatropha cake in rat feeding presents high hepatotoxic potential leading to lesions in the liver parenchyma.
format Artículo
author Honorato, Claucia Aparecida
Da Silva, César José
Flores Quintana, Carolina Isabel
Mendonça, Simone
Nascimento, Camila Aparecida
Marcondes, Vanessa Menegatti
Parente, Bruna Oliveira
Machado de Araújo, Miguel Augusto
author_facet Honorato, Claucia Aparecida
Da Silva, César José
Flores Quintana, Carolina Isabel
Mendonça, Simone
Nascimento, Camila Aparecida
Marcondes, Vanessa Menegatti
Parente, Bruna Oliveira
Machado de Araújo, Miguel Augusto
author_sort Honorato, Claucia Aparecida
title Jatropha cake (jatropha curcas) : hepatotoxic implications
title_short Jatropha cake (jatropha curcas) : hepatotoxic implications
title_full Jatropha cake (jatropha curcas) : hepatotoxic implications
title_fullStr Jatropha cake (jatropha curcas) : hepatotoxic implications
title_full_unstemmed Jatropha cake (jatropha curcas) : hepatotoxic implications
title_sort jatropha cake (jatropha curcas) : hepatotoxic implications
publisher University of São Paulo. School of Veterinary Medicine and Animal Science
publishDate 2022
url http://repositorio.unne.edu.ar/handle/123456789/48648
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